Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 14,401–14,425 of 27,380 studies, newest first · page 577 of 1096.
January 2018 25
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2018-01-01
Long-Term Safety and Efficacy of Bapineuzumab in Patients with Mild-to-Moderate Alzheimer's Disease: A Phase 2, Open-Label Extension Study
77/100 ✓ Peer-reviewed Treatments Current Alzheimer research
Key finding: No significant difference was seen in cognitive and functional decline between early and delayed treatment groups. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Clinical Evaluation of Amyloid-Related Imaging Abnormalities in Bapineuzumab Phase III Studies
41/100 ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD
Key finding: Overall, ARIA-E was mild and asymptomatic. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Circular RNA and Alzheimer's Disease
38/100 ✓ Peer-reviewed Brain scans and imaging Advances in experimental medicine and biology
Key finding: These circular forms of RNAs are significantly enriched in human brain and retinal tissues. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-01-01
Amyloid Accumulation and Cognitive Decline in Clinically Normal Older Individuals: Implications for Aging and Early Alzheimer's Disease
38/100 ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD
Key finding: Converging evidence across multiple research groups suggests that the presence of abnormal Aβ among CN individuals is associated with elevated risk of future clinical impairment and cognitive decline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models
38/100 ✓ Peer-reviewed Genetics Cell reports
Key finding: Correcting for altered cellular composition of AD tissue, we observed elevated expression of the neurodegeneration-related modules, but also modules not implicated using expression profiles from mouse models alone.
Full summary, score breakdown and related studies → Original source
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2018-01-01
From Cerebrospinal Fluid to Blood: The Third Wave of Fluid Biomarkers for Alzheimer's Disease
38/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: The current blood-derived data are still less clear than those obtained using CSF as the sample type, but independent research suggests that there are biomarker signals in blood that relate to plaque and tangle pathologies in AD, which are relevant to explore further.
Full summary, score breakdown and related studies → Original source
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2018-01-01
A Decade of Blood Biomarkers for Alzheimer's Disease Research: An Evolving Field, Improving Study Designs, and the Challenge of Replication
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: Blood-based biomarkers represent a less invasive and potentially cheaper approach for aiding Alzheimer's disease (AD) detection compared with cerebrospinal fluid and some neuroimaging biomarkers.
Full summary, score breakdown and related studies → Original source
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2018-01-01
Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel Disease
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: With the exception of cortical microinfarcts, all other lesions are well visualized with MRI. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
The Past and the Future of Alzheimer's Disease Fluid Biomarkers
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: In this article in the 20th anniversary issue of the Journal of Alzheimer's Disease, we review the AD biomarkers, from early assay development to their entrance into diagnostic criteria. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Cerebrospinal Fluid Biomarkers for Early and Differential Alzheimer's Disease Diagnosis
41/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: The implementation of the CSF Aβ1-42/Aβ1-40 ratio in the core biomarker panel will improve the biomarker analytical variability, and will also improve early and differential AD diagnosis through a more accurate reflection of pathology. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Assay of Plasma Phosphorylated Tau Protein (Threonine 181) and Total Tau Protein in Early-Stage Alzheimer's Disease
38/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: There was no significant interference from total tau protein in the assay of p-tau181. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study
64/100 ✓ Peer-reviewed Vascular contributions JAMA neurology
Key finding: It is associated with metabolic syndrome, incident diabetes, carotid atherosclerosis, and endothelial dysfunction, conditions that in turn are strongly linked with brain damage and cognitive impairment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Economic Burden, Mortality, and Institutionalization in Patients Newly Diagnosed with Alzheimer's Disease
47/100 ✓ Peer-reviewed End-of-life care Journal of Alzheimer's disease : JAD
Key finding: After controlling for comorbidities, treated AD patients have better survival, lower institutionalization, and sometimes fewer resource utilizations, suggesting that treatment and improved care management could be beneficial for newly-diagnosed AD patients from economic and clinical perspectives. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
The Brain Health Assessment for Detecting and Diagnosing Neurocognitive Disorders
53/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society
Key finding: The BHA had excellent combined sensitivity and specificity to detect dementia and MCI, including MCI due to diverse etiologies. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-01-01
From Research to Application: Supportive and Therapeutic Environments for People Living With Dementia
38/100 ✓ Peer-reviewed End-of-life care The Gerontologist
Key finding: Thus, this article will refer to "individuals living with dementia" as opposed to Alzheimer's disease or other specific forms of dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Long-Term Care Workforce Issues: Practice Principles for Quality Dementia Care
38/100 ✓ Peer-reviewed End-of-life care The Gerontologist
Key finding: Although not all settings currently require attention to the principles described, this article proposes these principles as best practice recommendations.
Full summary, score breakdown and related studies → Original source
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2018-01-01
Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees
53/100 ✓ Peer-reviewed Clinical safety Age and ageing
Key finding: Design diagnostic accuracy study.
Full summary, score breakdown and related studies → Original source
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2018-01-01
Nutrition: Review on the Possible Treatment for Alzheimer's Disease
38/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: Since its discovery some hundred years ago, Alzheimer's disease (AD), a neurodegenerative disease and an eminent cause of most dementia, continues to pose problems for affected families and society, especially in developed countries. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Effect of Multidomain Intervention, Omega-3 Polyunsaturated Fatty Acids Supplementation or their Combinaison on Cognitive Function in Non-Demented Older Adults According to Frail Status: Results from the MAPT Study
67/100 ✓ Peer-reviewed Prevention trials The journal of nutrition, health & aging
Key finding: This population-based study in community-dwellers aged 70 years or over suggested that multidomain intervention and n3 PUFA supplementation have not significant effects on cognitive function change in frail older adults with memory complaints. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Simultaneous Aerobic Exercise and Memory Training Program in Older Adults with Subjective Memory Impairments
74/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: These findings indicate that a 4-week simultaneous memory training and aerobic exercise program is sufficient to improve memory, attention, and reasoning abilities in older adults. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Is Computerized Working Memory Training Effective in Healthy Older Adults? Evidence from a Multi-Site, Randomized Controlled Trial
64/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: Home-based CCT Adaptive WM training appears more effective than Non-Adaptive training in older adults from different cultural backgrounds. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Designing an Internet-Based Multidomain Intervention for the Prevention of Cardiovascular Disease and Cognitive Impairment in Older Adults: The HATICE Trial
70/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: Despite differences in CVR management within the countries considered, it was possible to design and implement the HATICE multidomain intervention. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers
48/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: Prospective studies are needed to validate current findings. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-01
Dietary patterns and cognition in older persons
45/100 ✓ Peer-reviewed Prevention trials Current opinion in clinical nutrition and metabolic care
Key finding: Numerous epidemiological studies have strongly suggested that multinutrient approaches using the Mediterranean diet (Med diet), dietary approach to systolic hypertension (DASH) and the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) are associated with a lower risk of cognitive impairment, MCI and Alzheimer's disease in older persons.
Full summary, score breakdown and related studies → Original source
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2018-01-01
The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study
55/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer's disease : JAD
Key finding: This study found no evidence that major lifestyle factors, aside from smoking, or sleep duration influence the risk of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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