Newest studies

Cerebral Small Vessel Disease and Risk of Cardiovascular Events and All-Cause Mortality: The Framingham Heart Study

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

Key finding: Increasing CSVD burden was associated with higher incidence rates of the composite outcome. +3 more findings

• Risk Factors
• Brain Scans
• Other Dementias

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Adult-onset hippocampal α7 nicotinic acetylcholine receptor loss rapidly drives Alzheimer-like neuropathology in mice

34/100 ✓ Peer-reviewed Genetics Frontiers in Pharmacology

Key finding: The knockdown of α7 nAChR in the hippocampus of adult mice rapidly induced cognitive deficits, impairments in learning and memory, and led to the increase of amyloid-β levels, Tau protein aggregation, neuronal damage, and the activation of astrocytes and microglia. +4 more findings

• Brain Biology

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Instrumental activities of daily living in older adults with epilepsy: A cross‐sectional and longitudinal multicenter study

52/100 ✓ Peer-reviewed Risk factors Epilepsia

Key finding: Of 57 participants (mean age ± SD = 66.6 ± 7.2 years; female = 52.6%), 38.6% (n = 22) had MCI-level functional impairment and 17.5% (n = 10) had dementia-level functional impairment. +4 more findings

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Prion disease mimicking rapidly progressive Alzheimer disease: case series and systematic review

52/100 ✓ Peer-reviewed Tau biomarkers Journal of neurology

Key finding: Prion disease and Alzheimer disease (AD) are common causes of rapidly progressive dementia (RPD). +3 more findings

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Face Processing Impairments in Dementia Syndromes: A Systematic Review

16/100 ⚠ Preprint — not yet peer-reviewed Lewy body dementia PsyArXiv

Key finding: Eligible studies were primary experimental studies published in English or French that assessed perceptual, memory, or semantic face- or person-processing in individuals with dementia compared with healthy controls. +4 more findings

• Other Dementias

Scored 60 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Data-driven subtyping of Alzheimer's emergency presentations using unsupervised machine learning

41/100 ✓ Peer-reviewed Risk factors IBRO neuroscience reports

Key finding: Among adults aged ≥ 75 years, clusters more frequently included cardiorenal disease, urinary tract infection, metabolic encephalopathy, respiratory failure, do-not-resuscitate status, and palliative care. +4 more findings

• Digital Tools

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Fear of Dementia among Middle-Aged and Older Adults in China: Lived Experiences, Coping, and Support Needs

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology medRxiv (preprint)

Key finding: Preferred interventions were accessible, low-burden, and professionally guided. +4 more findings

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Unlocking Sensitive Data with SPHERE in the Age of AI

16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies bioRxiv

Key finding: Analyses of the twin reproduce genome- and proteome-wide results at UK Biobank scale and recover the findings of landmark studies across three independent cohorts and consortia.

• Digital Tools

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Ancestry-specific effects of APOE on Alzheimer Disease Endophenotypes

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv (preprint)

Key finding: RESULTSAPOE {varepsilon}4+ was associated with higher pTau217 and pTau181, lower A{beta}42/A{beta}40, and worse global cognition (CDR-SB), significant within ancestry groups after FDR correction.

• Biomarkers
• Genetics

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Alzheimer disease risk estimates lose clinical calibration across study phases despite useful patient ranking

16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies Research Square

Key finding: The results extend calibration-drift research to Alzheimer disease and support revalidation of probability scales when recruitment, disease mix, or measurement practice changes.

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Digital and Health Literacy Are Associated with Health-Related Quality of Life Across Cognitive Impairment Stages in Older Adults

16/100 ⚠ Preprint — not yet peer-reviewed How common it is Research Square

Key finding: Digital literacy is a meaningful predictor of HRQoL in older adults with intact or mildly impaired cognition, underscoring its potential as an intervention target in digital health strategies. +4 more findings

• Digital Tools

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Repetitive negative thinking moderates the association between self-referential thoughts and cognition amongst older adults: a natural speech analysis approach

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools Research Square

Key finding: Natural language processing has been examined as a possible biomarker for cognitive decline and dementia, but it has also been associated with components of well-being and psychological distress. +2 more findings

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Prevalence and influencing factors of cognitive frailty among elderly hypertensive rural community residents of Inner Mongolia, China：A Cross-Sectional Survey

