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Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1-42
Diaz A, Escobedo C, Treviño S, Chávez R, Lopez-Lopez G, Moran C, Guevara J, Venegas B et al.. Oxidative medicine and cellular longevity, 2018-08-01
Topic: Brain proteins, microglia and lab models
An important worldwide health problem as the result of current lifestyle is metabolic syndrome (MS). It has been shown that MS induced by a high-calorie diet (HCD) in rats produces cognitive deterioration in the novel object recognition test (NORt) and decreases synaptic connections and dendritic order in the hippocampus and temporal cortex. However, it is unknown whether MS induced by an HCD participates in the cognitive process observed with the injection of A β 1-42 into the hippocampus of rats as a model of Alzheimer disease (AD). The induction of MS in rats produces a deterioration in NORt; however, rats with MS injected with A β 1-42 show a major deterioration in the cognitive process. This event could be explained by the increment in the oxidative stress in both cases studied (MS and A β 1-42 ): together, the hippocampus and temporal cortex produce an enhancer effect. In the same way, we observed an increment in interleukin-1 β , TNF- α , and GFAP, indicative of exacerbated inflammatory processes by the combination of MS and A β 1-42 . We can conclude that MS might play a key role in the apparition and development of cognitive disorders, including AD. We propose that metabolic theory is important to explain the apparition of cognitive diseases.
Key findings
- An important worldwide health problem as the result of current lifestyle is metabolic syndrome (MS).
- It has been shown that MS induced by a high-calorie diet (HCD) in rats produces cognitive deterioration in the novel object recognition test (NORt) and decreases synaptic connections and dendritic order in the hippocampus and temporal cortex.
- In the same way, we observed an increment in interleukin-1 β , TNF- α , and GFAP, indicative of exacerbated inflammatory processes by the combination of MS and A β 1-42 .
- We can conclude that MS might play a key role in the apparition and development of cognitive disorders, including AD.
Why it matters
In rats, combining metabolic syndrome with an injection of amyloid beta 1-42 worsened memory and increased markers of oxidative stress and inflammation. This is animal research and does not show any treatment, cure, or prevention for people.
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Study details
- Evidence strengthLow
How this study scored 35/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Oxidative medicine and cellular longevity) |
| Journal's citation record | 2 / 4 | Oxidative Medicine and Cellular Longevity: journal h-index 213 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “rats”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 26 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.6 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 2 / 6 | Cited 1.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Guadalupe Muñoz‐Arenas: h-index 9 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universidad Nacional Autónoma de México: institution h-index 668 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30154946) |
| Free to read | 2 / 2 | Free to read |
| Total | 35 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1155/2018/1358057
- PubMed: 30154946
- Original source →
- Free full text: Oxidative Medicine and Cellular Longevity →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Diaz, A., Escobedo, C., Treviño, S., Chávez, R., Lopez-Lopez, G., Moran, C., et al. (2018). Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1-42. Oxidative medicine and cellular longevity. https://doi.org/10.1155/2018/1358057
Vancouver
Diaz A, Escobedo C, Treviño S, Chávez R, Lopez-Lopez G, Moran C, et al. Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1-42. Oxidative medicine and cellular longevity. 2018. doi:10.1155/2018/1358057. PMID: 30154946.
BibTeX
@article{diaz2018-30154946,
author = {Diaz, A. and Escobedo, C. and Treviño, S. and Chávez, R. and Lopez-Lopez, G. and Moran, C. and Guevara, J. and Venegas, B. and others},
title = {{Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1-42}},
journal = {Oxidative medicine and cellular longevity},
year = {2018},
doi = {10.1155/2018/1358057},
pmid = {30154946},
url = {https://doi.org/10.1155/2018/1358057}
}
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