Newest studies

Improving comfort around dying in elderly people: a cluster randomised controlled trial

79/100 ✓ Peer-reviewed End-of-life care Lancet (London, England)

Key finding: 451 (11%) of 4241 beds in ten hospitals were included in the analyses. +2 more findings

• Clinical Trials
• End-of-Life Care

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Genome-wide association and interaction studies of CSF T-tau/Aβ42 ratio in ADNI cohort

52/100 ✓ Peer-reviewed Genetics Neurobiology of aging

Key finding: We aim to identify not only SNPs with significant main effects but also SNPs with interaction effects to help explain "missing heritability". +2 more findings

• Genetics
• Biomarkers

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Preventing Burdensome Transitions of Nursing Home Residents with Advanced Dementia: It's More than Advance Directives

38/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine

Key finding: Advance care planning before an acute event is only the first step in a process of decision making.

• End-of-Life Care
• Care Services

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Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): A systematic review and meta-analysis

69/100 ✓ Peer-reviewed Clinical safety Injury

Key finding: LIPUS treatment can be an alternative to surgery for established nonunions. +3 more findings

• Clinical Trials

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Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade

38/100 ✓ Peer-reviewed Risk factors Annual review of biochemistry

Key finding: This phenomenon is associated with a range of increasingly common human disorders, including Alzheimer and Parkinson diseases, type II diabetes, and a number of systemic amyloidoses.

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Alzheimer's disease, dementia, and stem cell therapy

41/100 ✓ Peer-reviewed Disease mechanisms Stem cell research & therapy

Key finding: Alzheimer's disease (AD) represents arguably the most significant social, economic, and medical crisis of our time.

• Treatments

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Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline

60/100 ✓ Peer-reviewed Long-term cohort studies Diabetes care

Key finding: Hemoglobin A 1c (HbA 1c ), a measure of average blood glucose level, is associated with the risk of dementia and cognitive impairment. +3 more findings

• Risk Factors

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The changing prevalence and incidence of dementia over time - current evidence

57/100 ✓ Peer-reviewed How common it is Nature reviews. Neurology

Key finding: To establish clear trends, such comparisons need to be founded on population-based studies that use similar diagnostic and research methods consistently over time. +4 more findings

• Risk Factors

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Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury

40/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of disease

Key finding: APOEε4 allele of human Apolipoprotein E (APOE) gene is the major genetic risk factor for late onset AD and has been associated with chronic traumatic encephalopathy and unfavorable outcome following TBI. +3 more findings

• Genetics
• Risk Factors
• Brain Biology

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Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Continuum

39/100 ✓ Peer-reviewed Disease mechanisms Frontiers in molecular neuroscience

Key finding: Cellular protein quality control relies on multiple strategies, including molecular chaperones, autophagy, the ubiquitin proteasome system, endoplasmic reticulum (ER)-associated degradation (ERAD) and the formation of stress granules (SGs), to regulate proteostasis. +4 more findings

• Other Dementias
• Brain Biology

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Tau pathology and cognitive reserve in Alzheimer's disease

46/100 ✓ Peer-reviewed Risk factors Neurobiology of aging

Key finding: We utilized [18F]AV-1451 positron emission tomography imaging to examine whether high-educated AD patients (n = 12) present more severe tau pathology compared with low-educated patients (n = 12) despite equal clinical severity in regions of interest corresponding to the pathologic disease stages defined by Braak & Braak. +1 more finding

• Brain Biology

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Microbiota-gut-brain axis and the central nervous system

41/100 ✓ Peer-reviewed Disease mechanisms Oncotarget

Key finding: Due to the intricate interactions between the gut and the brain, gut symbiotic microorganisms are closely associated with various CNS diseases, such as Parkinson's disease, Alzheimer's disease, schizophrenia, and multiple sclerosis.

