Newest studies

A typology of sub-clinical senescent cognitive disorder

36/100 ✓ Peer-reviewed Cognitive tests and assessment The British journal of psychiatry : the journal of mental science

Key finding: Subclinical cognitive impairment was found to not constitute a unitary phenomenon and heterogeneous subgroups could be differentiated. +1 more finding

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Hippocampal atrophy in recurrent major depression

40/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America

Key finding: Hippocampal volumes of subjects with a history of major depressive episodes but currently in remission and with no known medical comorbidity were compared to matched normal controls by using volumetric magnetic resonance images. +2 more findings

• Brain Scans

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Daily rhythm of serum melatonin in patients with dementia of the degenerate type

43/100 ✓ Peer-reviewed Clinical safety Brain research

Key finding: Our results suggest that the probability of absent melatonin rhythm is higher in demented patients compared with subjects without dementia. +1 more finding

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Accuracy of clinical criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome)

47/100 ✓ Peer-reviewed Clinical safety Neurology

Key finding: Information from each patient's first and last visits to the medical center supplying the case was presented sequentially to the rater, and the rater's diagnosis was compared with the neuropathologic diagnosis of each case. +1 more finding

• Diagnosis

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Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

45/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America

Key finding: Astrocytosis in spinal cord was associated with a marked increase in glial fibrillary acidic protein immunoreactivity in the G1H mice, but not in the N1029 mice. +2 more findings

• Brain Biology
• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

15-year longitudinal study of blood pressure and dementia

70/100 ✓ Peer-reviewed Risk factors Lancet (London, England)

Key finding: Previously increased blood pressure may increase the risk for dementia by inducing small-vessel disease and white-matter lesions. +4 more findings

• Risk Factors

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Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the central nervous system and in Alzheimer's disease

42/100 ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology

Key finding: VLDL-r is present on resting and activated microglia, particularly those associated with senile plaques (SPs).

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women

43/100 ✓ Peer-reviewed Genetics American journal of human genetics

Key finding: Late-onset Alzheimer disease (AD) is associated with the apolipoprotein E (APOE)-epsilon4 allele. +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Proof of Efficacy of the Ginkgo Biloba Special Extract EGb 761 in Outpatients Suffering from Mild to Moderate Primary Degenerative Dementia of the Alzheimer Type or Multi-infarct Dementia

52/100 ✓ Peer-reviewed Clinical trials Pharmacopsychiatry

Key finding: The frequency of therapy responders in the two treatment groups differed significantly in favor of EGb 761, with p < 0.005 in Fisher's Exact Test. +1 more finding

• Clinical Trials
• Treatments

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Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia

48/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: All patient groups had significantly smaller volumes of the hippocampus compared with the control group. +1 more finding

• Other Dementias
• Brain Scans

Full summary, score breakdown and related studies → Original source

Determinants of burden in an Italian sample of Alzheimer's patient caregivers

38/100 ✓ Peer-reviewed Caregiving Journal of cross-cultural gerontology

Key finding: Our study underlines that the imperatives of dementia and caregiving appear to be so significant that they have similar consequences in the Italian population as well as in other very different cultures.

• Caregiving

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Dementia and adult-onset unprovoked seizures

53/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: In the absence of other prior neurologic insult, both AD and other dementias increase the risk of generalized- and partial-onset unprovoked seizures. +1 more finding

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An audit of palliative care in dementia

36/100 ✓ Peer-reviewed End-of-life care European journal of cancer care

Key finding: Palliation of other symptoms were inadequate compared to current accepted practice.

• End-of-Life Care

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Localization and cell association of C1q in Alzheimer's disease brain

43/100 ✓ Peer-reviewed Inflammation and the immune system Experimental neurology

Key finding: C1q has also been found associated with most but not all amyloid deposits in brain. +3 more findings

• Brain Biology

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Minimum Data Set Plus (MDS+) scores compared with scores from five rating scales

46/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society

Key finding: Cross-sectional correlational study of criterion-related validity. +3 more findings

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Cognition-related EEG abnormalities in nondemented Down syndrome subjects

29/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Dementia (Basel, Switzerland)

Key finding: In the power spectrum of the resting EEG, we found a cognition-related increase in power at 4.5 and 8.8 Hz, indicative of alpha-slowing, as in AD patients. +1 more finding

• Down Syndrome

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Polyamines in frontal cortex of patients with Down syndrome and Alzheimer disease

37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience letters

Key finding: Our results support the idea that besides other neurotransmitter systems, endogenous polyamine levels are altered in dementing illnesses such as Alzheimer disease and Down syndrome.

• Down Syndrome

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Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study

53/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Apolipoprotein E type 4 allele (apoE epsilon4) is associated with Alzheimer's disease (AD) in the late-onset familial form and in sporadic cases, but the age-associated risk in a randomly sampled elderly population is not established. +4 more findings

• Genetics

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Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E

57/100 ✓ Peer-reviewed Risk factors The New England journal of medicine

Key finding: In late middle age, cognitively normal subjects who are homozygous for the epsilon 4 allele for apolipoprotein E have reduced glucose metabolism in the same regions of the brain as in patients with probable Alzheimer's disease. +2 more findings

• Genetics
• Early Stage
• Risk Factors

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Age and education correction of Mini-Mental State Examination for English and Spanish-speaking elderly

54/100 ✓ Peer-reviewed Disparities Neurology

Key finding: Previous research has shown that the Mini-Mental State Examination (MMS) is biased as a measure of cognitive impairment in minority and low-education patients. +2 more findings

• Diagnosis
• Health Equity

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Assessment of activities of daily living in dementia: development of the Bristol Activities of Daily Living Scale

40/100 ✓ Peer-reviewed Caregiving Age and ageing

Key finding: It has 'construct' validity as demonstrated by principal components analysis.

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Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study

53/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: The logistic regression model was significant with an accuracy of 89%, sensitivity of 76%, and specificity of 94%. +2 more findings

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Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City

43/100 ✓ Peer-reviewed Genetics American journal of human genetics

Key finding: Apolipoprotein-E epsilon 4 (APOE-epsilon 4) has been consistently associated with Alzheimer disease (AD) and may be responsible for an earlier age at onset. +3 more findings

• Genetics
• Health Equity

Full summary, score breakdown and related studies → Original source

Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos

33/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging

Key finding: In the Mos-transgenic brain we found increased levels of phosphorylation at one epitope on tau containing serines 199 and 202 (numbering according to human tau), a pattern similar but not identical to that found in Alzheimer's disease. +1 more finding

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Crosslinking of apolipoprotein E by products of lipid peroxidation

38/100 ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology

Key finding: These data suggest that HNE covalently crosslinks APOE in P19 neuroglial cultures to form a 50 kDa protein, and that similar modifications of APOE appear to occur in vivo.

• Genetics

Full summary, score breakdown and related studies → Original source