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Cohort Profile Update: The Irish Longitudinal Study on Ageing (TILDA)
Orna A. Donoghue, Christine Ann McGarrigle, Margaret M. Foley, Andrew J Fagan, James F. Meaney, Rose Anne Kenny. International Journal of Epidemiology, 2018-07-14
Topic: Brain imaging, connectivity and assessment
As outlined in the original cohort profile,1 The Irish Longitudinal Study on Ageing (TILDA) is a prospective cohort study designed to provide an evidence base for addressing the challenges and opportunities associated with population ageing in Ireland. Hypertension affects over 60% of people aged 50 years and over in Ireland,14 and 18.9% of TILDA participants failed to stabilize blood pressure (BP) 30 s after standing.15 This impairment in blood pressure behaviour is associated with poor cognitive function,16 depression17 and unexplained falls,18 and is thought to be linked to impaired cerebral blood perfusion.19 However, it is important to understand which type of blood pressure behaviour (e.g. hypertension, hypotension, increased BP variability) causes the most serious damage to the brain. Compared with Wave 1, a higher proportion of Wave 3 participants completed any health assessment (81% versus 72%) and a home-based assessment (20% versus 14%), reflecting the importance of including this option for older and frailer participants.20,21 Response rates for each Wave of TILDA n/a, not available. Blood sample analytes: lipid profile, folate, Vitamin B12, Vitamin D, Vitamin E, associated with age-related sample hormone Included for a sub-study due to resource (i.e. accelerometers, of MRI Tests included in the TILDA health assessment at each health wave Indicate the wave in which data were collected (i.e. Blood sample analytes: lipid profile, folate, Vitamin B12, Vitamin D, Vitamin E, associated with age-related sample hormone Included for a sub-study due to resource (i.e. accelerometers, of MRI health assessment tests introduced in Wave 3 and the oral health assessment were provided to a subsample of participants due to resource (i.e. accelerometers, of MRI or in the or on an if in the brain of 6 of the or participants from participating in the of the health assessment tests introduced in Wave 3 and the oral health assessment were provided to a subsample of participants due to resource (i.e. accelerometers, of MRI or in the or on an if in the brain of 6 of the or participants from participating in the of the be participants have completed the cardiovascular tests during the health Participants aged years were to of brain changes with Research nurses informed participants the sub-study and provided an and participants were for MRI (see Table were subsequently contacted by to an and Participants were an and a consent TILDA to their general of a consent TILDA i
Key findings
- As outlined in the original cohort profile,1 The Irish Longitudinal Study on Ageing (TILDA) is a prospective cohort study designed to provide an evidence base for addressing the challenges and opportunities associated with population ageing in Ireland.
- Hypertension affects over 60% of people aged 50 years and over in Ireland,14 and 18.9% of TILDA participants failed to stabilize blood pressure (BP) 30 s after standing.15 This impairment in blood pressure behaviour is associated with poor cognitive function,16 depression17 and unexplained falls,18 and is thought to be linked to impaired cerebral blood perfusion.19 However, it is important to understand which type of blood pressure behaviour (e.g. hypertension, hypotension, increased BP variability) causes the most serious damage to the brain.
- Compared with Wave 1, a higher proportion of Wave 3 participants completed any health assessment (81% versus 72%) and a home-based assessment (20% versus 14%), reflecting the importance of including this option for older and frailer participants.20,21 Response rates for each Wave of TILDA n/a, not available.
- Blood sample analytes: lipid profile, folate, Vitamin B12, Vitamin D, Vitamin E, associated with age-related sample hormone Included for a sub-study due to resource (i.e. accelerometers, of MRI Tests included in the TILDA health assessment at each health wave Indicate the wave in which data were collected (i.e.
Study details
- Study designcohort study
- Participants2,525
- Effect size18.9%
- Evidence strengthModerate
How this study scored 71/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 41 of the 58 points we could judge it on, which is 71 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International Journal of Epidemiology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 3 / 4 | 2,525 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30124849) |
| Free to read | 2 / 2 | Free to read |
| Points | 41 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 41 of the 58 points we could judge it on is 71 out of 100. |
| Total | 71 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Donoghue, O. A., McGarrigle, C. A., Foley, M. M., Fagan, A. J., Meaney, J. F., & Kenny, R. A. (2018). Cohort Profile Update: The Irish Longitudinal Study on Ageing (TILDA). International Journal of Epidemiology. https://doi.org/10.1093/ije/dyy163
Vancouver
Donoghue OA, McGarrigle CA, Foley MM, Fagan AJ, Meaney JF, Kenny RA. Cohort Profile Update: The Irish Longitudinal Study on Ageing (TILDA). International Journal of Epidemiology. 2018. doi:10.1093/ije/dyy163. PMID: 30124849.
BibTeX
@article{donoghue2018-30124849,
author = {Donoghue, Orna A. and McGarrigle, Christine Ann and Foley, Margaret M. and Fagan, Andrew J and Meaney, James F. and Kenny, Rose Anne},
title = {{Cohort Profile Update: The Irish Longitudinal Study on Ageing (TILDA)}},
journal = {International Journal of Epidemiology},
year = {2018},
doi = {10.1093/ije/dyy163},
pmid = {30124849},
url = {https://doi.org/10.1093/ije/dyy163}
}
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