Newest studies

Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients

51/100 ✓ Peer-reviewed Genetics JAMA Network Open

Key finding: Among 203 enrolled patients, 186 (mean [SD] age, 68.7 [5.2] years; 119 males [64.0%]) were randomized (137 to the CN-105 group, 49 to the placebo group) and underwent surgery. +4 more findings

• Clinical Trials
• Genetics

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The role of spirituality among nursing home staff caring for residents with advanced dementia: a qualitative descriptive study

35/100 ✓ Peer-reviewed End-of-life care International Journal of Palliative Nursing

Key finding: Four themes described how staff perceived spirituality to influence their work to comfort, guide, protect and make meaning. +1 more finding

• Caregiving
• Care Services

Full summary, score breakdown and related studies → Original source

Cinnamon Bud Extract Is a Source of Biomolecules Active against the Aggregation and Condensation of Alzheimer′s-Associated Tau Protein

38/100 ✓ Peer-reviewed Disease mechanisms Journal of Agricultural and Food Chemistry

Key finding: In vitro results show that BCHE and cinnamaldehyde inhibit tau aggregate maturation, promoting the formation of nonfibrillar, off-pathway species and modulating condensate formation. +1 more finding

• Brain Biology

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Cost-utility analysis of cerebrospinal fluid versus blood biomarkers for early detection of Alzheimer’s disease and mild cognitive impairment in Thailand: a modeling study

36/100 ✓ Peer-reviewed Mild cognitive impairment BMC Health Services Research

Key finding: Compared with no testing, the CSF strategy yielded 0.011 additional life-years and 0.019 additional QALYs for an extra cost of THB2,589 (USD71), resulting in an ICER of THB132,961 (USD3,632) per QALY. +1 more finding

• Biomarkers
• Early Stage
• Policy

Full summary, score breakdown and related studies → Original source

Longitudinal Evaluation of 18 F-MK-6240 Along the Alzheimer Disease Continuum

54/100 ✓ Peer-reviewed Brain scans and imaging Journal of Nuclear Medicine

Key finding: Baseline 18F-MK-6240 PET showed a minimal signal in CU participants, localized signal to the medial temporal lobe in participants with MCI, and a signal spanning the inferolateral temporal lobe and extending posteriorly along the ventral cortex in participants with AD. +4 more findings

Full summary, score breakdown and related studies → Original source

Mapping spatial hotspots and location specific associated factor of diarrhea-wasting multimorbidity among children aged 6–24 months in East Africa: a geographically weighted regression analysis

40/100 ✓ Peer-reviewed Risk factors Scientific Reports

Key finding: DWM prevalence averaged 3% (range: 1–6%) with significant spatial clustering (Moran’s I = 0.145, Z = 38.07, p < 0.001); hotspots spanned Ethiopia, Uganda, Rwanda, Burundi, Tanzania, Malawi, Mozambique, and Madagascar. +1 more finding

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Geographic Variation in ADRD Prevalence and Mortality and Their Association with Social Vulnerability across US Counties: A Spatial Epidemiological Analysis Using NORC and CDC SVI Data

38/100 ✓ Peer-reviewed Risk factors Dementia and Geriatric Cognitive Disorders Extra

Key finding: Counties had a mean prevalence of 65.3 per 1,000 (SD 15.5) for highly likely ADRD and 123.5 per 1,000 (SD 27.0) for all determinations. +4 more findings

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Risk factors for early-onset and late-onset dementia: a prospective cohort study

65/100 ✓ Peer-reviewed Prevention and risk The lancet. Healthy longevity

Key finding: Female participants had a lower hazard of early-onset dementia compared with males (HR 0·70 [95% CI 0·61-0·80]). +3 more findings

• Risk Factors
• Prevention

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Predicting the age of Alzheimer’s symptom onset from a blood test: evaluating a prognostic claim

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: The clock claims are unsupported. +2 more findings

• Biomarkers

Scored 42 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease

85/100 ✓ Peer-reviewed Clinical trials Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Mean percentage change in plasma p-tau217 in the SAMe group was an increase of 53.22 (standard deviation [SD] 159.19) compared to 25.34 (SD 94.83) in the placebo group (standardized mean difference 37.58, 95% confidence interval -32.61, 107.76; p = 0.288). +3 more findings

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Review of Donanemab and Lecanemab in Mild Dementia Stage of Alzheimer's Disease: Progress and Challenges

