Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,826–11,850 of 27,380 studies, newest first · page 474 of 1096.
March 2020 25
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2020-03-11
Cryo-temperature effects on membrane protein structure and dynamics
39/100 ✓ Peer-reviewed Biomarkers Physical chemistry chemical physics : PCCP
Key finding: The hot state features an unwound C83-substrate with 10-14 α-helix residues (6IYC: 11) in equilibrium with an intact state with 16 helix residues not previously reported. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-11
Efficacy of a Web App for Cognitive Training (MeMo) Regarding Cognitive and Behavioral Performance in People With Neurocognitive Disorders: Randomized Controlled Trial
76/100 ✓ Peer-reviewed Prevention trials Journal of medical Internet research
Key finding: This study indicates that the cognitive and behavioral efficacies of MeMo, a Web-based training app, can be observed only with regular use of the app. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-11
The Role of Selected Bioactive Compounds in the Prevention of Alzheimer's Disease
41/100 ✓ Peer-reviewed Prevention trials Antioxidants (Basel, Switzerland)
Key finding: However, many studies have suggested that modification of lifestyle factors, such as the introduction of an appropriate diet, can delay or prevent the onset of this disorder. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-03-11
Macrophage subsets in atherosclerosis as defined by single-cell technologies
51/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of pathology
Key finding: Many studies have shone light on the different phenotypes and functions that macrophages can acquire upon exposure to local cues. +3 more findings
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2020-03-10
DNA Methylation Biomarkers in Aging and Age-Related Diseases
41/100 ✓ Peer-reviewed Genetics Frontiers in genetics
Key finding: There is growing evidence suggesting epigenetic age acceleration to be strongly linked to common diseases or occurring in response to various environmental factors. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-10
Acute increases in brain-derived neurotrophic factor in plasma following physical exercise relates to subsequent learning in older adults
76/100 ✓ Peer-reviewed Prevention trials Scientific reports
Key finding: Brain-derived neurotrophic factor (BDNF) is essential for experience-dependent plasticity and increases following physical exercise, suggesting that physical exercise may facilitate subsequent learning. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-03-10
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
54/100 ✓ Peer-reviewed TREM2 and immune genetics EMBO molecular medicine
Key finding: To enhance TREM2 activity, we sought to selectively increase the full-length protein on the cell surface via reducing its proteolytic shedding by A Disintegrin And Metalloproteinase (i.e., α-secretase) 10/17. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-10
2020 Alzheimer's disease facts and figures
58/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society. +1 more finding
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2020-03-09
Sex differences in the response to oxidative and proteolytic stress
39/100 ✓ Peer-reviewed Disease mechanisms Redox biology
Key finding: Sex differences in diseases involving oxidative and proteolytic stress are common, including greater ischemic heart disease, Parkinson disease and stroke in men, and greater Alzheimer disease in women. +3 more findings
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2020-03-09
Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders
38/100 ✓ Peer-reviewed Risk factors Pharmacology & therapeutics
Key finding: Recent extensive evidence indicates that air pollution, in addition to causing respiratory and cardiovascular diseases, may also negatively affect the brain and contribute to central nervous system diseases. +3 more findings
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2020-03-06
Impact of urban environmental exposures on cognitive performance and brain structure of healthy individuals at risk for Alzheimer's dementia
62/100 ✓ Peer-reviewed Risk factors Environment international
Key finding: In cognitively unimpaired adults with increased risk for AD, increased exposure to air pollution was suggested to be associated with greater global atrophy and reduced volume and thickness in specific brain areas known to be affected in AD, thus suggesting a potential link between environmental exposures and cerebral vulnerability to AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-05
Shared Causal Paths underlying Alzheimer's dementia and Type 2 Diabetes
48/100 ✓ Peer-reviewed Genetics Scientific reports
Key finding: Although Alzheimer's disease (AD) is a central nervous system disease and type 2 diabetes MELLITUS (T2DM) is a metabolic disorder, an increasing number of genetic epidemiological studies show clear link between AD and T2DM. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-05
Biomarker potential of brain-secreted extracellular vesicles in blood in Alzheimer's disease
41/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Blood-isolated BEVs have emerged as a novel player in the study of AD, with enormous potential as a diagnostic, evaluation of therapeutics, and treatment tool.
