Newest studies

CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection

51/100 ✓ Peer-reviewed TREM2 and immune genetics Neurology(R) neuroimmunology & neuroinflammation

Key finding: CSF sTREM2 increased with systemic and CNS HIV-1 disease severity, with the highest levels found in patients with HIV-associated dementia (HAD). +3 more findings

• Biomarkers
• Genetics
• Brain Biology

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A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18 F-FDG PET of the Brain

48/100 ✓ Peer-reviewed Digital health tools Radiology

Key finding: By using fluorine 18 fluorodeoxyglucose PET of the brain, a deep learning algorithm developed for early prediction of Alzheimer disease achieved 82% specificity at 100% sensitivity, an average of 75.8 months prior to the final diagnosis. © RSNA, 2018 Online supplemental material is available for this article. +2 more findings

• Brain Scans
• Digital Tools
• Diagnosis

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Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Translational neurodegeneration

Key finding: These findings demonstrate that chronic InRapa administration is able to exert a neuroprotective effect on Ts65Dn hippocampus by reducing AD pathological hallmarks and by restoring protein homeostasis, thus ultimately resulting in improved cognition. +4 more findings

• Down Syndrome
• Brain Biology

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Convolutional Neural Networks-Based MRI Image Analysis for the Alzheimer's Disease Prediction From Mild Cognitive Impairment

45/100 ✓ Peer-reviewed Digital health tools Frontiers in neuroscience

Key finding: Compared with other state-of-the-art methods, the proposed one outperforms others with higher accuracy and AUC, while keeping a good balance between the sensitivity and specificity. +1 more finding

• Digital Tools
• Brain Scans
• Early Stage

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Optimal cutoffs for the Montreal Cognitive Assessment vary by race and ethnicity

58/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Our findings suggest cutoffs may need to be stratified by race/ethnicity and education to ensure detecting MCI from normal and MCI from dementia. +1 more finding

• Diagnosis
• Health Equity

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The glymphatic pathway in neurological disorders

57/100 ✓ Peer-reviewed Risk factors The Lancet. Neurology

Key finding: Furthermore, PET studies have revealed that Aβ accumulates in the healthy brain after a single night of sleep deprivation, suggesting that the human glymphatic pathway might also be primarily active during sleep. +2 more findings

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Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease

41/100 ✓ Peer-reviewed Treatments Drug delivery

Key finding: The in vitro assays including dynamic light scattering (DLS), flow cytometry (FCM), red blood cell (RBC) lysis, and thromboelastography (TEG) analysis indicated that this nanoparticle could narrow the diameter of Cur, increase its cellular uptake and possess good blood compatibility. +3 more findings

• Treatments
• Brain Biology

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Medical Use of Cannabinoids

38/100 ✓ Peer-reviewed Brain scans and imaging Drugs

Key finding: As a result, it has been reported that changes in endocannabinoid levels may be related to neurological diseases such as Parkinson's disease, Huntington's disease, Alzheimer's disease and multiple sclerosis, as well as anorexia and irritable bowel syndrome. +3 more findings

• Treatments

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Association of Preclinical Alzheimer Disease With Optical Coherence Tomographic Angiography Findings

59/100 ✓ Peer-reviewed Brain scans and imaging JAMA ophthalmology

Key finding: Fifty-eight eyes from 30 participants (53% female; mean [SD] age, 74.5 [5.6] years; age range, 62-92 years) were included in the analysis. +3 more findings

• Early Stage

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Imaging the evolution and pathophysiology of Alzheimer disease

38/100 ✓ Peer-reviewed Brain scans and imaging Nature reviews. Neuroscience

Key finding: Despite a strong link between Aβ and tau, the relationship between Aβ and neurodegeneration is weak; rather, it is tau that is associated with brain atrophy and hypometabolism, which, in turn, are related to cognition.

• Brain Scans

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Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing

38/100 ✓ Peer-reviewed Brain scans and imaging Nature reviews. Neuroscience

Key finding: Some older adults show little decline in cognitive ability compared with young adults and are thus termed 'optimally ageing'. +1 more finding

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Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

38/100 ✓ Peer-reviewed Genetics Neuron

Key finding: Furthermore, we found striking accumulation of complement C1q in the PSDs of Tau-P301S mice and AD patients. +1 more finding

• Brain Biology

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Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

38/100 ✓ Peer-reviewed Tau biomarkers Nature reviews. Neurology

Key finding: Biomarker discovery and development for clinical research, diagnostics and therapy monitoring in clinical trials have advanced rapidly in key areas of medicine - most notably, oncology and cardiovascular diseases - allowing rapid early detection and supporting the evolution of biomarker-guided, precision-medicine-based targeted therapies. +4 more findings

• Biomarkers

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The Prevalence of Dementia and Cognitive Impairment in Hospitals

59/100 ✓ Peer-reviewed Clinical safety Deutsches Arzteblatt international

Key finding: Two out of five elderly patients in general hospitals suffer from a cognitive disturbance.

