Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 25,926–25,950 of 27,380 studies, newest first · page 1038 of 1096.
August 1998 5
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1998-08-01
What is the amygdala?
47/100 ✓ Peer-reviewed Lewy body dementia Trends in neurosciences
Key finding: Cell groups within it appear to be differentiated parts of the traditional cortex, the claustrum, or the striatum, and these parts belong to four obvious functional systems--accessory olfactory, main olfactory, autonomic and frontotemporal cortical. +4 more findings
Full summary, score breakdown and related studies → Original source
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1998-08-01
Naming in semantic dementia--what matters?
54/100 ✓ Peer-reviewed Digital health tools Neuropsychologia
Key finding: The analyses showed that object familiarity, word frequency and age-of-acquisition predicted naming success for the group and, in most cases, for each individual patient, irrespective of lesion site or overall naming success. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-08-01
Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity
60/100 ✓ Peer-reviewed Genetics JAMA
Key finding: Using parametric methods, no evidence for linkage to the region spanned by the chromosome 12 markers could be detected if familial AD is assumed to arise from the same genetic locus in all 53 families. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-08-01
Alpha-2 macroglobulin is genetically associated with Alzheimer disease
56/100 ✓ Peer-reviewed Genetics Nature genetics
Key finding: Analysis of a deletion in the A2M gene at the 5' splice site of 'exon II' of the bait region (exon 18) revealed that inheritance of the deletion (A2M-2) confers increased risk for AD (Mantel-Haenzel odds ratio=3.56, P=0.001). +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-08-01
Intracerebroventricular administration of quinolinic acid induces a selective decrease of inositol(1,4,5)-trisphosphate receptor in rat brain
30/100 ✓ Peer-reviewed Biomarkers Neurochemistry international
Key finding: In addition, previous results obtained from brains of Alzheimer patients indicated a reduction of IP3-receptor protein correlated to neuronal loss. +1 more finding
Full summary, score breakdown and related studies → Original source
July 1998 13
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1998-07-01
Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
36/100 ✓ Peer-reviewed Treatments Clinical therapeutics
Key finding: Both preclinical studies and studies in human volunteers have shown that rivastigmine induces substantially greater inhibition of AChE in the central nervous system (CNS) compartment than in the periphery (40% inhibition of central AChE compared with 10% inhibition of plasma butylcholinesterase in healthy volunteers). +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-07-01
Demographic and epidemiological determinants of healthcare costs in Netherlands: cost of illness study
40/100 ✓ Peer-reviewed Vascular contributions BMJ (Clinical research ed.)
Key finding: The main determinants of healthcare use in the Netherlands are old age and disabling conditions, particularly mental disability.
Full summary, score breakdown and related studies → Original source
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1998-07-01
Measuring quality of life for patients with terminal illness: the Missoula-VITAS quality of life index
45/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: The MVQOLI demonstrated internal consistency (Cronbach's alpha = 0.77).
Full summary, score breakdown and related studies → Original source
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1998-07-01
Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease
43/100 ✓ Peer-reviewed Risk genes beyond APOE Archives of neurology
Key finding: Previous data from familial AD due to mutations in presenilin 1 and presenilin 2 genes and the amyloid precursor protein suggest that the long form of Abeta peptide, Abeta42, is selectively increased in these circumstances. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-07-01
Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease
50/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: Prior studies report that subjects with neuropathologic evidence of AD and concomitant brain infarcts had poorer cognitive function and higher frequency of dementia than those with AD alone. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-07-01
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
53/100 ✓ Peer-reviewed Lewy body dementia Neuroscience letters
Key finding: These findings provide an unexpected link between multiple system atrophy and Lewy body disorders and establish that alpha-synucleinopathies constitute a major class of human neurodegenerative disorder.
