Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,701–12,725 of 27,380 studies, newest first · page 509 of 1096.
July 2019 20
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2019-07-01
Palliative care provision in long-term care facilities differs across Europe: Results of a cross-sectional study in six European countries (PACE)
59/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: The late initiation of palliative care (especially when advance care planning is lacking) and palliative care for residents without cancer, dementia or closely involved relatives deserve attention in all countries.
Full summary, score breakdown and related studies → Original source
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2019-07-01
Consequences of Metabolic Disruption in Alzheimer's Disease Pathology
38/100 ✓ Peer-reviewed Disease mechanisms Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Key finding: Besides these genetic risk factors, having type 2 diabetes (T2D), a chronic metabolic disease, is known to increase the AD risk by at least 2-fold when these individuals age, conforming to Sims-Robinson et al. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
P1‐243: BIOMARKER‐GUIDED STRATIFICATION APPROACH OF THE CLINICAL CONTINUUM OF ALZHEIMER'S DISEASE USING UNSUPERVISED CLUSTERING METHODS
41/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia
Key finding: We found 5 distinct clusters of subjects (N=38, N=16, N=24, N=14, N=21) with a composition statistically independent from that obtained using available clinical diagnostic criteria (each cluster included all phenotypical groups). +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
P1‐572: EFFECTS OF NEIGHBORHOOD DISADVANTAGE ON COGNITION IN AFRICAN‐AMERICAN OLDER ADULTS
29/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia
Key finding: Overall health is significantly impacted by where one lives. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
P2‐435: NEIGHBORHOOD DISADVANTAGE IS ASSOCIATED WITH NEUROPATHOLOGICALLY CONFIRMED ALZHEIMER'S DISEASE
38/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia
Key finding: Social determinants of health, such as neighborhood disadvantage, have been linked to an increased risk of clinical dementia syndrome; however, their association with neuropathologically confirmed Alzheimer's disease (AD) remains unknown. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
P3‐617: PATHWAY TO DIAGNOSIS: PERSONS WITH DEMENTIA AND CAREGIVER EXPERIENCES REACHING A DIAGNOSIS
29/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia
Key finding: Overall, the pathway to diagnosis (i.e., time from signs/symptoms recognition to diagnosis) ranged from 2 to 15 years. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-07-01
P4‐444: EMERGENCY PREPAREDNESS PLANNING FOR PEOPLE LIVING WITH DEMENTIA: A COMPARISON OF COUNTY LEVEL DEMOGRAPHIC CHARACTERISTICS WITH RECENT DEMENTIA PREVALENCE ESTIMATES IN CALIFORNIA COUNTIES
30/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia
Key finding: We found both the three counties with the highest level of ADRD prevalence and population of adults aged 65 years and older were Los Angeles, Orange, and San Diego – also the three most populous California counties overall. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-07-01
F4‐01‐05: RACIAL AND ETHNIC DIFFERENCES IN AMYLOID PET POSITIVITY IN THE IDEAS STUDY
44/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia
Key finding: Compared to Whites, Blacks/African Americans and Latinos/Hispanics have 50-100% higher rates of clinical AD, while Asians/Asian Americans have markedly lower rates. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
52/100 ✓ Peer-reviewed Brain tissue and pathology Neuron
Key finding: To yield insights into the role of SGs in pathophysiology, we performed a high-content screen to identify small molecules that alter SG properties in proliferative cells and human iPSC-derived motor neurons (iPS-MNs). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Down syndrome, Alzheimer disease, and cerebral amyloid angiopathy: The complex triangle of brain amyloidosis
43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Developmental neurobiology
Key finding: The overexpression of the Amyloid Precursor Protein, present in chromosome 21, leads to β-amyloid deposition that results in Alzheimer disease (AD) and, in most cases, also to cerebral amyloid angiopathy (CAA) neuropathology. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Associations between vascular risk factors and brain MRI indices in UK Biobank
63/100 ✓ Peer-reviewed Risk factors European heart journal
Key finding: Higher levels of VRFs were associated with poorer brain health across grey and white matter macrostructure and microstructure. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
A National Examination Of Long-Term Care Setting, Outcomes, And Disparities Among Elderly Dual Eligibles
44/100 ✓ Peer-reviewed Disparities Health affairs (Project Hope)
Key finding: Using national Medicaid claims data on older adults enrolled in both Medicare and Medicaid, we found that overall hospitalization rates were similar for HCBS and nursing facility users, although nursing facility users were generally sicker as reflected in their claims history. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-07-01
Physical activity and muscle-brain crosstalk
52/100 ✓ Peer-reviewed Caregiving Nature reviews. Endocrinology
Key finding: The fact that exercise is sensed by the brain suggests that muscle-induced peripheral factors enable direct crosstalk between muscle and brain function.