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Physical activity improves cognition: possible explanations

38/100 ✓ Peer-reviewed Prevention trials Biogerontology

Key finding: According to results CA and PA interact, as an increasing PA of only 10% reduces the risk of dementia and AD significantly. +2 more findings

• Lifestyle

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Cerebrospinal fluid Aβ42, t-tau, and p-tau levels in the differential diagnosis of idiopathic normal-pressure hydrocephalus: a systematic review and meta-analysis

62/100 ✓ Peer-reviewed Tau biomarkers Fluids and barriers of the CNS

Key finding: The purpose of this systematic review and meta-analysis was to evaluate the performance of cerebrospinal fluid (CSF) beta amyloid 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) as potential diagnostic biomarkers for idiopathic normal-pressure hydrocephalus (iNPH) and to assess their utility indistinguishing patients with iNPH from those with Alzheimer disease (AD) and healthy normal controls. +3 more findings

• Biomarkers
• Diagnosis

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Impact of multiple pathologies on the threshold for clinically overt dementia

66/100 ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica

Key finding: Many of these findings from pathologic studies, especially for CVD, have been confirmed using sophisticated neuroimaging technologies.

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Alzheimer's disease disrupts alpha and beta-band resting-state oscillatory network connectivity

39/100 ✓ Peer-reviewed Brain scans and imaging Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Key finding: In bilateral parietotemporal areas, oscillatory envelope amplitude increased with healthy ageing, whereas both local amplitude and node-to-global connectivity decreased with AD. +4 more findings

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TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

56/100 ✓ Peer-reviewed Lewy body dementia EMBO reports

Key finding: Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such as Alzheimer's disease and frontotemporal lobar degeneration. +1 more finding

• Brain Biology
• Genetics

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The Exceptional Vulnerability of Humans to Alzheimer's Disease

38/100 ✓ Peer-reviewed Disease mechanisms Trends in molecular medicine

Key finding: Recent research suggests that the crucial link between Aβ aggregation and tauopathy is somehow disengaged in aged monkeys.

• Brain Biology

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Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model

41/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

Key finding: In a previous study, we found that peripheral tissues and organs play important roles in clearing brain-derived Aβ, suggesting that the peripheral approach of removing Aβ from the blood may also be effective for AD therapy. +2 more findings

• Brain Biology
• Digital Tools

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Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

48/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

Key finding: As the primary immune response cell in the central nervous system, microglia constantly monitor the microenvironment and respond rapidly to stress, infection, and injury, making them important modulators of neuroinflammatory responses. +3 more findings

• Brain Biology

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High-resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas

43/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: For both datasets, the new ex vivo atlas significantly outperformed (all p < .05) estimations of the whole amygdala derived from the segmentation in FreeSurfer 5.1 (ADNI: 75%, ABIDE: 54% accuracy), as well as classification based on whole amygdala volume (using the sum of all amygdala nuclei volumes; ADNI: 81%, ABIDE: 55% accuracy).

• Brain Scans

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Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria

59/100 ✓ Peer-reviewed Getting a diagnosis Movement Disorders

Here, we present new criteria aimed to optimize early, sensitive, and specific clinical diagnosis of PSP on the basis of currently available evidence. © 2017 International Parkinson and Movement Disorder Society.

• Diagnosis
• Brain Biology

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Astrocyte dysfunction in Alzheimer disease

45/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroscience research

Key finding: Neurotransmission modulates astrocytic excitability by activating an array of cell surface receptors and transporter proteins, resulting in dynamic changes in intracellular Ca 2+ or Na + . +3 more findings

• Brain Biology

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ApoE influences regional white-matter axonal density loss in Alzheimer's disease

53/100 ✓ Peer-reviewed Genetics Neurobiology of aging

Key finding: NODDI provides tissue-specific microstructural metrics of white-matter tract damage in YOAD, including NDI which correlates with focal cognitive deficits, and APOEε4 status is associated with different patterns of white-matter neurodegeneration.

• Genetics

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Depression as a modifiable factor to decrease the risk of dementia

69/100 ✓ Peer-reviewed Vascular contributions Translational psychiatry

Key finding: This study investigated whether dementia associated with depression decreases with antidepressant use and is independent of the time between exposure to depression and the onset of dementia. +2 more findings

• Risk Factors
• Prevention

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