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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 326–350 of 27,380 studies, newest first · page 14 of 1096.

September 2026 25

  1. 2026-09-29

    Associations between objectively measured smartphone screen time and ikigai in community-dwelling older adults: roles of physical function and social frailty

    ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research Square

    Key finding: Although smartphone usage time is not directly associated with ikigai in older adults, it may reflect preserved physical and cognitive abilities required to navigate digital environments. +4 more findings

    Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  2. 2026-09-29

    APOE Genotype and Fluid Biomarkers of Blood-Brain Barrier Integrity: A Systematic Review and Meta-Analysis

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

    Key finding: Apolipoprotein E (APOE) genotype is theorised to influence dementia risk partly through effects on blood–brain barrier (BBB) function, but clinical studies examining APOE effects on BBB biomarkers report inconsistent results. +4 more findings

    Scored 56 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  3. 2026-09-29

    Plasma immune signatures associate with neurodegeneration in frontotemporal lobar degeneration

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: In exploratory full-cohort models, the multivariate CNS signature achieved an area under the curve of 0.93, compared with 0.82 for the multivariate inflammation signature. +3 more findings

    Scored 42 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  4. 2026-09-29

    Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

    Key finding: Symptomatic DIAD participants who had been treated for ∼ 4 years with anti-Aβ monoclonal antibodies (gantenerumab, n=4 or solanezumab, n=4) were compared with untreated, symptomatic DIAD mutation carriers (n=40) and with age-relevant non-DIAD controls with modest or no plaque pathology (n=18). +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  5. 2026-09-28

    Phenome-wide and proteomic analysis of APOE alleles across different ancestries in the All of Us Research Program

    ⚠ Preprint — not yet peer-reviewed Lewy body dementia medRxiv

    Key finding: We identified 27 phenotypes associated with APOE, mainly in neurological and lipid-related traits. +4 more findings

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  6. 2026-09-28

    Examining the Clinical Utility of Deep Learning Models for Perivascular Space Segmentation in Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

    Key finding: We evaluated overall, voxel, object, and lesion-wise Dice; stratified performance by region, diagnosis, scanner, PVS severity, and white matter hyperintensity (WMH) burden; and tested whether model-derived PVS burden reproduced ground-truth derived associations with AD-related biomarkers. +3 more findings

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  7. 2026-09-28

    Endosomal pH Triggers Amyloid β Oligomerization and Maladaptive Phenotypic Plasticity in Alzheimers Disease

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

    Key finding: Systematic curation of NHE6 patient variants indicates that loss-of-function is associated with late regression, consistent with progressive endosomal hyperacidification, supporting a conceptual framework where early compensation transitions to neurodegeneration. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  8. 2026-09-28

    Early life social isolation primes flies for more rapid TDP-43 dependent neurodegeneration later in life

    ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

    Key finding: But epidemiological evidence suggests psychological stressors such as social isolation and loneliness are also associated with increased risks of neurodegenerative disease [1–8]. +3 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  9. 2026-09-28

    Age-dependent associations of sleep duration and insomnia symptoms with cognitive decline across five decades of adult life: a multi-cohort longitudinal study

    ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

    Key finding: In the English Longitudinal Study of Ageing (ELSA: n=9,473, median age 64, range 50 to ≥90), linear mixed-effects models examined age-specific differences in cognitive change (recall and fluency) associated with sleep duration, difficulty falling asleep, nocturnal awakenings, incorporating sleep-by-age-by-time interactions, with initial adjustment for sociodemographic factors and further adjustment for health and lifestyle factors. +4 more findings

    Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  10. 2026-09-28

    In silico design and physicochemical characterisation of a dual-action intranasal nanoparticle formulation for Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed Treatments Research Square

    Key finding: These findings identify this approach as a mechanistically grounded candidate warranting further in-vitro and in-vivo validation.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  11. 2026-09-28

    Tau-PET subtype modifies the association between plasma p-tau217 and memory in Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: Tau-PET subtype modified the p-tau217–memory association, suggesting that the cognitive implications of plasma p-tau217 may vary with tau topography. +3 more findings

    Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  12. 2026-09-27

    Neurodegeneration-inducing macromolecules exit the brain via nanovascular conduits formed by reticular fibroblasts

    ⚠ Preprint — not yet peer-reviewed Vascular contributions bioRxiv

    Key finding: They course through the pial and arachnoid layers to span the CSF space, wrapping the brain and cranial nerves. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  13. 2026-09-27

    Cofilin Suppresses Tau-Induced Defects in Dense-Core Granule Formation and Aβ-Induced Neurodegeneration

    ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv

    Key finding: Using the prostate-like secondary cell (SC) in Drosophila , we recently showed that Aβ modulates normal APP- and membrane-associated protein aggregation in the dense-core granule (DCG) compartments of the regulated secretory pathway by interfering with subsequent membrane:DCG dissociation. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  14. 2026-09-26

    Association of apolipoprotein E gene with risk, cognition, and prognosis of epilepsy

    ✓ Peer-reviewed Genetics Human genetics

    Key finding: The presence of the APOE ε4 allele was associated with an increased risk of epilepsy, particularly late-onset epilepsy, but the difference in the proportion of APOE ε4 carriers compared with controls in post-stroke epilepsy varied by condition. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2026-09-26

    Public awareness of the hearing loss-dementia link and self-reported behavioral changes in middle- to older-aged Canadians

    ⚠ Preprint — not yet peer-reviewed Prevention and risk medRxiv (preprint)

    Key finding: Education, dementia concern, older age, and female gender were associated with awareness. +1 more finding

    Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  16. 2026-09-25

    rTMS renews long-tract myelination to improve AD cognitive function predicted by baseline myelin and E-field

    ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment Research Square

    Key finding: This study reveals a myelin-mediated mechanism of rTMS action in AD, demonstrating the potential of promoting myelination as a novel therapeutic strategy for alleviating AD-related cognitive impairment. +2 more findings

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  17. 2026-09-25

    Caregiver burden and mood changes among unpaid caregivers of older adults living with dementia

    ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

    Key finding: Depressive and anxiety symptoms were more pronounced among caregivers with longer caregiving duration (p = 0.01; p = 0.001) and those living with the care recipient (p = 0.04; p = 0.02). +3 more findings

    Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  18. 2026-09-25

    Thalamocortical correlates of sleep spindle and slow oscillation dysfunction in Lewy body disorders

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

    Key finding: Within LBD, reduced thalamic volume was associated with lower spindle density and weaker slow spindle–SO coupling.

    Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  19. 2026-09-25

    Evidence of P-glycoprotein mediated bidirectional transport of beta-amyloid (Ab40 and Ab42) through CLEFF4 cells

    ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE Research Square

    Key finding: 2µM FAM labelled β-amyloid 1–40 was transported through CLEFF4 cells with an apparent permeability (Papp) of 4.47x10 − 6 cm/sec in the efflux direction (Basolateral (Bas) to apical (Ap)) while Ap to Bas direction was only 1.67x10 − 6 cm/sec. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  20. 2026-09-25

    A single-nuclei multiomics resource across four brain regions prioritises human neural cell types influencing brain-related traits

    ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv

    Key finding: Genetic studies have identified thousands of variants associated with brain-related traits.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  21. 2026-09-25

    Profiling of Aggregated Amyloid β42-induced Proteomic Alterations in KOLF2.1J Induced Pluripotent Stem Cell-derived Neurons

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers bioRxiv

    Key finding: Proteomic profiling revealed extensive gene alterations in pathways associated with synaptic function, neuronal maintenance, and AD pathogenesis, such as the upregulation of APOE. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  22. 2026-09-25

    AT(N)-Anchored Multimodal Deep Learning for Alzheimer’s Staging: A Taxonomy and Continuous Burden Index for Low-Resource Settings

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers Preprints.org

    Key finding: We present a systematic scoping review synthesizing 146 included full-text publications (2018–2026) across four multidisciplinary evidence streams, establishing a novel architectural taxonomy that maps deep learning architectural families directly to AT(N) biological targets and connects model inductive biases to specific biomarker categories. +4 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  23. 2026-09-25

    Epilepsy Mechanisms in Down Syndrome: Genetic and Pathophysiological Perspectives Across the Lifespan

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of clinical medicine

    Key finding: Seizures are a frequent comorbidity in individuals with Down syndrome and can exert significant negative consequences on cognitive capacity and quality of life.

    Full summary, score breakdown and related studies → Original source

  24. 2026-09-25

    A neurocognitive speech taxonomy for voice biomarkers of Alzheimer's disease

    ⚠ Preprint — not yet peer-reviewed Disparities medRxiv (preprint)

    Key finding: NST showed stable cross-cohort structure (Mantel r = 0.71-0.77) and differentiated MCI (d = -0.39) and AD biomarker status (d = -0.23). +3 more findings

    Scored 38 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  25. 2026-09-25

    Diagnostic accuracy of remote self-administered digital cognitive assessment by clinical diagnosis and Alzheimer's disease PET imaging biomarkers

    ⚠ Preprint — not yet peer-reviewed Getting a diagnosis medRxiv (preprint)

    Key finding: MTD showed excellent discrimination of CU versus MCI/DEM (AUC=.89; 95% CI=.87-.92), and discriminability remained high for CU versus MCI (AUC=.88; 95% CI=.85-.92). +4 more findings

    Scored 38 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →