Newest studies

Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir

41/100 ✓ Peer-reviewed Brain scans and imaging Journal of molecular biology

Key finding: Here, we describe cryo-EM experiments on tau filaments in the presence and absence of flortaucipir. +4 more findings

• Brain Scans
• Other Dementias

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Shared genetic risk loci between Alzheimer's disease and related dementias, Parkinson's disease, and amyotrophic lateral sclerosis

41/100 ✓ Peer-reviewed Genetics Alzheimer's research & therapy

Key finding: Eleven loci with GWAS hits for one disorder were also associated with one or both of the other disorders: one with all three disorders (the MAPT/KANSL1 locus), five with ADRD and PD (near LCORL, CLU, SETD1A/KAT8, WWOX, and GRN), three with ADRD and ALS (near GPX3, HS3ST5/HDAC2/MARCKS, and TSPOAP1), and two with PD and ALS (near GAK/TMEM175 and NEK1). +4 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Integrating Comorbidity Knowledge for Alzheimer's Disease Drug Repurposing using Multi-task Graph Neural Network

40/100 ✓ Peer-reviewed Drug development AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Key finding: Our pipeline demonstrated a workable strategy that predicts drug candidates with current knowledge of biological interplays between AD and several vascular diseases.

• Treatments
• Digital Tools

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Biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of Alzheimer disease

40/100 ✓ Peer-reviewed Tau biomarkers Neuroscience letters

Key finding: The distribution of neurofibrillary tangles is staged by its involvement starting in the transentorhinal regions of the brain and in final stages progress to neocortices. +3 more findings

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Mild Cognitive Impairment: Data-Driven Prediction, Risk Factors, and Workup

40/100 ✓ Peer-reviewed Getting a diagnosis AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science

Key finding: Our experimental results with logistic regression, random forest, and xgboost models trained and evaluated on more than 531K patient visits show random forest model can predict MCI onset with ROC-AUC of 68.2±0.7.

• Early Stage

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Hearing loss and its link to cognitive impairment and dementia

48/100 ✓ Peer-reviewed Risk factors Frontiers in dementia

Key finding: Indeed, there is a growing body of research that suggests that those who wear hearing aids for age-related hearing problems maintain better cognitive function over time than those who do not.

• Risk Factors

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Clonal hematopoiesis is associated with protection from Alzheimer's disease

80/100 ✓ Peer-reviewed Inflammation and the immune system Nature medicine

Key finding: As CHIP-associated mutations are known to alter the development and function of myeloid cells, we hypothesized that CHIP may also be associated with the risk of Alzheimer's disease (AD), a disease in which brain-resident myeloid cells are thought to have a major role. +4 more findings

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Association between lipocalin-2 and mild cognitive impairment or dementia: A systematic review and meta-analysis of population-based evidence

54/100 ✓ Peer-reviewed Inflammation and the immune system Ageing research reviews

Key finding: In peripheral blood, the overall pooled results showed no significant difference in LCN2 across Alzheimer's disease (AD), MCI and control groups. +2 more findings

• Early Stage

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The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework

49/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: The database search returned 262 results, and after assessment for eligibility, 21 studies were selected. +4 more findings

• Brain Scans

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TFEB is a central regulator of the aging process and age-related diseases

41/100 ✓ Peer-reviewed Disease mechanisms Ageing research reviews

Key finding: Old age is associated with a greater burden of disease, including neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as other chronic diseases.

• Brain Biology

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Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING

41/100 ✓ Peer-reviewed Inflammation and the immune system European journal of pharmacology

Key finding: In this study, we demonstrated that AD transgenic mice exhibited cognitive deficits accompanied by the elevated serum and brain inflammation. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Altered within- and between-network functional connectivity in atypical Alzheimer's disease

57/100 ✓ Peer-reviewed Brain scans and imaging Brain communications

Key finding: Reduced within-network connectivity was observed in the language network in both phenotypes, with stronger evidence of reductions in logopenic progressive aphasia compared to controls. +4 more findings

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Gut microbiome composition may be an indicator of preclinical Alzheimer's disease

59/100 ✓ Peer-reviewed Disease mechanisms Science translational medicine

Key finding: Recent work suggests that the gut microbiome of symptomatic patients with AD has an altered taxonomic composition compared with that of healthy, cognitively normal control individuals. +2 more findings

• Early Stage
• Brain Biology

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Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease

40/100 ✓ Peer-reviewed Drug development Ageing research reviews

Key finding: Epidemiological evidence has revealed a link between AD/PD and type 2 diabetes mellitus, with these disorders sharing some pathological commonalities. +1 more finding

• Treatments

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Reality of Family Caregiving for Hispanics With Alzheimer's Disease and Related Dementias: A Qualitative Analysis

