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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 15,576–15,600 of 27,380 studies, newest first · page 624 of 1096.

December 2016 25

  1. 2016-12-18

    Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

    ✓ Peer-reviewed Genetics Brain, behavior, and immunity

    Key finding: Research reporting inflammatory changes in post mortem brain tissue of individuals with AD and GWAS data have convincingly demonstrated that neuroinflammation is likely to be a key driver of the disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2016-12-18

    Rey's Auditory Verbal Learning Test scores can be predicted from whole brain MRI in Alzheimer's disease

    ✓ Peer-reviewed Digital health tools NeuroImage. Clinical

    Key finding: Several studies have shown that an impairment in RAVLT scores reflect well the underlying pathology caused by Alzheimer's disease (AD), thus making RAVLT an effective early marker to detect AD in persons with memory complaints. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2016-12-16

    Clusterin as a therapeutic target

    ✓ Peer-reviewed Risk genes beyond APOE Expert opinion on therapeutic targets

    Key finding: Clusterin (CLU) is a stress-activated, ATP-independent molecular chaperone, normally secreted from cells, that is up-regulated in Alzheimer disease and in many cancers. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2016-12-15

    A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease

    ✓ Peer-reviewed Genetics Cell systems

    Key finding: Here, we report proteomic analyses of 129 human cortical tissues to define changes associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD). +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2016-12-15

    Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

    ✓ Peer-reviewed Prevention and risk Stroke

    Key finding: Two decades of epidemiological research shows that silent cerebrovascular disease is common and is associated with future risk for stroke and dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2016-12-13

    Earlier Goals of Care Discussions in Hospitalized Terminally Ill Patients and the Quality of End-of-Life Care: A Retrospective Study

    ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

    Key finding: Later GOCDs were associated with greater risk of aggressive interventions and death as an inpatient and greater odds of ICU admission. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2016-12-13

    A systematic review of the psychobiological burden of informal caregiving for patients with dementia: Focus on cognitive and biological markers of chronic stress

    ✓ Peer-reviewed Caregiving Neuroscience and biobehavioral reviews

    Key finding: As the physiological impact of chronic stress is difficult to study in humans, naturalistic stressors are invaluable sources of information in this area. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2016-12-12

    Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

    ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica communications

    Key finding: A recent phase III trial of [18F]flutemetamol positron emission tomography (PET) imaging in 106 end-of-life subjects demonstrated the ability to identify fibrillar β-amyloid by comparing in vivo PET to post-mortem histopathology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2016-12-12

    Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis

    ✓ Peer-reviewed Biomarkers Biomarker research

    Key finding: Differential correlation analysis, a bioinformatics tool to elucidate complicated and interdependent biological systems behind diseases, detects effective MCI markers that cannot be found by single molecule analysis such as t-test. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2016-12-12

    Associations of hippocampal subfields in the progression of cognitive decline related to Parkinson's disease

    ✓ Peer-reviewed Mild cognitive impairment NeuroImage. Clinical

    Key finding: The findings from this study add to the anatomical knowledge of hippocampal subregions in PD, allowing us to understand the unique functional contribution of each subfield. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2016-12-11

    AVP-786 for the treatment of agitation in dementia of the Alzheimer's type

    ✓ Peer-reviewed Clinical trials Expert opinion on investigational drugs

    Key finding: This program is expected to start generating results in July 2018.

    Full summary, score breakdown and related studies → Original source

  12. 2016-12-10

    Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial

    ✓ Peer-reviewed Caregiving The Lancet. Neurology

    Key finding: We randomly assigned patients with a computer-generated sequence in a 4:1 ratio overall to receive AADvac1 or placebo.

    Full summary, score breakdown and related studies → Original source

  13. 2016-12-09

    Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

    Key finding: Patients with all biomarkers positive for AD (N = 145) had the highest hazard for progression to dementia due to AD, whilst patients with no positive biomarkers (N = 111) had the lowest. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2016-12-08

    Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

    ✓ Peer-reviewed Genetics Molecular neurodegeneration

    Key finding: We show that the glymphatic fluid transporting system contributes to the delivery of choroid plexus/CSF-derived human apoE to neurons. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2016-12-08

    Cognitive Aging and the Hippocampus in Older Adults

    ✓ Peer-reviewed Cognitive tests and assessment Frontiers in aging neuroscience

    Key finding: While age-related decline in hippocampal volume is well documented, most of our knowledge about hippocampal structure-function relationships was discovered in the context of neurological and neurodegenerative diseases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2016-12-08

    A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

    ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: A variant within a DNase hypersensitive site 5' of TREM2, rs9357347-C, associates with reduced AD risk and increased TREML1 and TREM2 levels (uncorrected P = 6.3 × 10 -3 and 4.6 × 10 -2 , respectively). +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2016-12-07

    Validation of the V66.7 Code for Palliative Care Consultation in a Single Academic Medical Center

    ✓ Peer-reviewed End-of-life care Journal of palliative medicine

    Key finding: In a single center, the ICD-9 code V66.7 had poor sensitivity and high specificity for identifying hospitalized patients who received a palliative care consultation.

    Full summary, score breakdown and related studies → Original source

  18. 2016-12-07

    Differential diagnosis of mild cognitive impairment and Alzheimer's disease using structural MRI cortical thickness, hippocampal shape, hippocampal texture, and volumetry

    ✓ Peer-reviewed Long-term cohort studies NeuroImage. Clinical

    Key finding: The method was developed, trained, and evaluated using two publicly available reference datasets: a standardized dataset from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the imaging arm of the Australian Imaging Biomarkers and Lifestyle flagship study of ageing (AIBL). +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2016-12-06

    Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases

    ✓ Peer-reviewed TREM2 and immune genetics The International journal of neuroscience

    Key finding: Recent laboratory and gene sequencing data suggest that variations in receptors called the "triggering-receptors-expressed-on-myeloid-cells" (TREMs) are implicated in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and frontotemporal lobar degeneration. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2016-12-05

    Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7)

    ✓ Peer-reviewed Brain scans and imaging Genes

    Key finding: Highly-specific small ssRNAs, such as the ~23 nucleotide (nt) Homo sapien microRNA-7 (hsa-miRNA-7; chr 9q21.32), are not only abundant in the human limbic system but are, in addition, associated with a ~1400 nt circRNA for miRNA-7 (ciRS-7) in the same anatomical region. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2016-12-05

    Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

    ✓ Peer-reviewed Biomarkers Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Notably, 10% of these mutations result in decreased Aβ42/Aβ40 ratios. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2016-12-05

    An update on semantic dementia: genetics, imaging, and pathology

    ✓ Peer-reviewed Clinical safety Alzheimer's research & therapy

    Key finding: Functional magnetic resonance imaging (fMRI) studies have revealed widespread changes in connectivity, implicating the anterior temporal regions in semantic deficits in SD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2016-12-05

    The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: ADNI-3 will aim to inform AD treatment trials and facilitate development of AD disease-modifying treatments. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2016-12-04

    Pioglitazone for the treatment of Alzheimer's disease

    ✓ Peer-reviewed Clinical trials Expert opinion on investigational drugs

    Key finding: Expert opinion: A Phase II study in AD, and its previous indication for diabetes, showed that Pioglitazone is safe and well tolerated. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2016-12-02

    The application of retinal fundus camera imaging in dementia: A systematic review

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: Ten studies assessing retinal properties in dementia were included. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →