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73/100

✓ Peer-reviewed alzhub usefulness score 73 out of 100. Mild cognitive impairment

Topic: Risk, prevention and care in population studies

It has been suggested that various different vitamin and mineral supplements might be useful in maintaining cognitive function and delaying the onset of dementia. Data collection and analysis We sought data on our primary outcomes of dementia incidence and overall cognitive function and on secondary outcomes of episodic memory, executive function, speed of processing, quality of life, functional performance, clinical global impression, adverse events, and mortality. We used GRADE methods to assess the overall quality of evidence for each comparison and outcome. Main results We included five trials with 879 participants which investigated B vitamin supplements. Our primary efficacy outcomes were the incidence of dementia and scores on measures of overall cognitive function. None of the trials reported the incidence of dementia and the evidence on overall cognitive function was of very low-quality. The available data did not allow us to conduct analyses, but the authors reported no significant effect of three years of supplementation with vitamin E on overall cognitive function, episodic memory, speed of processing, clinical global impression, functional performance, adverse events, or mortality (five deaths in each group).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

McCleery, J., Abraham, R. P., Denton, D. A., Rutjes, A. W., Chong, L. Y., Al-Assaf, A. S., et al. (2018). Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment. The Cochrane database of systematic reviews. https://doi.org/10.1002/14651858.cd011905.pub2

Vancouver

McCleery J, Abraham RP, Denton DA, Rutjes AW, Chong LY, Al-Assaf AS, et al. Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment. The Cochrane database of systematic reviews. 2018. doi:10.1002/14651858.cd011905.pub2. PMID: 30383288.

BibTeX

@article{mccleery2018-30383288,
  author  = {McCleery, J. and Abraham, R. P. and Denton, D. A. and Rutjes, A. W. and Chong, L. Y. and Al-Assaf, A. S. and Griffith, D. J. and Rafeeq, S. and others},
  title   = {{Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2018},
  doi     = {10.1002/14651858.cd011905.pub2},
  pmid    = {30383288},
  url     = {https://doi.org/10.1002/14651858.cd011905.pub2}
}

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Key findings

It has been suggested that various different vitamin and mineral supplements might be useful in maintaining cognitive function and delaying the onset of dementia.
Data collection and analysis We sought data on our primary outcomes of dementia incidence and overall cognitive function and on secondary outcomes of episodic memory, executive function, speed of processing, quality of life, functional performance, clinical global impression, adverse events, and mortality.
We used GRADE methods to assess the overall quality of evidence for each comparison and outcome.
Main results We included five trials with 879 participants which investigated B vitamin supplements.
Our primary efficacy outcomes were the incidence of dementia and scores on measures of overall cognitive function.

Why it matters

This review of five trials with 879 participants found no significant effect of three years of vitamin E supplementation on overall cognitive function or other outcomes, and none of the trials reported dementia incidence. The evidence on overall cognitive function was of very low quality.

Study details

Study designsystematic review
Participants516
Effect sizeHR 1.02
Evidence strengthHigh

How this study scored 73/100

Published in a leading specialty journal, and it is a systematic review of all the studies on the question.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (The Cochrane database of systematic reviews)
Journal's citation record	3 / 4	Cochrane Database of Systematic Reviews: journal h-index 468 (OpenAlex, 2026-10-29)
Study design	12 / 12	A systematic review of all the studies on the question
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	2 / 4	516 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	A review of other studies — randomization is not credited here
Times cited	5 / 7	Cited 160 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	16.0 citations a year over 10 year(s) since 2018
Impact for its field and year	4 / 6	Cited 11.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 5 other studies in this library
Still being cited	2 / 4	Cited 34 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Naji Tabet: h-index 37 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Bern: institution h-index 977 (OpenAlex)
Multicenter collaboration	3 / 3	OpenAlex lists 16 institution(s) in 6 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 30383288)
Free to read	0 / 2	Behind a paywall — scores zero
Total	73 / 100	—

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