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Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity
Rossi Dare L, Garcia A, Alves N, Ventura Dias D, de Souza MA, Mello-Carpes PB.. Behavioural brain research, 2019-03-04
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is characterized by the presence of amyloid-β (Aβ), oxidative damage and neuronal degeneration, which, together with other pathological events, promote progressive memory loss and cognitive decline. Non-pharmacological strategies have been study to provide some protection against the development of AD. Considering that physical exercise neuroprotective effects on prevention of cognitive deficits are well elucidate, it is important clarify the effects of cognitive training, and verify if they are similar or comparable to those observed for physical exercise. Here we divided male adult Wistar rats in six groups: control, which rats were not submitted to any intervention; Aβ, which rats were submitted to hippocampal infusion of Aβ; physical exercise (PE), which rats were submitted to 4 weeks of PE training; PE + Aβ, which rats were submitted to 4 weeks of PE training followed by hippocampal infusion of Aβ; cognitive exercise (CE), which rats were submitted to 4 weeks of CE training; and, CE + Aβ, which rats were submitted to 4 weeks of CE training followed by hippocampal infusion of Aβ. Ten days after Aβ infusion, short (STM) and long-term (LTM) object recognition memory, as well as hippocampal oxidative stress (ROS levels by DCFH test), lipid peroxidation (TBARS), total antioxidant capacity (FRAP) and hippocampal histology were evaluated. Both PE and CE were effective in protect cognitive function against memory deficits related to Aβ neurotoxicity, preventing oxidative stress and damage and hippocampal cellular disorganization. So, cognitive training seems to be as good as physical training in the prevention of memory deficits related to Aβ and seems to share some mechanisms of actions, as oxidative stress prevention.
Key findings
- Considering that physical exercise neuroprotective effects on prevention of cognitive deficits are well elucidate, it is important clarify the effects of cognitive training, and verify if they are similar or comparable to those observed for physical exercise.
- Here we divided male adult Wistar rats in six groups: control, which rats were not submitted to any intervention; Aβ, which rats were submitted to hippocampal infusion of Aβ; physical exercise (PE), which rats were submitted to 4 weeks of PE training; PE + Aβ, which rats were submitted to 4 weeks of PE training followed by hippocampal infusion of Aβ; cognitive exercise (CE), which rats were submitted to 4 weeks of CE training; and, CE + Aβ, which rats were submitted to 4 weeks of CE training followed by hippocampal infusion of Aβ.
- Ten days after Aβ infusion, short (STM) and long-term (LTM) object recognition memory, as well as hippocampal oxidative stress (ROS levels by DCFH test), lipid peroxidation (TBARS), total antioxidant capacity (FRAP) and hippocampal histology were evaluated.
- Both PE and CE were effective in protect cognitive function against memory deficits related to Aβ neurotoxicity, preventing oxidative stress and damage and hippocampal cellular disorganization.
- So, cognitive training seems to be as good as physical training in the prevention of memory deficits related to Aβ and seems to share some mechanisms of actions, as oxidative stress prevention.
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Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 22 of the 58 points we could judge it on, which is 38 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Behavioural brain research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30844418) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 22 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 22 of the 58 points we could judge it on is 38 out of 100. |
| Total | 38 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Rossi Dare, L., Garcia, A., Alves, N., Ventura Dias, D., de Souza, M. A., & Mello-Carpes, P. B. (2019). Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity. Behavioural brain research. https://doi.org/10.1016/j.bbr.2019.03.007
Vancouver
Rossi Dare L, Garcia A, Alves N, Ventura Dias D, de Souza MA, Mello-Carpes PB. Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity. Behavioural brain research. 2019. doi:10.1016/j.bbr.2019.03.007. PMID: 30844418.
BibTeX
@article{rossidare2019-30844418,
author = {Rossi Dare, L. and Garcia, A. and Alves, N. and Ventura Dias, D. and de Souza, M. A. and Mello-Carpes, P. B.},
title = {{Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity}},
journal = {Behavioural brain research},
year = {2019},
doi = {10.1016/j.bbr.2019.03.007},
pmid = {30844418},
url = {https://doi.org/10.1016/j.bbr.2019.03.007}
}
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