48/100 ✓ Peer-reviewed Treatments The Senior care pharmacist

Key finding: Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline and functional impairment, primarily driven by the accumulation of amyloid-beta (Aβ) plaques and tau tangles. +4 more findings

• Treatments
• Side Effects
• Brain Biology

Full summary, score breakdown and related studies → Original source

Associations between sleep disturbance and cerebrospinal fluid Aβ, and shared proteomic signatures in Alzheimer's disease

75/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Baseline sleep disturbance was associated with a faster rate of longitudinal CSF Aβ42 decline. +3 more findings

• Biomarkers
• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Midlife sleep characteristics and Alzheimer's disease biomarkers 20 years later

59/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: After multivariable adjustment, longer sleep duration was associated with lower Aβ42/40, poor sleep quality with higher NfL, daytime sleepiness with both lower Aβ42/40 and higher NfL, and insomnia symptoms with higher SPARE-AD. +2 more findings

• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source

Analytical and clinical validation of the Lumipulse G plasma p-tau217 assay for clinical implementation

48/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The assay demonstrated strong analytical performance, with repeatability and intermediate precision (%CV < 7%) and an LLoQ of 0.12 pg/mL. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Combining p-tau217 and digital cognitive testing to predict cognitive decline

73/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Adding MDLC to p-tau217 significantly explained longitudinal cognitive trajectory beyond p-tau217 alone. +4 more findings

• Biomarkers
• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Microglial reactivity predicts hippocampal, but not global, atrophy in cerebral small vessel disease

38/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia

Key finding: Our data suggests that microglial reactivity may play a role in hippocampal atrophy; potentially contributing to the increasingly recognized interaction between vascular and neurodegenerative pathology. +2 more findings

• Other Dementias
• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

2026 Alzheimer's disease facts and figures

47/100 ✓ Peer-reviewed End-of-life care Alzheimer s & Dementia

Key finding: Between 2000 and 2024, deaths from stroke, heart disease, and HIV decreased, whereas reported deaths from AD increased 134%.

• Caregiving
• Policy

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Barriers and facilitators to home-based end-of-life care for people with dementia: A meta-ethnographic study

36/100 ✓ Peer-reviewed End-of-life care International Journal of Nursing Studies

Key finding: Six core themes were identified through the synthesis of data from 17 studies. +4 more findings

• End-of-Life Care

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Ultra‐processed food intake, cognitive function, and dementia risk: A cross‐sectional study of middle‐aged and older Australian adults

40/100 ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: Each 10% increase in UPF intake was associated with lower attention scores (-0.05 points) and higher dementia risk (+0.24 points), independent of Mediterranean diet adherence. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Weight loss and metabolic improvements dominate the microbiome response in the MIND diet intervention: a randomized controlled trial

54/100 ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: Both groups exhibited significant, transient microbiome remodeling at Year 1 (the period of most active weight loss). +4 more findings

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Florzolotau (18F) retention is linked to neuropsychological performance in tauopathy

37/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s & Dementia

Key finding: In the AD continuum group, all cognitive test performances significantly correlated with tracer uptake, particularly in the left cortical areas. +3 more findings

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Immune–proteo–metabolomic changes link to Aβ and tau pathology in Alzheimer disease

45/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer s & Dementia

Key finding: Thirteen differentially expressed CSF proteins in A+T+ individuals correlated positively with tryptophan metabolites and pyroglutamate, and negatively with regulatory T cells, isobutyrate, and dendritic cells. +3 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

The Influence of Lifestyle on Cognitive Function and Quality of Life in People with Dementia

34/100 ✓ Peer-reviewed Cognitive tests and assessment Neuropsychiatric Disease and Treatment

Key finding: Univariate analysis revealed that smoking, moderate aerobic exercise and smartphone use were positively correlated with MMSE score. +4 more findings

• Lifestyle

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The role of verbal episodic memory in progression to mild cognitive impairment: The influence of serial position effects

40/100 ✓ Peer-reviewed Mild cognitive impairment International Psychogeriatrics

Key finding: SCD participants were older, had fewer years of education, more depressive symptoms, and more subjective cognitive complaints than CU participants. +3 more findings

• Early Stage

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Mild cognitive impairment‐to‐Alzheimer's dementia progression risk: the contribution of the Interceptor project

46/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: Dementia developed in 104 individuals (29.6%), including 85 (22.4%) who met core clinical criteria for probable and possible Alzheimer's disease dementia. +2 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source