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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,551–10,575 of 27,380 studies, newest first · page 423 of 1096.

February 2021 25

  1. 2021-02-11

    Cognitively normal APOE ε4 carriers have specific elevation of CSF SNAP-25

    ✓ Peer-reviewed Biomarkers Neurobiology of aging

    Key finding: CSF SNAP-25, not CSF Ng, was specifically elevated in APOE ε4 carriers versus noncarriers (5.95 ± 1.72 pg/mL, 4.44 ± 1.40 pg/mL, p < 0.0001), even after adjusting for age, sex, years of education, and amyloid status (p < 0.0001). +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2021-02-10

    Amyloid PET Imaging in Self-Identified Non-Hispanic Black Participants of the Anti-Amyloid in Asymptomatic Alzheimer's Disease (A4) Study

    ✓ Peer-reviewed Treatments Neurology

    Key finding: Reduced amyloid was observed in self-identified NHB participants who passed initial eligibility criteria for the A4 study. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2021-02-10

    Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: Current Evidence and Future Perspectives

    ✓ Peer-reviewed Disease mechanisms Brain sciences

    Key finding: Over the last two decades, there has been significant growth in the investigation of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  4. 2021-02-09

    Genetic predictors of participation in optional components of UK Biobank

    ✓ Peer-reviewed Genetics Nature Communications

    Key finding: We used GWAS to identify genetic variants associated with participation, MR to estimate effects of phenotypes on participation, and genetic correlations to compare participation bias across different studies. 32 variants were associated with participation in one of the optional components ( P <6×10 -9 ), including loci with known links to intelligence and Alzheimer’s disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-02-09

    Selective coactivation of α7- and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction

    ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry

    Key finding: Here, we showed that Aβ associated with α7- and α4β2-nAChRs but not α3β4-nAChRs. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-02-09

    GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease

    ✓ Peer-reviewed Digital health tools Seminars in cell & developmental biology

    Key finding: Well-established animal models have shown that GABA plays a central role in regulating and synchronizing neuronal signaling in the hippocampus, a brain area critical for episodic memory that undergoes early and significant morphologic and functional changes in the course of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-02-09

    Fine Particle Exposure and Clinical Aggravation in Neurodegenerative Diseases in New York State

    ✓ Peer-reviewed Risk factors Environmental health perspectives

    Key finding: Evidence suggests that air pollution may contribute to aggravation of neurodegeneration, but studies have been limited. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-02-09

    Do ecological factors influence the clinical presentation of amyotrophic lateral sclerosis?

    ✓ Peer-reviewed Risk factors Journal of Neurology Neurosurgery & Psychiatry

    Key finding: More recently, however, it has become clear that ALS is pleiotropic and its phenotype could vary depending on several factors: age of onset, prevalent damage to the upper (UMN) or the lower motor neuron, body region mostly affected, progression rate and presence of non-motor symptoms, the most frequent being cognitive impairment.1 As a consequence, different phenotypes have been described.2 It remains unclear whether these presentations should be considered as distinct clinical entities or as variants of the same disease.3 More importantly, we do not know if different aetiologies justify this variability.3 Despite these uncertainties, we approach clinical trials by administering the same treatment to all patients with ALS.3 Spatial epidemiology could give some clues on aetiology by identifying clusters and subsequently seeking for causative genetic or environmental factors. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-02-08

    Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation

    ✓ Peer-reviewed Genetics Glia

    Key finding: APOE4 microglia showed higher baseline secretion of TNFα compared to APOE2 and APOE3 microglia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2021-02-08

    The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy

    ✓ Peer-reviewed Disease mechanisms Ageing research reviews

    Key finding: In addition, recent evidence has shown that RV mediates epigenetic changes involved in ageing and the function of the CNS that persists across generations. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2021-02-08

    Assessment of the DTI-ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia

    ✓ Peer-reviewed Cognitive tests and assessment Journal of neuroimaging : official journal of the American Society of Neuroimaging

    Key finding: Recently, there has been growing interest in the glymphatic system (the functional waste clearance pathway for the central nervous system and its role in flushing solutes (such as amyloid ß and tau), metabolic, and other cellular waste products in the brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-02-06

    GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease

    ✓ Peer-reviewed Drug development Molecular metabolism

    Key finding: We revealed GLP-1's capacity to regulate astrocytic glycolysis, providing mechanistic insight into one of its neuroprotective roles in AD and support for the feasibility of energy regulation treatments for AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-02-06