Full summary, score breakdown and related studies → Original source
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1998-07-01
Effect of long term bed rest in men on enzymatic antioxidative defence and lipid peroxidation in erythrocytes
29/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Key finding: However, bed rest results in many alterations which are disadavantageous. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-07-01
The prevalence and 3-year incidence of dementia in older Black and White community residents
48/100 ✓ Peer-reviewed Disparities Journal of clinical epidemiology
Key finding: Prevalence, 3-year incidence, and types of dementia are comparable in Black and White elderly in the Piedmont area of North Carolina. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-07-01
Dementia caregiver burden: a review of the literature and guidelines for assessment and intervention
48/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: Although caregiving is associated with significant psychological and physical morbidity, there are wide individual differences among caregivers in how well they adapt to caregiving demands. +1 more finding
Full summary, score breakdown and related studies → Original source
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1998-07-01
Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities
51/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: The most proximal brain events associated with the clinical expression of dementia are progressive neuronal dysfunction and loss of neurons in specific regions of the brain.
Full summary, score breakdown and related studies → Original source
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1998-07-01
High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype
62/100 ✓ Peer-reviewed Getting a diagnosis Archives of neurology
Key finding: Levels of CSF Abeta42 decrease and levels of CSF tau increase in AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-07-01
Microglial activation in Alzheimer disease: Association with APOE genotype
43/100 ✓ Peer-reviewed Genetics Brain pathology (Zurich, Switzerland)
Key finding: Abeta is bound by apolipoprotein E (APOE) in an isoform-specific manner, and it has been demonstrated that inheritance of the AD susceptibility allele, APOE epsilon4, is associated with increased deposition of Abeta in the cerebral cortex. +2 more findings
Full summary, score breakdown and related studies → Original source
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1998-07-01
Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study
69/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: The APOE genotype is an important determinant of the risk of dementia.
Full summary, score breakdown and related studies → Original source
June 1998 7
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1998-06-01
The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation
36/100 ✓ Peer-reviewed Drug development Brain research. Molecular brain research
Key finding: Prominent neurodegeneration and glial activation occurs around these plaques leading to the hypothesis that Abeta may play a causative role in the neuronal loss and the inflammatory response associated with AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-06-01
Amygdala core nuclei volumes are decreased in recurrent major depression
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuroreport
Key finding: Depressed subjects had bilaterally reduced amygdala core nuclei volumes and no significant differences in total amygdala volumes or in whole brain volumes.
Full summary, score breakdown and related studies → Original source
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1998-06-01
The neuropathology of a chromosome 17-linked autosomal dominant parkinsonism and dementia ("pallido-ponto-nigral degeneration")
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology
Key finding: First, we showed that PPND is characterized by abundant ballooned neurons in neocortical and subcortical regions as well as by tau-rich inclusions in the cytoplasm of neurons and oligodendroglia morphologically similar to those seen in corticobasal degeneration (CBD), but in a distribution pattern resembling progressive supranuclear palsy (PSP). +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-06-01
Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging
53/100 ✓ Peer-reviewed Brain tissue and pathology Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Key finding: Extensive evidence implicates a deficit in serotonergic neurotransmission in the development of major depression. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-06-01
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: We have used linear glycerol velocity and discontinuous sucrose gradient analysis to investigate the distribution and native conformation of PS1 and PS2 during this regulated processing in cultured cells and in brain. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-06-01
A detergent-insoluble membrane compartment contains A beta in vivo
53/100 ✓ Peer-reviewed Risk genes beyond APOE Nature medicine
Key finding: To release the amyloidogenic peptide A beta from the Alzheimer amyloid precursor protein (APP), two secretases act sequentially: first, beta-secretase cleaves close to the membrane within the ectodomain and then gamma-secretase cuts within the transmembrane domain. +3 more findings
Full summary, score breakdown and related studies → Original source
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1998-06-01
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
57/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: These findings reveal that a departure from the normal ratio of four-repeat to three-repeat tau isoforms leads to the formation of abnormal tau filaments. +1 more finding
Full summary, score breakdown and related studies → Original source
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