Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,376–11,400 of 27,380 studies, newest first · page 456 of 1096.
July 2020 25
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2020-07-29
Artificial Intelligence in Health Care: Bibliometric Analysis
60/100 ✓ Peer-reviewed Digital health tools Journal of medical Internet research
Key finding: This analysis provides a comprehensive overview of the AI-related research conducted in the field of health care, which helps researchers, policy makers, and practitioners better understand the development of health care-related AI research and possible practice implications. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-29
Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model
41/100 ✓ Peer-reviewed Disease mechanisms Science advances
Key finding: We show that gut dysbiosis occurs in 5xFAD mice, and is associated with escalation of the C/EBPβ/AEP pathway in the gut with age. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-29
It's complicated: The relationship between sleep and Alzheimer's disease in humans
38/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of disease
Key finding: Sleep disturbances have been associated with increased future risk of AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-29
Recommendations of the 5th Canadian Consensus Conference on the diagnosis and treatment of dementia
54/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: We present the results of the 5th CCCDTD, which convened in October 2019, to address topics chosen by the steering committee to reflect advances in the field, and build on previous guidelines.
Full summary, score breakdown and related studies → Original source
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2020-07-28
Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
52/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: We included 201 individuals (mean age 73.5 years, mean BMI 27.4 kg/m2). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-27
Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches
41/100 ✓ Peer-reviewed Disease mechanisms The Lancet. Neurology
Key finding: However, emerging evidence from human and animal studies indicate that insulin influences cerebral bioenergetics, enhances synaptic viability and dendritic spine formation, and increases turnover of neurotransmitters, such as dopamine.
Full summary, score breakdown and related studies → Original source
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2020-07-27
Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer's disease risk
38/100 ✓ Peer-reviewed Prevention trials Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Key finding: With the world's population aging at a rapid rate, the prevalence of Alzheimer's disease (AD) has significantly increased. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-27
A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study
69/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: PE-treated patients performed significantly better than placebo for the co-primary endpoints: change from baseline of Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL; P = .03; 52% less decline) with a trend for Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog; P = .06; 66% less decline) scores at month 14. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-27
Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline
76/100 ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica
Key finding: The results demonstrate that plasma p-tau181 associates better with AD neuropathology and Braak staging than a clinical diagnosis 8 years before post-mortem. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-25
Blood and cerebrospinal fluid neurofilament light differentially detect neurodegeneration in early Alzheimer's disease
48/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: We found that the concentration of NfL in CSF, but not in plasma, was increased in response to Aβ pathology in CU subjects. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-25
Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease
45/100 ✓ Peer-reviewed Biomarkers Molecular neurodegeneration
Key finding: Our results demonstrate that novel AD biomarker candidates are identified and confirmed by proteomic studies of brain tissue and biofluids, providing a rich resource for large-scale biomarker validation for the AD community. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-25
Antihypertensive Deprescribing in Older Adult Veterans at End of Life Admitted to Veteran Affairs Nursing Homes
67/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association
Key finding: Real-world deprescribing patterns of antihypertensives among NH residents with HTN and LLE/AD appear to reflect variation in recommendations for HTN treatment intensity and individualization of patient care in a population with potential overtreatment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-25
A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy
42/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation
Key finding: Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-24
Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases
39/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in integrative neuroscience
Key finding: Patient and animal model studies have found that abnormal protein aggregation of Aβ, synuclein, or copper-zinc superoxide dismutase-1 (SOD1), which are the main proteins expressed in the three diseases, respectively, can activate microglial cells, induce increased interleukin-1β (IL-1β) release, and activate the NLRP3 pathway, leading to neurodegeneration. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-24
Neuroinflammation, microglial activation, and glucose metabolism in neurodegenerative diseases
39/100 ✓ Peer-reviewed Risk factors International review of neurobiology
Key finding: Apart from the plaques and tangles, microglial activation plays a significant role in neurodegeneration and neuronal function.
Full summary, score breakdown and related studies → Original source
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2020-07-24
Multifunctional roles of zinc in Alzheimer's disease
39/100 ✓ Peer-reviewed Drug development Neurotoxicology
Key finding: Emerging evidence demonstrates that zinc is also widely associated with the development of AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-24
Effects of polygenic risk for Alzheimer's disease on rate of cognitive decline in normal aging
66/100 ✓ Peer-reviewed Genetics Translational psychiatry
Key finding: Most people's cognitive abilities decline with age, with significant and partly genetically driven, individual differences in rate of change. +2 more findings
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2020-07-24
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
38/100 ✓ Peer-reviewed Disease mechanisms Nature reviews. Drug discovery
Key finding: The brain requires a continuous supply of energy in the form of ATP, most of which is produced from glucose by oxidative phosphorylation in mitochondria, complemented by aerobic glycolysis in the cytoplasm. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-24
Leading Chronic Disease Prevention With Evidence-Based Policy: The ASTHO Example
27/100 ✓ Peer-reviewed Risk factors Journal of Public Health Management and Practice
Key finding: Many S/THOs focus on improving chronic disease risk factors because of the significant human burden and cost of these conditions. +2 more findings
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2020-07-24
Digital Biomarkers for the Early Detection of Mild Cognitive Impairment: Artificial Intelligence Meets Virtual Reality
45/100 ✓ Peer-reviewed Digital health tools Frontiers in human neuroscience
Key finding: VR can be used to create highly ecologically controlled simulations resembling the daily life contexts in which patients' daily instrumental activities (IADL) usually take place. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-23
Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis
40/100 ✓ Peer-reviewed Disease mechanisms Cell death and differentiation
Key finding: We found that urolithin A-lowered mitochondrial calcium influx significantly alleviated high glucose-induced mtROS accumulation and expression of amyloid beta (Aβ)-producing enzymes, such as amyloid precursor protein (APP) and β-secretase-1 (BACE1), as well as Aβ production. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-23
Health Care Costs of Alzheimer’s and Related Dementias Within a Medicare Managed Care Provider
54/100 ✓ Peer-reviewed Health systems and care delivery Medical Care
Key finding: Total monthly health care costs for individuals with ADRD are statistically greater (P<0.05) than controls beginning in the third month before diagnosis and remain significantly greater through the eighth month following diagnosis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-23
Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
44/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration
Key finding: Alzheimer's Disease (AD) is a neurodegenerative disorder influenced by aging and genetic risk factors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-22
Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Antioxidants (Basel, Switzerland)
Key finding: Neuroinflammation is associated with a large array of neurological disorders for which mitochondrial DAMPs could represent a common thread supporting disease progression.
Full summary, score breakdown and related studies → Original source
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2020-07-22
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease
38/100 ✓ Peer-reviewed Genetics Cell
Key finding: Although complex inflammatory-like alterations are observed around the amyloid plaques of Alzheimer's disease (AD), little is known about the molecular changes and cellular interactions that characterize this response. +4 more findings
Full summary, score breakdown and related studies → Original source
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