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Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease
Hamelin L, Lagarde J, Dorothée G, Potier MC, Corlier F, Kuhnast B, Caillé F, Dubois B et al.. Brain : a journal of neurology, 2018-06-01
Topic: Amyloid, tau and blood-test diagnosis
Although brain neuroinflammation may play an instrumental role in the pathophysiology of Alzheimer's disease, its actual impact on disease progression remains controversial, being reported as either detrimental or protective. This work aimed at investigating the temporal relationship between microglial activation and clinical progression of Alzheimer's disease. First, in a large cohort of patients with Alzheimer's disease we analysed the predictive value of microglial activation assessed by 18F-DPA-714 PET imaging on functional, cognitive and MRI biomarkers outcomes after a 2-year follow-up.
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APA 7th
Hamelin, L., Lagarde, J., Dorothée, G., Potier, M. C., Corlier, F., Kuhnast, B., et al. (2018). Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease. Brain : a journal of neurology. https://doi.org/10.1093/brain/awy079
Vancouver
Hamelin L, Lagarde J, Dorothée G, Potier MC, Corlier F, Kuhnast B, et al. Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease. Brain : a journal of neurology. 2018. doi:10.1093/brain/awy079. PMID: 29608645.
BibTeX
@article{hamelin2018-29608645,
author = {Hamelin, L. and Lagarde, J. and Dorothée, G. and Potier, M. C. and Corlier, F. and Kuhnast, B. and Caillé, F. and Dubois, B. and others},
title = {{Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease}},
journal = {Brain : a journal of neurology},
year = {2018},
doi = {10.1093/brain/awy079},
pmid = {29608645},
url = {https://doi.org/10.1093/brain/awy079}
}
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Key findings
- This work aimed at investigating the temporal relationship between microglial activation and clinical progression of Alzheimer's disease.
- First, in a large cohort of patients with Alzheimer's disease we analysed the predictive value of microglial activation assessed by 18F-DPA-714 PET imaging on functional, cognitive and MRI biomarkers outcomes after a 2-year follow-up.
- Second, we analysed the longitudinal progression of 18F-DPA-714 binding in patients with Alzheimer's disease by comparison with controls, and assessed its influence on clinical progression.
- At baseline, all participants underwent a clinical assessment, brain MRI, 11C-PiB, 18F-DPA-714 PET imaging and TSPO genotyping.
Why it matters
This longitudinal study used PET imaging to examine the relationship over time between microglial activation and clinical progression in people with Alzheimer's disease. It is an observational imaging study and does not test any treatment, so it says nothing about curing or preventing Alzheimer's disease.
Study details
- Study designlongitudinal study
- Participants33
- Effect size13.2%; 4.2%; 15.8%
- Evidence strengthModerate
How this study scored 68/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 33 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 177 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 17.7 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 3 / 6 | Cited 6.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 3 / 4 | Cited 69 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Marie Sarazin: h-index 59 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 17 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29608645) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 68 / 100 | — |
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