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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 12,201–12,225 of 27,380 studies, newest first · page 489 of 1096.

December 2019 25

  1. 2019-12-16

    Social inequalities in multimorbidity, frailty, disability, and transitions to mortality: a 24-year follow-up of the Whitehall II cohort study

    ✓ Peer-reviewed Prevention and risk The Lancet. Public health

    Key finding: Multimorbidity (hazard ratio [HR] 4·12 [95% CI 3·41-4·98]), frailty (HR 2·38 [95% CI 1·93-2·93]), and disability (HR 1·73 [95% CI 1·34-2·22]) were associated with increased risk of mortality; these associations were not modified by socioeconomic status. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2019-12-16

    Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

    ✓ Peer-reviewed Biomarkers Acta neuropathologica communications

    Key finding: Activated Caspase-6 (Casp6) is associated with age-dependent cognitive impairment and Alzheimer disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2019-12-15

    OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer Disease

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv

    Key finding: OASIS-3 is a compilation of MRI and PET imaging and related clinical data for 1098 participants who were collected across several ongoing studies in the Washington University Knight Alzheimer Disease Research Center over the course of 15 years. +3 more findings

    Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  4. 2019-12-14

    The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy

    ✓ Peer-reviewed Vascular contributions International journal of molecular sciences

    Key finding: Despite the fact that CAA is highly associated with the accumulation of Aβ, other types of amyloids have been shown to associate with the vasculature. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2019-12-14

    A novel multi-modal machine learning based approach for automatic classification of EEG recordings in dementia

    ✓ Peer-reviewed Digital health tools Neural networks : the official journal of the International Neural Network Society

    Key finding: Comparative results show that when the concatenation of CWT and BiS features (denoted as multi-modal (CWT+BiS) features) is used as input, the Multi-Layer Perceptron (MLP) classifier outperforms all other models, specifically, the Autoencoder (AE), Logistic Regression (LR) and Support Vector Machine (SVM).

    Full summary, score breakdown and related studies → Original source

  6. 2019-12-13

    A new Centiloid method for 18F-florbetaben and 18F-flutemetamol PET without conversion to PiB

    ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging

    Key finding: Following the conversion of FBB or FMM SUVRs into CL units, a direct relationship was formed between the FBB or FMM SUVRs and the CL units using dcCL method (FBB dcCL = 151.42 × FBB dcSUVR - 142.24 and FMM dcCL = 148.52 × FMM dcSUVR - 137.09). +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2019-12-13

    Repeated lumbar punctures within 3 days may affect CSF biomarker levels

    ✓ Peer-reviewed Tau biomarkers Fluids and barriers of the CNS

    Key finding: The result corroborates findings in studies with repeated CSF collection via indwelling lumbar catheters, and needs to be addressed in, for instance, pharmacodynamic studies employing these techniques.

    Full summary, score breakdown and related studies → Original source

  8. 2019-12-13

    Predicting clinical decline and conversion to Alzheimer's disease or dementia using novel Elecsys Aβ(1-42), pTau and tTau CSF immunoassays

    ✓ Peer-reviewed Cognitive tests and assessment Scientific reports

    Key finding: CSF samples from patients in two multicentre longitudinal studies (ADNI, n = 619; BioFINDER, n = 431) were analysed. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2019-12-13

    The Spatial-Temporal Ordering of Amyloid Pathology and Opportunities for PET Imaging

    ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: Understanding the regional-temporal evolution of amyloid pathology may enable earlier identification of subjects in the Alzheimer Disease pathologic continuum, as well as a finer-grained assessment of pathology beyond traditional dichotomous measures. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2019-12-12

    Alzheimer's Disease and Parkinson's Disease: A Nutritional Toxicology Perspective of the Impact of Oxidative Stress, Mitochondrial Dysfunction, Nutrigenomics and Environmental Chemicals

    ✓ Peer-reviewed Risk factors Journal of the American College of Nutrition

    Key finding: These innovations can be benchmarked on firm understanding of nutrigenomics and the personalized management of individuals at risk.

