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EEG evidence of compensatory mechanisms in preclinical Alzheimer’s disease
Sinead Gaubert, Federico Raimondo, Marion Houot, Marie‐Constance Corsi, Lionel Naccache, Jacobo Diego Sitt, Bertrand Hermann, Delphine Oudiette et al.. Brain, 2019-05-13
Topic: Brain imaging, connectivity and assessment
Neurodegeneration was associated with a widespread increase of median spectral frequency. We found a non-linear relationship between amyloid burden and EEG metrics in neurodegeneration-positive subjects, either following a U-shape curve for delta power or an inverted U-shape curve for the other metrics, meaning that EEG patterns are modulated differently depending on the degree of amyloid burden. Together, these results indicate that EEG metrics are useful biomarkers for the preclinical stage of Alzheimer's disease.
Key findings
- Neurodegeneration was associated with a widespread increase of median spectral frequency.
- We found a non-linear relationship between amyloid burden and EEG metrics in neurodegeneration-positive subjects, either following a U-shape curve for delta power or an inverted U-shape curve for the other metrics, meaning that EEG patterns are modulated differently depending on the degree of amyloid burden.
- Together, these results indicate that EEG metrics are useful biomarkers for the preclinical stage of Alzheimer's disease.
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Study details
- Participants314
- Evidence strengthModerate
How this study scored 57/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 33 of the 58 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 314 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31211359) |
| Free to read | 2 / 2 | Free to read |
| Points | 33 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 33 of the 58 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
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Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Gaubert, S., Raimondo, F., Houot, M., Corsi, M., Naccache, L., Sitt, J. D., et al. (2019). EEG evidence of compensatory mechanisms in preclinical Alzheimer’s disease. Brain. https://doi.org/10.1093/brain/awz150
Vancouver
Gaubert S, Raimondo F, Houot M, Corsi M, Naccache L, Sitt JD, et al. EEG evidence of compensatory mechanisms in preclinical Alzheimer’s disease. Brain. 2019. doi:10.1093/brain/awz150. PMID: 31211359.
BibTeX
@article{gaubert2019-31211359,
author = {Gaubert, Sinead and Raimondo, Federico and Houot, Marion and Corsi, Marie‐Constance and Naccache, Lionel and Sitt, Jacobo Diego and Hermann, Bertrand and Oudiette, Delphine and others},
title = {{EEG evidence of compensatory mechanisms in preclinical Alzheimer’s disease}},
journal = {Brain},
year = {2019},
doi = {10.1093/brain/awz150},
pmid = {31211359},
url = {https://doi.org/10.1093/brain/awz150}
}
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