Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 16,276–16,300 of 27,380 studies, newest first · page 652 of 1096.
March 2016 1
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2016-03 month only
Inequalities in dementia incidence between six racial and ethnic groups over 14 years
68/100 ✓ Peer-reviewed How common it is Alzheimer's & Dementia
Key finding: Dementia incidence highest in African Americans (26.6/1,000 person-years) and American Indian/Alaska Natives (22.2/1,000) +4 more findings
Full summary, score breakdown and related studies → Original source
February 2016 24
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2016-02-29
Beta-Band Functional Connectivity is Reorganized in Mild Cognitive Impairment after Combined Computerized Physical and Cognitive Training
40/100 ✓ Peer-reviewed Prevention trials Frontiers in neuroscience
Key finding: Physical and cognitive idleness constitute significant risk factors for the clinical manifestation of age-related neurodegenerative diseases. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-29
Role of neuroinflammation in neurodegenerative diseases (Review)
48/100 ✓ Peer-reviewed Inflammation and the immune system Molecular medicine reports
Key finding: Neurodegeneration is observed after viral insult and mostly in various so-called 'neurodegenerative diseases', generally observed in the elderly, such as Alzheimer's disease, multiple sclerosis, Parkinson's disease and amyotrophic lateral sclerosis that negatively affect mental and physical functioning. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-28
The relationship between hearing impairment and cognitive function: a meta-analysis in adults
65/100 ✓ Peer-reviewed Prevention and risk Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
Key finding: This meta-analysis suggests that hearing impairment is associated with cognitive problems. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-27
Efficacy of Cholinesterase Inhibitors in Vascular Dementia: An Updated Meta-Analysis
64/100 ✓ Peer-reviewed Treatments European neurology
Key finding: Twelve studies were included in the final analysis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-27
Comparison of predictive modeling approaches for 30-day all-cause non-elective readmission risk
43/100 ✓ Peer-reviewed End-of-life care BMC medical research methodology
Key finding: True predictors can be identified by repeatedly dividing data into fitting/validating subsets and referring the final model based on summarizing results. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-26
Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology
40/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology
Key finding: Microglia in the healthy adult mouse depend on colony-stimulating factor 1 receptor (CSF1R) signalling for survival, and pharmacological inhibition of this receptor results in rapid elimination of nearly all of the microglia in the central nervous system. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-26
The coeruleus/subcoeruleus complex in idiopathic rapid eye movement sleep behaviour disorder
50/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: Here, we studied the integrity of the locus coeruleus/subcoeruleus complex with neuromelanin-sensitive imaging in 21 patients with idiopathic rapid eye movement sleep behaviour disorder and compared the results with those from 21 age- and gender-matched healthy volunteers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-02-26
Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI
48/100 ✓ Peer-reviewed Clinical safety Brain : a journal of neurology
Key finding: Despite the significant impact of postoperative delirium on surgical outcomes and the long-term prognosis of older patients, its neural basis has not yet been clarified. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-26
Canadian Consensus Guidelines on Use of Amyloid Imaging in Canada: Update and Future Directions from the Specialized Task Force on Amyloid imaging in Canada
41/100 ✓ Peer-reviewed Biomarkers The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Key finding: The results of a survey of current practices in Canadian dementia centers were considered.
Full summary, score breakdown and related studies → Original source
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2016-02-25
Emerging Link between Alzheimer's Disease and Homeostatic Synaptic Plasticity
38/100 ✓ Peer-reviewed Disease mechanisms Neural plasticity
Key finding: Although intracellular neurofibrillary tangles and extracellular senile plaques, composed of insoluble amyloid-β (Aβ) peptides, have been the hallmarks of postmortem AD brains, memory impairment in early AD correlates better with pathological accumulation of soluble Aβ oligomers and persistent weakening of excitatory synaptic strength, which is demonstrated by inhibition of long-term potentiation, enhancement of long-term depression, and loss of synapses. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-02-25
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
50/100 ✓ Peer-reviewed Genetics Nature reviews. Neuroscience
Key finding: Furthermore, animal studies have indicated that microglia have an important role in the brain response to amyloid-β (Aβ) plaques and that TREM2 variants may have an impact on such a function. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-02-25
Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD
42/100 ✓ Peer-reviewed Biomarkers Acta neuropathologica communications
Key finding: The hTau40(AT) mice mimic pathological hallmarks of tauopathies including a cognitive phenotype combined with pronounced neuroinflammation visible by bioluminescence. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-02-24
White matter hyperintensities and imaging patterns of brain ageing in the general population
64/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology
Key finding: White matter hyperintensities are associated with increased risk of dementia and cognitive decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-24
Effect of intellectual enrichment on AD biomarker trajectories: Longitudinal imaging study
62/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: There were minimal effects of lifestyle enrichment on AD biomarker trajectories (specifically rates). +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-24
Alzheimer's disease
64/100 ✓ Peer-reviewed Getting a diagnosis Lancet (London, England)
Key finding: Although the prevalence of dementia continues to increase worldwide, incidence in the western world might have decreased as a result of better vascular care and improved brain health. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-02-23
HYDRA: Revealing heterogeneity of imaging and genetic patterns through a multiple max-margin discriminative analysis framework
38/100 ✓ Peer-reviewed Digital health tools NeuroImage
Key finding: The genetics dataset yielded two subtypes of AD characterized mainly by the presence/absence of the apolipoprotein E (APOE) ε4 genotype, but also involving differential presence of risk alleles of CD2AP, SPON1 and LOC39095 SNPs that were associated with differences in the respective patterns of brain atrophy, especially in the precuneus. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-02-23
Combining brain stimulation and video game to promote long-term transfer of learning and cognitive enhancement
40/100 ✓ Peer-reviewed Prevention trials Scientific reports
Key finding: We investigated whether combining transcranial direct current stimulation (tDCS) with cognitive training could further enhance cognitive performance compared to training alone, and promote transfer within a short period of time. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-22
Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry
36/100 ✓ Peer-reviewed Treatments European journal of medicinal chemistry
Key finding: Formation of beta-amyloid species, with different degrees of solubility and neurotoxicity is associated with the gradual decline in cognition leading to dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-02-22
Mini Mental State Examination and Logical Memory scores for entry into Alzheimer's disease trials
52/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's research & therapy
Key finding: Specific cutoff scores on the Mini Mental State Examination (MMSE) and the Logical Memory (LM) test are used to determine inclusion in Alzheimer's disease (AD) clinical trials and diagnostic studies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-22
Predicting Progression from Mild Cognitive Impairment to Alzheimer's Dementia Using Clinical, MRI, and Plasma Biomarkers via Probabilistic Pattern Classification
55/100 ✓ Peer-reviewed Mild cognitive impairment PloS one
Key finding: We developed an accurate prognostic model for predicting MCI-to-dementia progression over a three-year period. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-22
The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer's Disease
43/100 ✓ Peer-reviewed Mild cognitive impairment Cellular and molecular neurobiology
Key finding: There is accumulating evidence suggesting that changes in brain perfusion are present long before the clinical symptoms of Alzheimer's disease (AD), perhaps even before amyloid-β accumulation or brain atrophy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-02-19
Parkinsonism, movement disorders and genetics in frontotemporal dementia
45/100 ✓ Peer-reviewed TREM2 and immune genetics Nature reviews. Neurology
Key finding: FTD often presents in combination with various hyperkinetic or hypokinetic movement disorders, and evidence suggests that various genetic mutations underlie these different presentations. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-19
TREM2 Function in Alzheimer's Disease and Neurodegeneration
45/100 ✓ Peer-reviewed TREM2 and immune genetics ACS chemical neuroscience
Key finding: Alzheimer's disease has a strong genetic component, and recent advances in genome technology have unearthed novel variants in several genes, which could provide insight into the pathogenic mechanisms that contribute to AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-02-19
Olfactory impairment predicts cognitive decline in early Parkinson's disease
53/100 ✓ Peer-reviewed Mild cognitive impairment Parkinsonism & related disorders
Key finding: At baseline, worse olfaction (lowest tertile) was associated with more severe NMS, including anxiety and autonomic symptoms. +1 more finding
Full summary, score breakdown and related studies → Original source
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