Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 25,926–25,950 of 27,380 studies, newest first · page 1038 of 1096.

August 1998 5

  1. 1998-08-01

    What is the amygdala?

    ✓ Peer-reviewed Lewy body dementia Trends in neurosciences

    Key finding: Cell groups within it appear to be differentiated parts of the traditional cortex, the claustrum, or the striatum, and these parts belong to four obvious functional systems--accessory olfactory, main olfactory, autonomic and frontotemporal cortical. +4 more findings

  2. 1998-08-01

    Naming in semantic dementia--what matters?

    ✓ Peer-reviewed Digital health tools Neuropsychologia

    Key finding: The analyses showed that object familiarity, word frequency and age-of-acquisition predicted naming success for the group and, in most cases, for each individual patient, irrespective of lesion site or overall naming success. +1 more finding

  3. 1998-08-01

    Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity

    ✓ Peer-reviewed Genetics JAMA

    Key finding: Using parametric methods, no evidence for linkage to the region spanned by the chromosome 12 markers could be detected if familial AD is assumed to arise from the same genetic locus in all 53 families. +1 more finding

  4. 1998-08-01

    Alpha-2 macroglobulin is genetically associated with Alzheimer disease

    ✓ Peer-reviewed Genetics Nature genetics

    Key finding: Analysis of a deletion in the A2M gene at the 5' splice site of 'exon II' of the bait region (exon 18) revealed that inheritance of the deletion (A2M-2) confers increased risk for AD (Mantel-Haenzel odds ratio=3.56, P=0.001). +2 more findings

  5. 1998-08-01

    Intracerebroventricular administration of quinolinic acid induces a selective decrease of inositol(1,4,5)-trisphosphate receptor in rat brain

    ✓ Peer-reviewed Biomarkers Neurochemistry international

    Key finding: In addition, previous results obtained from brains of Alzheimer patients indicated a reduction of IP3-receptor protein correlated to neuronal loss. +1 more finding

July 1998 13

  1. 1998-07-01

    Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease

    ✓ Peer-reviewed Treatments Clinical therapeutics

    Key finding: Both preclinical studies and studies in human volunteers have shown that rivastigmine induces substantially greater inhibition of AChE in the central nervous system (CNS) compartment than in the periphery (40% inhibition of central AChE compared with 10% inhibition of plasma butylcholinesterase in healthy volunteers). +3 more findings

  2. 1998-07-01

    Demographic and epidemiological determinants of healthcare costs in Netherlands: cost of illness study

    ✓ Peer-reviewed Vascular contributions BMJ (Clinical research ed.)

    Key finding: The main determinants of healthcare use in the Netherlands are old age and disabling conditions, particularly mental disability.

  3. 1998-07-01

    Measuring quality of life for patients with terminal illness: the Missoula-VITAS quality of life index

    ✓ Peer-reviewed End-of-life care Palliative medicine

    Key finding: The MVQOLI demonstrated internal consistency (Cronbach's alpha = 0.77).

  4. 1998-07-01

    Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Archives of neurology

    Key finding: Previous data from familial AD due to mutations in presenilin 1 and presenilin 2 genes and the amyloid precursor protein suggest that the long form of Abeta peptide, Abeta42, is selectively increased in these circumstances. +2 more findings

  5. 1998-07-01

    Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease

    ✓ Peer-reviewed Cognitive tests and assessment Neurology

    Key finding: Prior studies report that subjects with neuropathologic evidence of AD and concomitant brain infarcts had poorer cognitive function and higher frequency of dementia than those with AD alone. +3 more findings

  6. 1998-07-01

    Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

    ✓ Peer-reviewed Lewy body dementia Neuroscience letters

    Key finding: These findings provide an unexpected link between multiple system atrophy and Lewy body disorders and establish that alpha-synucleinopathies constitute a major class of human neurodegenerative disorder.

