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Centiloid scaling for quantification of brain amyloid with [ 18 F]flutemetamol using multiple processing methods
Battle MR, Pillay LC, Lowe VJ, Knopman D, Kemp B, Rowe CC, Doré V, Villemagne VL et al.. EJNMMI research, 2018-12-05
Topic: Plasma and spinal-fluid biomarkers
Introduction A standardised method for quantifying β-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a common scale to better aid the diagnosis and prognosis of Alzheimer's disease (AD) and to monitor anti-amyloid therapeutic interventions. Here, we apply the Centiloid method to [ 18 F]flutemetamol and [ 11 C]PiB (PiB, Pittsburgh compound B) PET images and derive the scaling factor to express their binding in Centiloids. Methods Paired PiB and [ 18 F]flutemetamol scans for 74 subjects, including 24 young healthy controls (37 ± 5 years), were analysed using the standard Centiloid method. The same subjects were also analysed using PMOD- and FSL-based pipelines as well as SPM8. Test-retest analysis of 10 AD subjects was also performed with each pipeline. Results The standard uptake value ratios (SUVR), determined using the standard SPM8 Centiloid process, showed a strong correlation between [ 18 F]flutemetamol (Flute) and PiB binding (SUVR-Flute = 0.77 × SUVR-PiB + 0.22, R 2 = 0.96). Application of the standard Centiloid process allowed the calculation of a direct conversion equation for SUVR-Flute to Centiloid units (CL) (CL = (121.42*SUVR-Flute) - 121.16). Analysis of the data via the two alternate Centiloid pipelines allowed us to derive standardised, SPM8-equivalent equations for both PMOD (CL = (115.24*SUVR-Flute) - 107.86) and FSL (CL = (120.32*SUVR-Flute) - 112.75) respectively. Test-retest analysis of 10 AD subjects showed an approximate 2% difference for each pipeline. Conclusions [ 18 F]flutemetamol data can now be expressed in Centiloid units, enhancing its utility in clinical and research applications for β-amyloid imaging. The standard Centiloid method also demonstrates that [ 18 F]flutemetamol has favourable performance compared with PiB and other β-amyloid tracers. Test-retest difference averaged 2%, with no difference between image processing pipelines. Centiloid scaling is robust and can be implemented on a number of platforms.
Key findings
- Results The standard uptake value ratios (SUVR), determined using the standard SPM8 Centiloid process, showed a strong correlation between [ 18 F]flutemetamol (Flute) and PiB binding (SUVR-Flute = 0.77 × SUVR-PiB + 0.22, R 2 = 0.96).
- The standard Centiloid method also demonstrates that [ 18 F]flutemetamol has favourable performance compared with PiB and other β-amyloid tracers.
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Study details
- Participants74
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 28 of the 58 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (EJNMMI research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 74 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30519791) |
| Free to read | 2 / 2 | Free to read |
| Points | 28 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 28 of the 58 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
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APA 7th
Battle, M. R., Pillay, L. C., Lowe, V. J., Knopman, D., Kemp, B., Rowe, C. C., et al. (2018). Centiloid scaling for quantification of brain amyloid with [ 18 F]flutemetamol using multiple processing methods. EJNMMI research. https://doi.org/10.1186/s13550-018-0456-7
Vancouver
Battle MR, Pillay LC, Lowe VJ, Knopman D, Kemp B, Rowe CC, et al. Centiloid scaling for quantification of brain amyloid with [ 18 F]flutemetamol using multiple processing methods. EJNMMI research. 2018. doi:10.1186/s13550-018-0456-7. PMID: 30519791.
BibTeX
@article{battle2018-30519791,
author = {Battle, M. R. and Pillay, L. C. and Lowe, V. J. and Knopman, D. and Kemp, B. and Rowe, C. C. and Doré, V. and Villemagne, V. L. and others},
title = {{Centiloid scaling for quantification of brain amyloid with [ 18 F]flutemetamol using multiple processing methods}},
journal = {EJNMMI research},
year = {2018},
doi = {10.1186/s13550-018-0456-7},
pmid = {30519791},
url = {https://doi.org/10.1186/s13550-018-0456-7}
}
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