16/100 ⚠ Preprint — not yet peer-reviewed Disparities Research Square

Key finding: This study reports the prevalence of CF among elderly hypertensive residents of a community in Inner Mongolia. +4 more findings

• Health Equity
• Diagnosis
• Risk Factors

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Dyadic self- and informant-reported cognitive concern and subsequent MCI/AD diagnosis in ADNI: an exploratory prognostic modelling study

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving Research Square

Key finding: Adding the dyadic mean yielded an estimated ΔC of 0.010 (95% CI -0.003 to 0.024). +3 more findings

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Transthyretin Contributes to Hippocampal Blood-Brain Barrier Recovery Following Intestinal Inflammation, with Reduced Expression in Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

Key finding: These findings identify TTR as a contributor of adaptive neurovascular homeostasis during gut-derived neuroinflammation. +2 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Modifiable Risk Factors for Dementia across the Europe: regional comparative studyusing SHARE data

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

Key finding: Our findings reveal marked geographic variation in dementia risk factors, highlighting the need for region-specific prevention strategies. +3 more findings

• Risk Factors
• Prevention

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Comparative Value of Cognitive and Functional Assessments for Predicting 24-Month Progression from Mild Cognitive Impairment to Alzheimer's Disease: An ADNI Cohort Study

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: Episodic memory showed the highest predictive performance (AUC = 0.915), followed by the Functional Activities Questionnaire (AUC = 0.913). +4 more findings

• Early Stage
• Genetics

Scored 28 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Smooth Curves, Similar Conclusions? Comparing Linear Regression and GAMLSS Neuropsychological Norms

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

Key finding: However, downstream clinical differences were modest in this setting, suggesting that well-calibrated LR norms may remain robust for clinical classification.

• Biomarkers

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Secondary causes among adult patients presenting with first-episode psychosis to acute medical settings in Hong Kong: A 10-Year retrospective study

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv (preprint)

Key finding: Substance use is the most common secondary cause found (n=11, 2.9% of all FEPs) overall. +1 more finding

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Systematic Modality Ablation of Multimodal Machine Learning for Predicting 24-Month Progression from Mild Cognitive Impairment to Alzheimer's Disease

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: Excluding cognitive assessments produced the largest reduction (AUC=0.883, P<0.001 vs. multimodal), the only comparison to remain significant after correction. +2 more findings

• Genetics
• Early Stage
• Biomarkers

Scored 28 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Integrative multi-omics QTL colocalization maps regulatory architecture in aging human brain

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv (preprint)

Key finding: ColocBoost employs a specialized gradient boosting framework that can adaptively couple colocalized traits while performing causal variant selection, thereby enhancing the detection of weaker shared signals compared to existing pairwise and multi-trait colocalization methods. +1 more finding

• Genetics
• Policy

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Cell type- and tau lesion-specific accumulation of phospho-Ser65 ubiquitin in primary tauopathies

32/100 ✓ Peer-reviewed Disease mechanisms Acta Neuropathologica Communications

Key finding: Significant deposition of pS65-Ub has been previously demonstrated in autopsy brains from patients with Lewy body disease, Alzheimer disease, and MAPT mutation-associated frontotemporal lobar degeneration, where increased pS65-Ub signal was particularly strongly associated with early neuronal tau pathology. +3 more findings

• Brain Biology

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Alismatis Rhizoma prevents AβO-induced neuronal cell death and synaptic loss in Alzheimer’s disease models

32/100 ✓ Peer-reviewed Disease mechanisms Frontiers in Pharmacology

Key finding: In AβO-injected mice, AR, particularly at 200 mg/kg, attenuated memory deficits, reduced hippocampal neuronal degeneration, preserved synaptic protein immunoreactivity and increased markers of hippocampal cell proliferation and immature neurons. +4 more findings

• Brain Biology

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GLP-1 Receptor Agonists Beyond Glycemic Control: Clinical Implications in Neurodegenerative Disease and Substance Use Disorders

34/100 ✓ Peer-reviewed Drug development Journal of Community Hospital Internal Medicine Perspectives

Key finding: For clinicians, their role remains within approved cardiometabolic indications, with emerging relevance in comorbidity recognition, safety monitoring, and consideration of clinical trial referral.

• Clinical Trials
• Treatments

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Proteomic signatures of APOE ε4 across human tissues and cell types in Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies bioRxiv

Key finding: Carriage was also associated with greater neuropathological burden, reflected in higher Braak stages and CERAD scores. +2 more findings

• Genetics
• Brain Biology

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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