Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,001–26,025 of 27,380 studies, newest first · page 1041 of 1096.
March 1998 6
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1998-03-01
Delirium risk factors in elderly hospitalized patients
66/100 ✓ Peer-reviewed Risk factors Journal of general internal medicine
Key finding: Despite methodologic limitations, certain risk factors for delirium seem to be consistent and could help identify high-risk patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-03-01
Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype
49/100 ✓ Peer-reviewed Risk factors Archives of neurology
Key finding: Neocortical neurofibrillary tangle densities were substantially correlated with dementia severity, and to a greater degree than was true for senile plaque densities. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-03-01
Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men
60/100 ✓ Peer-reviewed How common it is Hypertension (Dallas, Tex. : 1979)
Key finding: Cross-sectional measurements at age 70 showed that high 24-hour BP, nondipping, insulin resistance, and diabetes all were related to low cognitive function. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-03-01
Cognitive function and dementia in six areas of England and Wales: the distribution of MMSE and prevalence of GMS organicity level in the MRC CFA Study. The Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
48/100 ✓ Peer-reviewed Disparities Psychological medicine
Key finding: Prevalence of cognitive impairment and dementia appear not to vary widely across the centres examined in this study, which provides stable estimates by age and sex for AGECAT O3 and above, and norms for MMSE. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-03-01
Estrogen therapy in postmenopausal women: effects on cognitive function and dementia
70/100 ✓ Peer-reviewed Prevention and risk JAMA
Key finding: Meta-analysis of these studies suggests a 29% decreased risk of developing dementia among estrogen users, but the findings of the studies are heterogeneous. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-03-01
The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics
70/100 ✓ Peer-reviewed Genetics JAMA
Key finding: The presence of an APOE-epsilon4 allele is a determinant of AD risk in whites, but African Americans and Hispanics have an increased frequency of AD regardless of their APOE genotype. +1 more finding
Full summary, score breakdown and related studies → Original source
February 1998 9
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1998-02-01
Validity of diagnostic and drug data in standardized nursing home resident assessments: potential for geriatric pharmacoepidemiology. SAGE Study Group. Systematic Assessment of Geriatric drug use via Epidemiology
36/100 ✓ Peer-reviewed Costs and economics Medical care
Key finding: Limited to individuals who had been hospitalized in the 6 months preceding the first assessment, Minimum Data Set diagnoses were compared with those on the hospital discharge claims maintained in the Medicare Provider Analysis and Review database. +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-02-01
Assessing the impact of neuropsychiatric symptoms in Alzheimer's disease: the Neuropsychiatric Inventory Caregiver Distress Scale
50/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society
Key finding: The NPI-D provides a reliable and valid measure of subjective caregiver distress in relation to neuropsychiatric symptoms measured by the NPI. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-02-01
The relationship between quantitative MRI and neuropsychological functioning in temporal lobe epilepsy
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Epilepsia
Key finding: Our results provide some support for the lateralised model of material specific memory deficits, but suggest that a number of demographic and epilepsy-related factors may interact with the extent and laterality of hippocampal pathology in shaping the nature of the associated neuropsychological deficit. +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-02-01
Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease: an interim analysis of the results of a US multicentre open label extension study
65/100 ✓ Peer-reviewed Treatments European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Key finding: Assessments were conducted at three-weekly intervals for 12 weeks, then 12-weekly for up to 192 weeks. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-02-01
Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders
44/100 ✓ Peer-reviewed Lewy body dementia The American journal of pathology
Key finding: Recent studies have shown that a mutation in NACP is associated with familial Parkinson's disease, and that Lewy bodies are immunoreactive with antibodies against this molecule. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-02-01
The value of the Rivermead Behavioural Memory Test (Children's Version) in an epidemiological study of older adults with Down syndrome
46/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The British journal of clinical psychology
Key finding: We also investigated whether there was a significant difference in everyday memory performance between different age, gender and day-centre groups. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-02-01
Natural history and survival of 14 patients with corticobasal degeneration confirmed at postmortem examination
47/100 ✓ Peer-reviewed Disparities Journal of neurology, neurosurgery, and psychiatry
Key finding: The results confirm that unilateral parkinsonism unresponsive to levodopa and limb ideomotor apraxia are the clinical hallmarks of corticobasal degeneration, and only a minority of patients with corticobasal degeneration present with dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-02-01
Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study
48/100 ✓ Peer-reviewed Disparities Stroke
Key finding: We determined the relationship between apolipoprotein (Apo)E, MRI, and low cognitive scores.
Full summary, score breakdown and related studies → Original source
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1998-02-01
Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease
61/100 ✓ Peer-reviewed Getting a diagnosis The New England journal of medicine
Key finding: APOE genotyping does not provide sufficient sensitivity or specificity to be used alone as a diagnostic test for Alzheimer's disease, but when used in combination with clinical criteria, it improves the specificity of the diagnosis. +4 more findings
Full summary, score breakdown and related studies → Original source
January 1998 10
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1998-01-05
EEG slowing and cerebrospinal fluid tau levels in patients with cognitive decline
45/100 ✓ Peer-reviewed Tau biomarkers Neuroreport
Key finding: There were no significant correlations between EEG slowing and CSF tau levels in 12 patients with mild cognitive dysfunction or in 14 healthy control subjects.
Full summary, score breakdown and related studies → Original source
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1998-01-01
Microglial response to amyloid plaques in APPsw transgenic mice
40/100 ✓ Peer-reviewed Inflammation and the immune system Europe PMC (PubMed Central)
Key finding: A recently described mouse line, Tg(HuAPP695.K670N/M671L)2576, expressing human amyloid precursor protein with a familial AD gene mutation, age-related amyloid deposits, and memory deficits, was found to develop a significant microglial response using Griffonia simplicifolia lectin or phosphotyrosine probe to identify microglia Both Griffonia simplicifolia lectin and phosphotyrosine staining showed increased numbers of intensely labeled, often enlarged microglia clustered in and around plaques, consistent with microglial activation related to beta-amyloid formation. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-01-01
Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Science (New York, N.Y.)
Key finding: The cerebral cortex of Alzheimer's and Down syndrome patients is characterized by the presence of protein deposits in neurofibrillary tangles, neuritic plaques, and neuropil threads. +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-01-01
Efficacy and tolerability of carbamazepine for agitation and aggression in dementia
50/100 ✓ Peer-reviewed Health systems and care delivery The American journal of psychiatry
Key finding: This controlled study showed significant short-term efficacy of carbamazepine for agitation with generally good safety and tolerability. +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-01-01
Cyclooxygenases 1 and 2
36/100 ✓ Peer-reviewed Inflammation and the immune system Annual review of pharmacology and toxicology
Key finding: Protective PGs, which preserve the integrity of the stomach lining and maintain normal renal function in a compromised kidney, are synthesized by COX-1. +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-01-01
Susac syndrome
41/100 ✓ Peer-reviewed Risk factors Medicine
Key finding: Some infarcts may be asymptomatic and only revealed by ancillary investigation: 1) audiogram that shows bilateral sensorineural hearing loss predominating on low frequencies, 2) funduscopy and fluorescein retinal angiography demonstrating bilateral distal branch retinal artery occlusions, and 3) brain MRI T2-weighted images disclosing small multifocal hyperintensities in white and gray matter.
Full summary, score breakdown and related studies → Original source
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1998-01-01
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
41/100 ✓ Peer-reviewed Risk genes beyond APOE Nature
Key finding: They result in a selective increase in the production of the amyloidogenic peptide amyloid-beta(1-42) by proteolytic processing of the amyloid precursor protein (APP). +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-01-01
Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease
40/100 ✓ Peer-reviewed Genetics Neuroepidemiology
Key finding: The epsilon 4 allele of the apolipoprotein E (apoE) is associated with Alzheimer's disease (AD) and also with elevated serum total cholesterol and low-density lipoprotein levels. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-01-01
Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease
36/100 ✓ Peer-reviewed Biomarkers Brain research
Key finding: Inflammatory processes may play a critical role in the pathogenesis of the degenerative changes and cognitive impairments associated with Alzheimer's disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-01-01
Clinical determinants of poststroke dementia
50/100 ✓ Peer-reviewed Vascular contributions Stroke
Key finding: Our data suggest that a single explanation for poststroke dementia is not adequate; rather, multiple factors including stroke features (dysphasia, major dominant stroke syndrome), host characteristics (educational level), and prior cerebrovascular disease each independently contribute to the risk. +2 more findings
Full summary, score breakdown and related studies → Original source
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