Full summary, score breakdown and related studies → Original source
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2019-07-01
Evolution of prodromal Parkinson's disease and dementia with Lewy bodies: a prospective study
64/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology
Key finding: At 7-9 years before phenoconversion, slight urinary dysfunction and subtle cognitive decline could be detected. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Preventing dementia by preventing stroke: The Berlin Manifesto
56/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This suggests that whatever factors cause these trends are potentially modifiable. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Change in Depression, Confidence, and Physical Function Among Older Adults With Mild Cognitive Impairment
66/100 ✓ Peer-reviewed Treatments Journal of geriatric physical therapy (2001)
Key finding: Change in occupational performance predicted change in depressive symptoms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Aerobic Exercise Sustains Performance of Instrumental Activities of Daily Living in Early-Stage Alzheimer Disease
66/100 ✓ Peer-reviewed Treatments Journal of geriatric physical therapy (2001)
Key finding: Our analysis extends recent work by revealing specific benefits for instrumental activities of daily living for individuals in the early stages of AD and supports the value of exercise for individuals with cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition
55/100 ✓ Peer-reviewed Genetics Annals of neurology
Key finding: The results showed different pattern of APOE contribution in PRS risk predictions of AD/MCI and amyloid deposition. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB
51/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: Elevated LDL-C levels were associated with higher probability of having EOAD, and EOAD cases were enriched for rare coding variants in APOB, which codes for the major protein of LDL-C. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease
76/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: The NfL level was increased at baseline in patients with mild cognitive impairment and AD dementia (mean levels: cognitive unimpairment, 32.1 ng/L; mild cognitive impairment, 37.9 ng/L; and AD dementia, 45.9 ng/L; P Conclusions and relevance The findings suggest that plasma NfL can be used as a noninvasive biomarker associated with neurodegeneration in patients with AD and may be useful to monitor effects in trials of disease-modifying drugs. +2 more findings
Full summary, score breakdown and related studies → Original source
June 2019 5
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2019-06-29
Combustion- and friction-derived magnetic air pollution nanoparticles in human hearts
45/100 ✓ Peer-reviewed Risk factors Environmental research
Key finding: Metropolitan Mexico City (MMC) young residents have abundant brain CFDNPs associated with AD pathology. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-29
FDG-PET as an independent biomarker for Alzheimer's biological diagnosis: a longitudinal study
64/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's research & therapy
Key finding: The prevalence of A+T+N+F+ profile was 66.24% in clinically diagnosed AD dementia patients; similarly, the majority of individuals with reduced FDG-PET were AD dementia subjects.
Full summary, score breakdown and related studies → Original source
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2019-06-28
Exploring Disasters through the Eyes of Residential Nursing Home Caregivers
39/100 ✓ Peer-reviewed Health systems and care delivery Social work in public health
Key finding: Their experiences suggest that coping with the disasters as caregivers was complex and unexpected, and it should not be misunderstood to imply that their resilience is predictable and expected.
Full summary, score breakdown and related studies → Original source
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2019-06-28
Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease
50/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Plasma tau was higher in patients with AD than cognitively normal controls (P < .001, area under the receiver operating characteristic curve = 0.79) similarly to CSF tau and CSF P-tau and was negatively correlated with cognition in AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-28
The Multilingual Naming Test (MINT) as a Measure of Picture Naming Ability in Alzheimer's Disease
51/100 ✓ Peer-reviewed Long-term cohort studies Journal of the International Neuropsychological Society : JINS
Key finding: The present study investigated the ability of the Multilingual Naming Test (MINT), a picture naming test recently added to the National Alzheimer's Coordinating Center's (NACC) Uniform Data Set neuropsychological test battery, to detect naming impairment (i.e., dysnomia) across stages of Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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