Home › Research › Long-term cohort studies
The association between "Brain-Age Score" (BAS) and traditional neuropsychological screening tools in Alzheimer's disease
Beheshti I, Maikusa N, Matsuda H.. Brain and behavior, 2018-06-22
Topic: Amyloid, tau and blood-test diagnosis
Introduction We present the Brain-Age Score (BAS) as a magnetic resonance imaging (MRI)-based index for Alzheimer's disease (AD). We developed a fully automated framework for estimating the BAS in healthy controls (HCs) and individuals with mild cognitive impairment (MCI) or AD, using MRI scans. Methods We trained the proposed framework using 385 HCs from the IXI and OASIS datasets and evaluated 146 HCs, 102 stable-MCI (sMCI), 112 progressive-MCI (pMCI), and 147 AD patients from the J-ADNI dataset.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Beheshti, I., Maikusa, N., & Matsuda, H. (2018). The association between "Brain-Age Score" (BAS) and traditional neuropsychological screening tools in Alzheimer's disease. Brain and behavior. https://doi.org/10.1002/brb3.1020
Vancouver
Beheshti I, Maikusa N, Matsuda H. The association between "Brain-Age Score" (BAS) and traditional neuropsychological screening tools in Alzheimer's disease. Brain and behavior. 2018. doi:10.1002/brb3.1020. PMID: 29931756.
BibTeX
@article{beheshti2018-29931756,
author = {Beheshti, I. and Maikusa, N. and Matsuda, H.},
title = {{The association between "Brain-Age Score" (BAS) and traditional neuropsychological screening tools in Alzheimer's disease}},
journal = {Brain and behavior},
year = {2018},
doi = {10.1002/brb3.1020},
pmid = {29931756},
url = {https://doi.org/10.1002/brb3.1020}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- We developed a fully automated framework for estimating the BAS in healthy controls (HCs) and individuals with mild cognitive impairment (MCI) or AD, using MRI scans.
- Methods We trained the proposed framework using 385 HCs from the IXI and OASIS datasets and evaluated 146 HCs, 102 stable-MCI (sMCI), 112 progressive-MCI (pMCI), and 147 AD patients from the J-ADNI dataset.
- We used a correlation test to determine the association between the BAS and four traditional screening tools of AD: the Mini-Mental State Examination (MMSE), Clinical Dementia Ratio (CDR), Alzheimer's Disease Assessment Score (ADAS), and Functional Assessment Questionnaire (FAQ).
- Furthermore, we assessed the association between BAS and anatomical MRI measurements: the normalized gray matter (nGM), normalized white matter (nWM), normalized cerebrospinal fluid (nCSF), mean cortical thickness as well as hippocampus volume.
Why it matters
This study developed an MRI-based Brain-Age Score and compared it with traditional screening tools for Alzheimer's disease. It is a diagnostic index and does not provide a treatment, cure, or prevention.
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain and behavior) |
| Journal's citation record | 1 / 4 | Brain and Behavior: journal h-index 92 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 89 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.9 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 3 / 6 | Cited 4.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 43 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Hiroshi Matsuda: h-index 64 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | National Center of Neurology and Psychiatry: institution h-index 356 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29931756) |
| Free to read | 2 / 2 | Free to read |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
1 study in the alzhub library lists this one in its references.
Related studies in Long-term cohort studies
Also in Long-term cohort studies
54 studies in the library are filed under Long-term cohort studies with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Long-term cohort studies hub.