Newest studies

Long-term impact of disclosing amyloid PET results to individuals with subjective cognitive decline

38/100 ✓ Peer-reviewed Biomarkers Alzheimer s Research & Therapy

Key finding: Participants’ motivations for testing and long-term adaptation to the results were strongly shaped by cognitive concerns and personal experiences of dementia in relatives. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Medicaid Home and Community-Based Services Initiation and Acute Services Use

46/100 ✓ Peer-reviewed Health systems and care delivery JAMA Health Forum

Key finding: In a sample of 1218 new HCBS users (75% female, 77% Black; mean [SD] age, 70.5 [7.5] years), Medicaid HCBS initiation was associated with a decrease in probability of ED use (-2.70 percentage points; 95% CI, -4.18 to -1.22 percentage points) and a decrease in probability of inpatient discharge (-2.63 percentage points; 95% CI, -3.75 to -1.51 percentage points). +4 more findings

• Policy

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Delirium, long-term conditions, and incident dementia in older adults admitted to hospital for emergency care in Lothian, Scotland: a population-based cohort study

67/100 ✓ Peer-reviewed How common it is The lancet. Healthy longevity

Key finding: Of 23 558 people without pre-existing dementia, 4135 (17·6%) had an admission with delirium. +4 more findings

• Risk Factors
• Care Services

Full summary, score breakdown and related studies → Original source

Dementia Burden and Modifiable Risk Factors in Type 2 Diabetes: Population Based, Prospective Cohort Study

39/100 ✓ Peer-reviewed Risk factors Diabetes Obesity and Metabolism

Key finding: T2D was associated with a higher risk and earlier onset of dementia, especially in cases with T2D diagnosed at ages 30-54 years. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

The role of mitochondria in Alzheimer's disease

29/100 ✓ Peer-reviewed Risk genes beyond APOE Zenodo (CERN European Organization for Nuclear Research)

Key finding: The 18 kDa translocator protein (TSPO), a neuroinflammation protein expressed by glial and endothelial cells.Aβ40 and 42 soluble and insoluble will also be quantified, they are involved in the physiology of the human body and in Alzheimer’s disease forAβ42.Aβ total and Tau will be analyzed. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

The role of mitochondria in Alzheimer's disease

41/100 ✓ Peer-reviewed Risk genes beyond APOE Zenodo (CERN European Organization for Nuclear Research)

Key finding: The 18 kDa translocator protein (TSPO), a neuroinflammation protein expressed by glial and endothelial cells.Aβ40 and 42 soluble and insoluble will also be quantified, they are involved in the physiology of the human body and in Alzheimer’s disease forAβ42.Aβ total and Tau will be analyzed. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Locus coeruleus TDP-43 pathology in a community-based cohort: Clinical and pathological correlates

46/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Neuropathology & Experimental Neurology

Key finding: In terms of clinical-pathological correlations, LC pTDP-43 pathology was associated with depressive symptoms but not with global cognition or with other BPSDs. +1 more finding

• Brain Biology

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A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms

42/100 ✓ Peer-reviewed Brain tissue and pathology PLoS Biology

Key finding: Together, these findings reveal a molecularly guided strategy to directly impact TDP-43 activity by decreasing its misfolding and aggregation, highlighting approaches to prevent TDP-43 dysfunction and mitigate toxicity under pathological conditions.

• Brain Biology

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Blood level of β-amyloid, Tau, and p-Tau in mild cognitive impairment and Alzheimer disease: A follow up study

36/100 ✓ Peer-reviewed Mild cognitive impairment The Indian Journal of Medical Research

Key finding: Comparison of proteins between the three groups revealed significantly lower Aβ1-42, higher Tau and pTau protein expression in serum of patients with Alzheimer disease as compared to patients with mild cognitive impairment and controls. +3 more findings

• Early Stage

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Mapping Caregiver Needs to AI Chatbot Design: Strengths and Gaps in Mental Health Support for Alzheimer's and Dementia Caregivers

41/100 ✓ Peer-reviewed Caregiving ACM Transactions on Computing for Healthcare

Key finding: Family caregivers of individuals with Alzheimer’s Disease and Related Dementia (AD/ADRD) face significant emotional and logistical challenges that place them at heightened risk for stress, anxiety, and depression. +1 more finding

• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

Single-Cell Transcriptomic Identification of SYK Kinase as a Therapeutic Target in Disease-Associated Microglia for Alzheimer's Disease Treatment

28/100 ✓ Peer-reviewed Risk genes beyond APOE Zenodo (CERN European Organization for Nuclear Research)

Key finding: ChEMBL screening across 8 microglial DAM-relevant targets identified 6,230 NOVEL_ALL inhibitor candidates. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Single-Cell Transcriptomic Identification of SYK Kinase as a Therapeutic Target in Disease-Associated Microglia for Alzheimer's Disease Treatment

41/100 ✓ Peer-reviewed Risk genes beyond APOE Zenodo (CERN European Organization for Nuclear Research)

Key finding: ChEMBL screening across 8 microglial DAM-relevant targets identified 6,230 NOVEL_ALL inhibitor candidates. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Sensitivity comparison of longitudinal cognitive function indicators of Alzheimer’s disease after mild cognitive impairment: a prospective cohort study

53/100 ✓ Peer-reviewed Mild cognitive impairment Scientific Reports

Key finding: Calibration curves demonstrated good agreement between predicted and observed survival.

