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Pharmacogenetic studies in Alzheimer disease
T Zúñiga Santamaría, P Yescas Gómez, I Fricke Galindo, M González González, A Ortega Vázquez, M López López. Neurologia, 2018-06-10
Topic: Genetics and APOE
Potential pharmacogenetic biomarkers for AD have been identified; however, it is still necessary to conduct further research into other populations and to identify new biomarkers. This information could assist in predicting patient response to these drugs and contribute to better treatment decision-making in a context as complex as aging.
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APA 7th
Santamaría, T. Z., Gómez, P. Y., Galindo, I. F., González, M. G., Vázquez, A. O., & López, M. L. (2022). Pharmacogenetic studies in Alzheimer disease. Neurologia. https://doi.org/10.1016/j.nrl.2018.03.025
Vancouver
Santamaría TZ, Gómez PY, Galindo IF, González MG, Vázquez AO, López ML. Pharmacogenetic studies in Alzheimer disease. Neurologia. 2022. doi:10.1016/j.nrl.2018.03.025. PMID: 29898857.
BibTeX
@article{santamaria2022-29898857,
author = {Santamaría, T Zúñiga and Gómez, P Yescas and Galindo, I Fricke and González, M González and Vázquez, A Ortega and López, M López},
title = {{Pharmacogenetic studies in Alzheimer disease}},
journal = {Neurologia},
year = {2022},
doi = {10.1016/j.nrl.2018.03.025},
pmid = {29898857},
url = {https://doi.org/10.1016/j.nrl.2018.03.025}
}
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Key findings
- Potential pharmacogenetic biomarkers for AD have been identified; however, it is still necessary to conduct further research into other populations and to identify new biomarkers.
- This information could assist in predicting patient response to these drugs and contribute to better treatment decision-making in a context as complex as aging.
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Study details
- Participants33
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 27 of the 56 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurologia) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 33 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29898857) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 27 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 27 of the 56 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
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