Full summary, score breakdown and related studies → Original source
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2020-03-05
Efficacy of multidomain interventions to improve physical frailty, depression and cognition: data from cluster-randomized controlled trials
64/100 ✓ Peer-reviewed Prevention trials Journal of cachexia, sarcopenia and muscle
Key finding: Efficacy Study participants (n = 1082, 40 clusters) were 75.1 ± 6.3 years old, 68.7% women, and 64.7% prefrail/frail; analytic clusters: 19 intervention (410/549 completed) vs. 21 control (375/533 completed). +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-03-05
Sepsis-Associated Encephalopathy: From Delirium to Dementia?
47/100 ✓ Peer-reviewed Caregiving Journal of clinical medicine
Key finding: The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality.
Full summary, score breakdown and related studies → Original source
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2020-03-04
Hospice Staff Perspectives on Caring for People with Dementia: A Multisite, Multistakeholder Study
39/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: Four themes regarding caring for PWD in hospice. +4 more findings
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2020-03-04
Pesticides, cognitive functions and dementia: A review
38/100 ✓ Peer-reviewed Risk factors Toxicology letters
Key finding: Previous studies that evaluated the effect of low dose chronic exposure to mixtures of pesticides and other chemicals intending to simulate real life exposure scenarios showed that hormetic neurobehavioral effects can appear after mixture exposure at doses considered safe for individual compounds and these effects can be exacerbated by a coexistence with specific conditions such as vitamin deficiency. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-03-04
Liraglutide Protects Against Brain Amyloid-β 1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation
41/100 ✓ Peer-reviewed Drug development International journal of molecular sciences
Key finding: However, evidence suggests that effective anti-T2D drugs, such as the GLP-1 mimetic and neuroprotector liraglutide, can be also efficient against AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-03-04
Anatomy and function of the fornix in the context of its potential as a therapeutic target
41/100 ✓ Peer-reviewed Clinical safety Journal of neurology, neurosurgery, and psychiatry
Key finding: As the most prevalent cause of dementia, Alzheimer's disease (AD) dramatically impairs the quality of life of patients and imposes a significant societal burden on the healthcare system. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-03
Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity
41/100 ✓ Peer-reviewed Drug development International Journal of Molecular Sciences
Key finding: Neuronal insulin resistance is a significant feature of Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-02
Apolipoprotein E regulates the maturation of injury-induced adult-born hippocampal neurons following traumatic brain injury
39/100 ✓ Peer-reviewed Genetics PloS one
Key finding: It has previously been established that Apolipoprotein E (ApoE) plays a regulatory role in adult hippocampal neurogenesis, which is of particular interest as the presence of the human ApoE isoform ApoE4 leads to significant risk for the development of late-onset Alzheimer's disease, where impaired neurogenesis has been linked with disease progression. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-03-02
Association Between Hormone-Modulating Breast Cancer Therapies and Incidence of Neurodegenerative Outcomes for Women With Breast Cancer
64/100 ✓ Peer-reviewed Digital health tools JAMA network open
Key finding: Among patients with breast cancer, tamoxifen and steroidal aromatase inhibitors were associated with a decrease in the number who received a diagnosis of NDD, specifically Alzheimer disease and dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-02
Increasing Complexity of New Nursing Home Residents in Ontario, Canada: A Serial Cross-Sectional Study
48/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society
Key finding: Admission trends show that new residents were older and had greater multimorbidity and limitations in physical functioning over time.
Full summary, score breakdown and related studies → Original source
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2020-03-02
Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with mild cognitive impairment
71/100 ✓ Peer-reviewed Mild cognitive impairment The Cochrane database of systematic reviews
Key finding: In clinical samples, people with amnestic MCI are at high risk of developing Alzheimer's disease dementia, with annual rates of progression from MCI to Alzheimer's disease estimated at approximately 10% to 15% compared with the base incidence rates of Alzheimer's disease dementia of 1% to 2% per year. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-02
Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration
64/100 ✓ Peer-reviewed Lewy body dementia Nature medicine
Key finding: Plasma pTau181 concentrations were increased by 3.5-fold in AD compared to controls and differentiated AD from both clinically diagnosed (receiver operating characteristic area under the curve of 0.894) and autopsy-confirmed frontotemporal lobar degeneration (area under the curve of 0.878). +1 more finding
Full summary, score breakdown and related studies → Original source
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