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Practical Small Vessel Disease Score Relates to Stroke, Dementia, and Death
Yilmaz P, Ikram MK, Niessen WJ, Ikram MA, Vernooij MW.. Stroke, 2018-12-01
Topic: Risk, prevention and care in population studies
Background and Purpose- In the general population, we investigated the association of a recently developed cerebral small vessel disease (CSVD) sum score with stroke, dementia, and mortality. Methods- One thousand six hundred fifty-one stroke-free and nondemented participants (mean age, 73.3 years; 54.5% women) of the population-based Rotterdam Study underwent brain magnetic resonance imaging (1.5T) in 2005-2011 and were followed for stroke, dementia, and mortality until 2016-2017. The CSVD sum score was composed by counting the presence of 4 magnetic resonance imaging markers (white matter hyperintensities, lacunes, cerebral microbleeds, and perivascular spaces; range, 0-4).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Yilmaz, P., Ikram, M. K., Niessen, W. J., Ikram, M. A., & Vernooij, M. W. (2018). Practical Small Vessel Disease Score Relates to Stroke, Dementia, and Death. Stroke. https://doi.org/10.1161/strokeaha.118.022485
Vancouver
Yilmaz P, Ikram MK, Niessen WJ, Ikram MA, Vernooij MW. Practical Small Vessel Disease Score Relates to Stroke, Dementia, and Death. Stroke. 2018. doi:10.1161/strokeaha.118.022485. PMID: 30571403.
BibTeX
@article{yilmaz2018-30571403,
author = {Yilmaz, P. and Ikram, M. K. and Niessen, W. J. and Ikram, M. A. and Vernooij, M. W.},
title = {{Practical Small Vessel Disease Score Relates to Stroke, Dementia, and Death}},
journal = {Stroke},
year = {2018},
doi = {10.1161/strokeaha.118.022485},
pmid = {30571403},
url = {https://doi.org/10.1161/strokeaha.118.022485}
}
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Key findings
- Methods- One thousand six hundred fifty-one stroke-free and nondemented participants (mean age, 73.3 years; 54.5% women) of the population-based Rotterdam Study underwent brain magnetic resonance imaging (1.5T) in 2005-2011 and were followed for stroke, dementia, and mortality until 2016-2017.
- The CSVD sum score was composed by counting the presence of 4 magnetic resonance imaging markers (white matter hyperintensities, lacunes, cerebral microbleeds, and perivascular spaces; range, 0-4).
- We determined the association of the CSVD score with risk of stroke, dementia, and mortality using Cox models, adjusting for age, sex, and other Framingham Stroke Risk Profile predictors.
- Additionally, we assessed mortality as a competing risk for stroke and dementia and calculated absolute risk estimates for all outcomes.
Why it matters
This study found that a cerebral small vessel disease score based on brain MRI markers was related to stroke, dementia, and death in a population-based cohort. It does not show that treating small vessel disease prevents dementia, and the findings are observational.
Study details
- Participants66
- Effect size54.5%
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Stroke) |
| Journal's citation record | 3 / 4 | Stroke: journal h-index 455 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 66 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 85 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.5 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 3 / 6 | Cited 4.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 2 / 4 | Cited 32 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Meike Willemijn Vernooij: h-index 99 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30571403) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 49 / 100 | — |
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