• Early Stage
• Genetics

Full summary, score breakdown and related studies → Original source

Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan

48/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Acta neuropathologica

Key finding: Individuals with Down syndrome (DS) have an increased risk of developing Alzheimer disease (AD), with nearly all individuals exhibiting AD neuropathology, including amyloid beta (Aβ) plaques and neurofibrillary tangles (NFT), by age 40 years. +4 more findings

• Brain Biology
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Comprehensive single-cell transcriptomic atlas of microglia in Alzheimer's disease mouse models

48/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: Here, we constructed a comprehensive Mouse Microglia Atlas (MoMicA) to resolve conserved subtypes, delineate dynamic trajectories, and identify key regulators associated with AD pathology.

• Brain Biology

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How does Australian primary care face dementia? Identifying current practice and barriers in dementia diagnosis and management in Australian primary care – a qualitative interview study

39/100 ✓ Peer-reviewed Getting a diagnosis BMC Family Practice

Key finding: Four themes described current primary care practitioner practices in dementia diagnosis and management (1) Family concern triggers dementia investigation (2) GPs delay conversations about dementia (3) Completing routine cognitive assessments in the 75+ health assessment, and (4) Variability in post-diagnostic care. +3 more findings

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Redirection Hypothesis Alzheimers

28/100 ✓ Peer-reviewed Biomarkers Zenodo (CERN European Organization for Nuclear Research)

Key finding: The most successful amyloid-targeting treatments achieve modest plaque reduction with marginal clinical benefit and significant adverse effects.

Full summary, score breakdown and related studies → Original source

Redirection Hypothesis Alzheimers

41/100 ✓ Peer-reviewed Biomarkers Zenodo (CERN European Organization for Nuclear Research)

Key finding: The most successful amyloid-targeting treatments achieve modest plaque reduction with marginal clinical benefit and significant adverse effects.

Full summary, score breakdown and related studies → Original source

Real-world implementation of lecanemab and donanemab in an Italian memory center: a 1-year experience

66/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: In donanemab-treated patients, mildly symptomatic ARIA-E occurred in 10% (2/20) and asymptomatic ARIA-H in 15% (3/20). +4 more findings

• Treatments
• Biomarkers

Full summary, score breakdown and related studies → Original source

Frequent in dementia, deadliest without it: delirium and mortality in hospitalised older adults

65/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: Among 2556 patients (mean age 79 ± 9 years; 56% women), delirium occurred in 957 (37%). +4 more findings

• Care Services

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The Benson Complex Figure Test for the Differential Diagnosis of Dementias

44/100 ✓ Peer-reviewed Cognitive tests and assessment NeuroSci

Key finding: Multinomial logistic regression, adjusted for age, sex, and education, revealed distinct BCFT profiles across dementia subtypes. +3 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Association between zinc deficiency and adverse outcomes in patients with dementia: a matched cohort study

58/100 ✓ Peer-reviewed How common it is Frontiers in Nutrition

Key finding: In this observational study, zinc deficiency was associated with increased 1-year mortality and infection-related complications in patients with dementia, with evidence of a dose–response relationship. +4 more findings

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Interactive effects of telomere length and genetic variants on Alzheimer disease risk across multiple ancestral populations

42/100 ✓ Peer-reviewed Genetics Alzheimer s Research & Therapy

Key finding: AD risk was associated with shorter TL (β = -0.48, P < 2 × 10–16). +4 more findings

• Genetics

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Effect of Glucagon-Like-Peptide-1 Receptor Agonists (GLP-1 RA) on Neuropsychiatric Outcomes: A Systematic Review and Meta-Analysis

79/100 ✓ Peer-reviewed Drug development Clinical therapeutics

Key finding: From 10,037 records, 82 studies were included. +4 more findings

• Treatments
• Risk Factors

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Association of the Big Five personality traits with cognitive decline: a 24-week multidomain intervention study

56/100 ✓ Peer-reviewed Prevention trials Frontiers in Psychiatry

Key finding: Among the five personality domains, only extraversion was significantly associated with reduced odds of cognitive decline within the intervention group over 24 weeks (fully adjusted model: OR = 0.35; 95% CI: 0.15-0.82). +1 more finding

• Clinical Trials

Full summary, score breakdown and related studies → Original source