  7. 1998-07-01

    Effect of long term bed rest in men on enzymatic antioxidative defence and lipid peroxidation in erythrocytes

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology

    Key finding: However, bed rest results in many alterations which are disadavantageous. +1 more finding

  8. 1998-07-01

    The prevalence and 3-year incidence of dementia in older Black and White community residents

    ✓ Peer-reviewed Disparities Journal of clinical epidemiology

    Key finding: Prevalence, 3-year incidence, and types of dementia are comparable in Black and White elderly in the Piedmont area of North Carolina. +2 more findings

  9. 1998-07-01

    Dementia caregiver burden: a review of the literature and guidelines for assessment and intervention

    ✓ Peer-reviewed Caregiving Neurology

    Key finding: Although caregiving is associated with significant psychological and physical morbidity, there are wide individual differences among caregivers in how well they adapt to caregiving demands. +1 more finding

  10. 1998-07-01

    Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities

    ✓ Peer-reviewed Getting a diagnosis Neurology

    Key finding: The most proximal brain events associated with the clinical expression of dementia are progressive neuronal dysfunction and loss of neurons in specific regions of the brain.

  11. 1998-07-01
  12. 1998-07-01

    Microglial activation in Alzheimer disease: Association with APOE genotype

    ✓ Peer-reviewed Genetics Brain pathology (Zurich, Switzerland)

    Key finding: Abeta is bound by apolipoprotein E (APOE) in an isoform-specific manner, and it has been demonstrated that inheritance of the AD susceptibility allele, APOE epsilon4, is associated with increased deposition of Abeta in the cerebral cortex. +2 more findings

  13. 1998-07-01

June 1998 7

  1. 1998-06-01

    The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation

    ✓ Peer-reviewed Drug development Brain research. Molecular brain research

    Key finding: Prominent neurodegeneration and glial activation occurs around these plaques leading to the hypothesis that Abeta may play a causative role in the neuronal loss and the inflammatory response associated with AD. +3 more findings

  2. 1998-06-01

    Amygdala core nuclei volumes are decreased in recurrent major depression

    ✓ Peer-reviewed Hippocampus size on brain scans Neuroreport

    Key finding: Depressed subjects had bilaterally reduced amygdala core nuclei volumes and no significant differences in total amygdala volumes or in whole brain volumes.

  3. 1998-06-01

    The neuropathology of a chromosome 17-linked autosomal dominant parkinsonism and dementia ("pallido-ponto-nigral degeneration")

    ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology

    Key finding: First, we showed that PPND is characterized by abundant ballooned neurons in neocortical and subcortical regions as well as by tau-rich inclusions in the cytoplasm of neurons and oligodendroglia morphologically similar to those seen in corticobasal degeneration (CBD), but in a distribution pattern resembling progressive supranuclear palsy (PSP). +3 more findings

  4. 1998-06-01

    Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging

    ✓ Peer-reviewed Brain tissue and pathology Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    Key finding: Extensive evidence implicates a deficit in serotonergic neurotransmission in the development of major depression. +3 more findings

  5. 1998-06-01

    The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: We have used linear glycerol velocity and discontinuous sucrose gradient analysis to investigate the distribution and native conformation of PS1 and PS2 during this regulated processing in cultured cells and in brain. +3 more findings

  6. 1998-06-01

    A detergent-insoluble membrane compartment contains A beta in vivo

    ✓ Peer-reviewed Risk genes beyond APOE Nature medicine

    Key finding: To release the amyloidogenic peptide A beta from the Alzheimer amyloid precursor protein (APP), two secretases act sequentially: first, beta-secretase cleaves close to the membrane within the ectodomain and then gamma-secretase cuts within the transmembrane domain. +3 more findings

  7. 1998-06-01

    Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

    ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America

    Key finding: These findings reveal that a departure from the normal ratio of four-repeat to three-repeat tau isoforms leads to the formation of abnormal tau filaments. +1 more finding

Browse the library by subject, with the full score breakdown →