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Neurovascular and Cognitive Dysfunction in Hypertension
Iadecola C, Gottesman RF.. Circulation research, 2019-03-01
Topic: Risk, prevention and care in population studies
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long known to be associated with dementia caused by vascular factors, hypertension has more recently been linked also to Alzheimer disease-the major cause of dementia in older people. Thus, although midlife hypertension is a risk factor for late-life dementia, hypertension may also promote the neurodegenerative pathology underlying Alzheimer disease. The mechanistic bases of these harmful effects remain to be established. Hypertension is well known to alter in the structure and function of cerebral blood vessels, but how these cerebrovascular effects lead to cognitive impairment and promote Alzheimer disease pathology is not well understood. Furthermore, critical questions also concern whether treatment of hypertension prevents cognitive impairment, the blood pressure threshold for treatment, and the antihypertensive agents to be used. Recent advances in neurovascular biology, epidemiology, brain imaging, and biomarker development have started to provide new insights into these critical issues. In this review, we will examine the progress made to date, and, after a critical evaluation of the evidence, we will highlight questions still outstanding and seek to provide a path forward for future studies.
Key findings
- Long known to be associated with dementia caused by vascular factors, hypertension has more recently been linked also to Alzheimer disease-the major cause of dementia in older people.
Why it matters
This review states that hypertension is a leading cause of age-related cognitive impairment and has been linked to Alzheimer disease, and that midlife hypertension is a risk factor for late-life dementia. It notes that whether treatment of hypertension prevents cognitive impairment remains a critical open question.
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Study details
- Evidence strengthLow
How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Circulation research) |
| Journal's citation record | 4 / 4 | Circulation Research: journal h-index 507 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 501 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 55.7 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 5 / 6 | Cited 39.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 4 / 4 | Cited 201 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Rebecca F. Gottesman: h-index 92 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Johns Hopkins University: institution h-index 2,306 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30920929) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 54 / 100 | — |
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Read the original
- DOI: 10.1161/circresaha.118.313260
- PubMed: 30920929
- Original source →
- Free full text: Circulation Research →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Iadecola, C., & Gottesman, R. F. (2019). Neurovascular and Cognitive Dysfunction in Hypertension. Circulation research. https://doi.org/10.1161/circresaha.118.313260
Vancouver
Iadecola C, Gottesman RF. Neurovascular and Cognitive Dysfunction in Hypertension. Circulation research. 2019. doi:10.1161/circresaha.118.313260. PMID: 30920929.
BibTeX
@article{iadecola2019-30920929,
author = {Iadecola, C. and Gottesman, R. F.},
title = {{Neurovascular and Cognitive Dysfunction in Hypertension}},
journal = {Circulation research},
year = {2019},
doi = {10.1161/circresaha.118.313260},
pmid = {30920929},
url = {https://doi.org/10.1161/circresaha.118.313260}
}
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