• Care Services

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Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial

76/100 ✓ Peer-reviewed Clinical safety JAMA surgery

Key finding: In the primary analysis, limiting the level of sedation provided no significant benefit in reducing incident delirium. +4 more findings

• Clinical Trials

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A comparison of the effects between 2 computerized cognitive training programs, Bettercog and COMCOG, on elderly patients with MCI and mild dementia: A single-blind randomized controlled study

76/100 ✓ Peer-reviewed Prevention trials Medicine

Key finding: There was no significant difference between the two groups in baseline age, sex, illiteracy, years of education, and scores on the K-MMSE, CDR, SNSB-II, and K-MBI. +2 more findings

• Clinical Trials

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Early Life Stress and Epigenetics in Late-onset Alzheimer's Dementia: A Systematic Review

57/100 ✓ Peer-reviewed Disease mechanisms Current genomics

Key finding: Early Life Stress (ELS) rodent models have successfully demonstrated sequelae of maternal separation resulting in LOAD-analogous pathology, thereby supporting a role of insulin receptor signalling pertaining to GSK-3beta facilitated tau hyper-phosphorylation and amyloidogenic processing. +3 more findings

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AGE-FRIENDLY NEW ENGLAND: CREATING HEALTHY AGING DATA REPORTS TO SPUR SOCIAL CHANGE

29/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: Selected results include state rates for MA/RI adults 65+ with: diabetes (32%/36%), hypertension (78%/79%), stroke (13%/13%), Alzheimer’s disease or related dementias (14%/14%), depression (29%/30%), and 4+ chronic conditions (59%/64%).

• Risk Factors
• Policy

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IMPACT OF NEIGHBORHOOD RESOURCES ON HOMEBOUND STATUS

27/100 ✓ Peer-reviewed Health systems and care delivery Innovation in Aging

Key finding: Homebound status is associated with decreased access to medical services and poor health outcomes.

• Care Services

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RICHMOND HEALTH AND WELLNESS PROGRAM: COMMUNITY ADVISORY COUNCIL OUTCOMES

30/100 ✓ Peer-reviewed Risk factors Innovation in Aging

Key finding: In conclusion, themes from the Advisory Council meetings were identified and used to advance resident health and RHWP programming.

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C-Reactive Protein, Plasma Amyloid-β Levels, and Their Interaction With Magnetic Resonance Imaging Markers

59/100 ✓ Peer-reviewed Long-term cohort studies Stroke

Key finding: We hypothesize that CRP (C-reactive protein) is associated with brain structural changes and may interact with amyloid to produce vascular and degenerative damage. +3 more findings

• Brain Scans

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Effective feature learning and fusion of multimodality data using stage-wise deep neural network for dementia diagnosis

50/100 ✓ Peer-reviewed Long-term cohort studies Human brain mapping

Key finding: Multimodality neuroimaging data such as MRI and PET provide valuable insights into brain abnormalities, while genetic data such as single nucleotide polymorphism (SNP) provide information about a patient's AD risk factors. +3 more findings

• Diagnosis
• Brain Scans
• Early Stage

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High-affinity interactions and signal transduction between Aβ oligomers and TREM2

50/100 ✓ Peer-reviewed TREM2 and immune genetics EMBO molecular medicine

Key finding: We assessed binding of TREM2, AD-associated TREM2 variants to various forms of Aβ and APOE in multiple assays. +3 more findings

• Genetics
• Brain Biology

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TREM2 - a key player in microglial biology and Alzheimer disease

54/100 ✓ Peer-reviewed Risk genes beyond APOE Nature reviews. Neurology

Key finding: Familial AD typically results from mutations in the genes encoding amyloid precursor protein (APP), presenilin 1 or presenilin 2. +3 more findings

• Genetics
• Brain Biology

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Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment

73/100 ✓ Peer-reviewed Mild cognitive impairment The Cochrane database of systematic reviews

Key finding: It has been suggested that various different vitamin and mineral supplements might be useful in maintaining cognitive function and delaying the onset of dementia. +4 more findings

• Early Stage
• Lifestyle
• Prevention

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