48/100 ✓ Peer-reviewed Caregiving Journal of palliative medicine

Key finding: Four major themes emerged: Methods of Support, Cultural Expectations and Varying Family Contributions, Lack of Self-Care, and Awareness. +4 more findings

• Caregiving

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hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data

43/100 ✓ Peer-reviewed Genetics Cell reports methods

Key finding: Biological systems are immensely complex, organized into a multi-scale hierarchy of functional units based on tightly regulated interactions between distinct molecules, cells, organs, and organisms. +4 more findings

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6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

71/100 ✓ Peer-reviewed Vascular contributions Lancet (London, England)

Key finding: After multivariable adjustment, patients showed an odds ratio (OR) of 1·61 (95% CI 0·80-3·25) for scale 4 versus scale 3 and 4·60 (1·85-11·48) for scale 5-6 versus scale 3 for diffusion impairment; OR 0·88 (0·66-1·17) for scale 4 versus scale 3 and OR 1·76 (1·05-2·96) for scale 5-6 versus scale 3 for anxiety or depression, and OR 0·87 (0·68-1·11) for scale 4 versus scale 3 and 2·75 (1·61-4·69) for scale 5-6 versus scale 3 for fatigue or muscle weakness. +1 more finding

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Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

56/100 ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Neurology

Key finding: Targeting of disease-defining markers in conditions such as Alzheimer disease (amyloid-β and tau) or Parkinson disease (α-synuclein) has been met with limited success, suggesting that these proteins do not act in isolation but form part of a pathological network. +3 more findings

• Brain Biology

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Comparison on cognitive outcomes of antidiabetic agents for type 2 diabetes: A systematic review and network meta-analysis

72/100 ✓ Peer-reviewed Drug development Diabetes/metabolism research and reviews

Key finding: Compared with non-user, SGLT-2i (OR 0.41 [95% CI 0.22-0.76]), GLP-1RA (OR 0.34 [95% CI 0.14-0.85]), thiazolidinedione (OR 0.60 [95% CI 0.51-0.69]), and DPP-4i (OR 0.78 [95% CI 0.61-0.99]) users had a decreased risk of dementia, whereas sulfonylurea (OR 1.43 [95% CI 1.11-1.82]) increased dementia risk. +3 more findings

• Risk Factors
• Treatments

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Stem cell-conditioned medium is a promising treatment for Alzheimer's disease

50/100 ✓ Peer-reviewed Inflammation and the immune system Behavioural brain research

Key finding: The obtained data revealed that MSC-CMs might positively affect neurodegenerative diseases prognosis, especially AD, through various mechanisms, including a decrease in neuro-inflammation, reduction of oxidative stress and Aβ formation, modulation of Microglia function and count, reduction of apoptosis, induction of synaptogenesis and neurogenesis. +2 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

40/100 ✓ Peer-reviewed Risk factors Nutrients

Key finding: The aim of this narrative review was to explore the current understanding of the term neuronutrition as the key concept for brain health, its potential molecular targets, and perspectives of its nutritional approach to the prevention and treatment of Alzheimer's and Parkinson's diseases, multiple sclerosis, anxiety, depressive disorders, migraine, and chronic pain. +4 more findings

• Treatments
• Prevention
• Lifestyle

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Phosphorylated tau in Alzheimer's disease

70/100 ✓ Peer-reviewed Biomarkers Advances in clinical chemistry

Key finding: In advanced stages, all p-tau isoforms are associated with the clinical classification of AD and increase with disease severity, with the greatest increase seen for p-tau217. +1 more finding

• Biomarkers

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Implications of the Approval of Lecanemab for Alzheimer Disease Patient Care: Incremental Step or Paradigm Shift?

71/100 ✓ Peer-reviewed Treatments Neurology

Key finding: Lecanemab (trade name, Leqembi) is the first with published phase 3 trial results. +1 more finding

• Treatments
• Clinical Trials
• Genetics

Full summary, score breakdown and related studies → Original source

Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease

67/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma markers can track biological change over time, with plasma pTau181 and GFAP markers showing longitudinal change in individuals with preclinical AD. +2 more findings

• Biomarkers
• Early Stage
• Genetics

Full summary, score breakdown and related studies → Original source

Revisiting the neuroinflammation hypothesis in Alzheimer's disease: a focus on the druggability of current targets

43/100 ✓ Peer-reviewed Disease mechanisms Frontiers in pharmacology

Key finding: The accumulated evidence on increased levels of inflammatory markers in the cerebrospinal fluid (CSF) of AD patients, along with reports describing CNS alterations caused by senescent immune cells in neuro-degenerative diseases, set out a conceptual framework in which the neuroinflammation hypothesis is being challenged from different angles towards developing new therapies against AD. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source