Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,176–12,200 of 27,380 studies, newest first · page 488 of 1096.
December 2019 25
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2019-12-24
Alzheimer's Disease - Why We Need Early Diagnosis
47/100 ✓ Peer-reviewed Prevention and risk Degenerative neurological and neuromuscular disease
Key finding: It examines how Alzheimer's disease diagnosis rates can be improved, the implications of an early diagnosis for the individual, carer and society, and the importance of risk reduction to prevent or delay progression. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-23
Correlation Between Donepezil and QTc Prolongation and Torsades de Pointes: A Very Rare Phenomenon
39/100 ✓ Peer-reviewed Treatments Cureus
Key finding: Patients demonstrated associated atrioventricular (AV) block or ventricular premature contractions (VPC) or atrial fibrillation (AF) prior to developing torsades de pointes (TdP). +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-12-23
Effect of Clostridium butyricum against Microglia-Mediated Neuroinflammation in Alzheimer's Disease via Regulating Gut Microbiota and Metabolites Butyrate
38/100 ✓ Peer-reviewed Disease mechanisms Molecular nutrition & food research
Key finding: Scope Recent evidences demonstrate that abnormal gut microbiota (GM) might be involved in the pathogenesis of Alzheimer's disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-23
What’s Happening at Home
53/100 ✓ Peer-reviewed Health systems and care delivery Medical Care
Key finding: Overall, 5% of the study population (n=161,801) received 2+ months of HCC visits; of these, 46% also received 2+ HBMC visits (n=73,638) while 54% received only skilled home health (n=88,163 HCC but no HBMC). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-23
A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia
49/100 ✓ Peer-reviewed TREM2 and immune genetics FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Key finding: Microglia, the resident immune cell of the brain, express TREM2, and microglial responses are implicated in dementia pathways. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-23
High Blood Pressure and Cardiovascular Disease
69/100 ✓ Peer-reviewed Prevention and risk Hypertension (Dallas, Tex. : 1979)
Key finding: Fragmented investigation has masked the overall picture for causes of cardiovascular disease (CVD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-20
Is tau in the absence of amyloid on the Alzheimer's continuum?: A study of discordant PET positivity
53/100 ✓ Peer-reviewed Disease mechanisms Brain communications
Key finding: Given that cognitive performance in the A-/T+ group was poorer than in individuals without either pathology, our results suggest that medial temporal lobe tau without cortical amyloid beta may reflect an early stage on the Alzheimer's pathological continuum.
Full summary, score breakdown and related studies → Original source
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2019-12-20
β-Amyloid PET and neuropathology in dementia with Lewy bodies
55/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Lower PiB uptake accurately distinguishes cases with LBD from cases with AD or mixed pathology, correlating with the Thal Aβ phase. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-12-19
Prognostic Awareness, Disease and Palliative Understanding Among Caregivers of Patients With Dementia
55/100 ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care
Key finding: Prognostic discussions between caregivers of PwD and the PwD's physicians may be occurring more often; however, a high percentage of caregivers report a poor understanding about the terminal nature of dementia and the role of PC. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-19
Ethical concerns with the use of intelligent assistive technology: findings from a qualitative study with professional stakeholders
47/100 ✓ Peer-reviewed Digital health tools BMC medical ethics
Key finding: Our findings indicate a general agreement among professional stakeholders on the ethical promises and challenges raised by the use of IATs among older and disabled users. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-18
CSF angiogenin levels in amyotrophic lateral Sclerosis-Frontotemporal dementia spectrum
50/100 ✓ Peer-reviewed Tau biomarkers Amyotrophic lateral sclerosis & frontotemporal degeneration
Key finding: ANG levels didn't differ significantly between cases and controls. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-18
Genetics of Alzheimer's disease: where we are, and where we are going
38/100 ✓ Peer-reviewed Genetics Current opinion in neurobiology
Key finding: Alzheimer's disease (AD) has a very strong genetic component, whose characterization has become an essential part of efforts to understand the pathophysiological processes of the disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-18
Association of brain amyloidosis with the incidence and frequency of neuropsychiatric symptoms in ADNI: a multisite observational cohort study
45/100 ✓ Peer-reviewed Long-term cohort studies BMJ open
Key finding: 275 cognitively normal controls (NC), 100 subjective memory complaint (SMC), 559 mild cognitive impairment (MCI) and 143 Alzheimer's disease dementia subjects from the Alzheimer's Disease Neuroimaging Initiative received ( 18 F)-florbetapir positron emission tomography (PET) scans. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-18
A Deep Learning Approach for Automated Diagnosis and Multi-Class Classification of Alzheimer's Disease Stages Using Resting-State fMRI and Residual Neural Networks
64/100 ✓ Peer-reviewed Long-term cohort studies Journal of medical systems
Key finding: Although, research on AD has increased in recent years, however, the complexity associated with brain structure and functions makes the early diagnosis of this disease a challenging task. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-18
A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
58/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia (New York, N. Y.)
Key finding: This study showed that plasma metabolites have the potential to match the AUC of well-established AD CSF biomarkers in a relatively small cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-17
Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease
57/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: The participants with PD had significantly weaker FC between the vermis and peristriate visual association cortex compared to controls, and the strength of this FC correlated with visuospatial function and global cognition. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-17
Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health
41/100 ✓ Peer-reviewed Disease mechanisms Biomolecules
Key finding: Cooking at high temperature results in various food products having high levels of AGEs. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-17
Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice
39/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy
Key finding: Alzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-17
Effect of fresh pomegranate juice on the level of melatonin, insulin, and fasting serum glucose in healthy individuals and people with impaired fasting glucose
42/100 ✓ Peer-reviewed Treatments Food science & nutrition
Key finding: People with IFG, but not healthy individuals, had significant antihyperglycemic response ( p p = .4287). +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-17
Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects
47/100 ✓ Peer-reviewed Biomarkers Neuro-degenerative diseases
Key finding: The progressive decrement of neuropsychological performance is associated with HVL long before the emergence of clinically overt symptoms. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-16
Survival time tool to guide care planning in people with dementia
64/100 ✓ Peer-reviewed End-of-life care Neurology
Key finding: Three-year survival after dementia diagnosis can be predicted with good accuracy.
Full summary, score breakdown and related studies → Original source
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2019-12-16
Effects of Transcranial Direct Current Stimulation Paired With Cognitive Training on Functional Connectivity of the Working Memory Network in Older Adults
48/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience
Key finding: These results suggest pairing tDCS with cognitive training enhances functional connectivity and working memory performance in older adults, and thus may hold promise as a method for remediating age-related cognitive decline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-16
A multi-model deep convolutional neural network for automatic hippocampus segmentation and classification in Alzheimer's disease
56/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage
Key finding: Additionally, the extraction of these features is independent of the classification model, which could result in sub-optimal performance. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-12-16
Adaptation of the Clinical Dementia Rating Scale for adults with Down syndrome
39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurodevelopmental disorders
Key finding: The modified questionnaire and interview instruments capture a range of impairment in DS adults, including subthreshold symptomatology, and the instruments provide complementary information relevant to the ascertainment of dementia in DS. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-12-16
Benchmarking machine learning models for late-onset alzheimer's disease prediction from genomic data
43/100 ✓ Peer-reviewed Digital health tools BMC bioinformatics
Key finding: Machine learning models are promising alternatives for estimating the genetic risk of LOAD. +2 more findings
Full summary, score breakdown and related studies → Original source
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