Home › Research › Risk genes beyond APOE
Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage
Zhang M, Cheng X, Dang R, Zhang W, Zhang J, Yao Z.. Journal of neuropathology and experimental neurology, 2018-12-01
Topic: Amyloid, tau and blood-test diagnosis
Cerebral energy metabolism in Alzheimer disease (AD) has recently been given increasing attention. This study focuses on the alterations of cerebral lactate metabolism in the double-transgenic amyloid precursor protein/presenilin 1 (APP/PS1) mouse model of AD. Immunofluorescence staining and Western blotting analysis were used to identify the alterations of lactate content and lactate transporters (MCT1, MCT2, MCT4) in APP/PS1 mouse brains, which display amyloid beta plaques, reduced amounts of neurons and oligodendrocytes, and increased quantity of astrocytes.
Key findings
- This study focuses on the alterations of cerebral lactate metabolism in the double-transgenic amyloid precursor protein/presenilin 1 (APP/PS1) mouse model of AD.
- Immunofluorescence staining and Western blotting analysis were used to identify the alterations of lactate content and lactate transporters (MCT1, MCT2, MCT4) in APP/PS1 mouse brains, which display amyloid beta plaques, reduced amounts of neurons and oligodendrocytes, and increased quantity of astrocytes.
- We found that lactate content and expressions of cerebral MCT1, MCT2, and MCT4 were decreased in APP/PS1 mice.
- In particular, lactate dehydrogenase A (LDHA) and B (LDHB) were reduced in neurons with increased ratios of LDHA and LDHB.
Why it matters
In the APP/PS1 mouse model of Alzheimer disease, the study found alterations in lactate content and lactate transporters in the brain. This is animal research on energy metabolism and does not show any treatment, cure or prevention for people.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuropathology and experimental neurology) |
| Journal's citation record | 2 / 4 | Journal of Neuropathology & Experimental Neurology: journal h-index 239 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mouse”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 129 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.9 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 3 / 6 | Cited 3.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 64 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Zhongxiang Yao: h-index 22 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Army Medical University: institution h-index 478 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30383244) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Zhang, M., Cheng, X., Dang, R., Zhang, W., Zhang, J., & Yao, Z. (2018). Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage. Journal of neuropathology and experimental neurology. https://doi.org/10.1093/jnen/nly102
Vancouver
Zhang M, Cheng X, Dang R, Zhang W, Zhang J, Yao Z. Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage. Journal of neuropathology and experimental neurology. 2018. doi:10.1093/jnen/nly102. PMID: 30383244.
BibTeX
@article{zhang2018-30383244,
author = {Zhang, M. and Cheng, X. and Dang, R. and Zhang, W. and Zhang, J. and Yao, Z.},
title = {{Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage}},
journal = {Journal of neuropathology and experimental neurology},
year = {2018},
doi = {10.1093/jnen/nly102},
pmid = {30383244},
url = {https://doi.org/10.1093/jnen/nly102}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.