    Is personality associated with dementia risk? A meta-analytic investigation

    ✓ Peer-reviewed Disparities Ageing research reviews

    Key finding: Higher neuroticism (HR = 1.24, 95% CI [1.17, 1.31]) and lower conscientiousness (HR = 0.77, 95% CI [0.73, 0.81]) were associated with increased dementia risk, even after accounting for covariates such as depressive symptoms. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-02-05

    Tau and Amyloid Relationships with Resting-state Functional Connectivity in Atypical Alzheimer's Disease

    ✓ Peer-reviewed Brain scans and imaging Cerebral cortex (New York, N.Y. : 1991)

    Key finding: The regional rate of tau accumulation was associated with tau levels in functionally connected regions, in support of tau accumulation in a functional network.

    Full summary, score breakdown and related studies → Original source

  15. 2021-02-05

    Continuous gait monitoring discriminates community-dwelling mild Alzheimer's disease from cognitively normal controls

    ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (New York, N. Y.)

    Key finding: Variability in step velocity and cadence had the highest predictive utility in identifying individuals with mild AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-02-05

    Multimodal deep learning models for early detection of Alzheimer's disease stage

    ✓ Peer-reviewed Digital health tools Scientific reports

    Key finding: We use stacked denoising auto-encoders to extract features from clinical and genetic data, and use 3D-convolutional neural networks (CNNs) for imaging data. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-02-05

    In vivo tau pathology is associated with synaptic loss and altered synaptic function

    ✓ Peer-reviewed Disease mechanisms Alzheimer's research & therapy

    Key finding: These results indicate that in Alzheimer's disease, tau pathology is closely associated with reduced synaptic density and synaptic dysfunction. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-02-05

    Resting state EEG biomarkers of cognitive decline associated with Alzheimer's disease and mild cognitive impairment

    ✓ Peer-reviewed Mild cognitive impairment PloS one

    Key finding: Compared to age matched controls, in the AD group, we found increases in both spectral power and coherence at the slower frequencies (Delta, Theta). +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-02-05

    Can Use of Digital Technologies by People with Dementia Improve Self-Management and Social Participation? A Systematic Review of Effect Studies

    ✓ Peer-reviewed Digital health tools Journal of clinical medicine

    Key finding: Of 1394 records identified, nine met the inclusion criteria: two were deemed to be of poor methodological quality, six of fair quality, and one of good quality. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-02-04

    TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer's Disease: Lessons Learned from Transcriptomics

    ✓ Peer-reviewed TREM2 and immune genetics Cells

    Key finding: Missense mutations in human TREM2 are determined as genetic risk factors associated with the development of sporadic AD.

    Full summary, score breakdown and related studies → Original source

  21. 2021-02-04

    Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease

    ✓ Peer-reviewed Disease mechanisms Frontiers in cell and developmental biology

    Key finding: Increasing evidence suggests that gut dysbiosis plays vital roles in a variety of gut-brain disorders, such as Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-02-04

    Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia

    ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience

    Key finding: Pursuit error was significantly correlated with cognitive measures of constructional praxis and executive function and metabolism in right posterior middle temporal gyrus. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2021-02-04

    Trends in predominant causes of death in individuals with and without diabetes in England from 2001 to 2018: an epidemiological analysis of linked primary care records

    ✓ Peer-reviewed Caregiving The lancet. Diabetes & endocrinology

    Key finding: We estimated how all-cause mortality and cause-specific mortality in people with diabetes have changed over time, how the composition of the mortality burden has changed, and how this composition compared with that of the non-diabetes population. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2021-02-03

    EGB761 ameliorates chronic cerebral hypoperfusion-induced cognitive dysfunction and synaptic plasticity impairment

    ✓ Peer-reviewed Disease mechanisms Aging

    Key finding: The results showed that EGB761 ameliorates spatial cognitive dysfunction occurring after CCH. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2021-02-03

    The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles

    ✓ Peer-reviewed TREM2 and immune genetics Brain communications

    Key finding: Variants in the triggering receptor expressed on myeloid cells 2 gene are linked with an increased risk of dementia, in particular the R47Hhet triggering receptor expressed on myeloid cells 2 variant is linked to late-onset Alzheimer's disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →