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52/100

✓ Peer-reviewed alzhub usefulness score 52 out of 100. Long-term cohort studies

Topic: Amyloid, tau and blood-test diagnosis

Neuropathologic evaluation remains the gold standard for determining the presence and severity of aging-related neurodegenerative diseases. Alzheimer's Disease Centers (ADCs) have worked for >30 years studying human brains, with the goals of achieving new research breakthroughs. Harmonization and sharing among the 39 current and past ADCs is promoted by the National Alzheimer's Coordinating Center (NACC), which collects, audits, and disburses ADC-derived data to investigators on request.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Besser, L. M., Kukull, W. A., Teylan, M. A., Bigio, E. H., Cairns, N. J., Kofler, J. K., et al. (2018). The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses. Journal of neuropathology and experimental neurology. https://doi.org/10.1093/jnen/nly049

Vancouver

Besser LM, Kukull WA, Teylan MA, Bigio EH, Cairns NJ, Kofler JK, et al. The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses. Journal of neuropathology and experimental neurology. 2018. doi:10.1093/jnen/nly049. PMID: 29945202.

BibTeX

@article{besser2018-29945202,
  author  = {Besser, L. M. and Kukull, W. A. and Teylan, M. A. and Bigio, E. H. and Cairns, N. J. and Kofler, J. K. and Montine, T. J. and Schneider, J. A. and others},
  title   = {{The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2018},
  doi     = {10.1093/jnen/nly049},
  pmid    = {29945202},
  url     = {https://doi.org/10.1093/jnen/nly049}
}

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Key findings

Alzheimer's Disease Centers (ADCs) have worked for >30 years studying human brains, with the goals of achieving new research breakthroughs.
Harmonization and sharing among the 39 current and past ADCs is promoted by the National Alzheimer's Coordinating Center (NACC), which collects, audits, and disburses ADC-derived data to investigators on request.
The past decades have witnessed revised disease definitions paired with dramatic expansion in the granularity and multimodality of the collected data.
The NACC database now includes cognitive test scores, comorbidities, drug history, neuroimaging, and links to genomics.

Why it matters

This article describes a revised national form used by Alzheimer's Disease Centers to record brain autopsy findings and share data among researchers. It is a resource for standardizing neuropathology research, not a study of treatment, cure or prevention.

Study details

Evidence strengthLow

How this study scored 52/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of neuropathology and experimental neurology)
Journal's citation record	2 / 4	Journal of Neuropathology & Experimental Neurology: journal h-index 239 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 227 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	22.7 citations a year over 10 year(s) since 2018
Impact for its field and year	4 / 6	Cited 8.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 25 other studies in this library
Still being cited	3 / 4	Cited 120 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Peter T. Nelson: h-index 92 (OpenAlex, whole career)
Institution's track record	3 / 3	University of Washington: institution h-index 3,540 (OpenAlex)
Multicenter collaboration	3 / 3	OpenAlex lists 10 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 29945202)
Free to read	0 / 2	Behind a paywall — scores zero
Total	52 / 100	—

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