    Full summary, score breakdown and related studies → Original source

  11. 2019-12-12

    Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research

    ✓ Peer-reviewed Risk factors Sleep medicine reviews

    Key finding: An important question for sleep and AD researchers is whether OSA's heterogeneity results in varying cognitive-outcomes in older-adults compared to middle-aged adults. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2019-12-12

    Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis

    ✓ Peer-reviewed Treatments Alzheimer's research & therapy

    Key finding: PET amyloid levels were consistent with sparse-to-no neuritic amyloid-β plaques in 51% of patients after 2 years of therapy. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2019-12-12

    A Review on MS-Based Blood Biomarkers for Alzheimer's Disease

    ✓ Peer-reviewed Biomarkers Neurology and therapy

    Key finding: Furthermore, blood biomarkers are highly appreciated because they are minimally invasive and more accessible in primary care and in clinical studies. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2019-12-12

    Childhood Adversity and Neural Development: A Systematic Review

    ✓ Peer-reviewed Hippocampus size on brain scans Annual review of developmental psychology

    Key finding: We evaluate two conceptual models of adversity and neurodevelopment-the dimensional model of adversity and stress acceleration model-in a systematic review of 109 studies using MRI-based measures of neural structure and function in children and adolescents. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2019-12-12

    Neurophysiological Markers of Alzheimer's Disease: Quantitative EEG Approach

    ✓ Peer-reviewed Disease mechanisms Neurology and therapy

    Key finding: Numerous studies have shown that qEEG measures can detect disruptions in activity, topographical distribution and synchronization of neuronal (synaptic) activity such as generalized EEG slowing, reduced global synchronization and anteriorization of neuronal generators of fast-frequency resting-state EEG activity in patients along the AD continuum.

    Full summary, score breakdown and related studies → Original source

  16. 2019-12-12

    HHV-6A infection induces amyloid-beta expression and activation of microglial cells

    ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's research & therapy

    Key finding: The control of viral infections in the brain involves the activation of microglial cells, the macrophages of the brain that are constantly surveying the central nervous system, and the production of amyloid-beta (Aβ) as an anti-microbial molecule. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2019-12-12

    Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease

    ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

    Key finding: Intellectual disability (ID) found in Down syndrome (DS), which is characterized by an extra copy of 234 genes on Chr21 is poorly understood. +3 more findings

    Scored 18 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  18. 2019-12-12

    Salivary Biomarkers for Alzheimer's Disease and Related Disorders

    ✓ Peer-reviewed Biomarkers Neurology and therapy

    Key finding: The advances in ultra-sensitive detection methods has highlighted blood biomarkers (e.g. amyloid-β and neurofilament light) as a valuable and realistic tool in a diagnostic or screening process. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2019-12-11

    Changes in the Place of Death in the United States

    ✓ Peer-reviewed End-of-life care New England Journal of Medicine

    n d e n c e Changes in the Place of Death in the United States To the Editor: Where people die is an impor tant determinant of patient and caregiver expe rience.

    Full summary, score breakdown and related studies → Original source

  20. 2019-12-11

    Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways

    ✓ Peer-reviewed Brain tissue and pathology Nature reviews. Neurology

    Key finding: The pathogenic pathways of CAA and AD intersect at the levels of Aβ generation, its circulation within the interstitial fluid and perivascular drainage pathways and its brain clearance, but diverge in their mechanisms of brain injury and disease presentation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2019-12-10

    Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A machine learning approach

    ✓ Peer-reviewed Digital health tools NeuroImage

    Key finding: We implemented machine-learning algorithms to evaluate the prediction power of neurocognitive biomarkers (behavioral and imaging measures) for classifying two neurodegenerative conditions -Alzheimer Disease (AD) and behavioral variant frontotemporal dementia (bvFTD)- across three different countries (>200 participants). +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2019-12-10

    Machine learning models to predict onset of dementia: A label learning approach

    ✓ Peer-reviewed Digital health tools Alzheimer's & dementia (New York, N. Y.)

    Key finding: The ability of the model to discriminate incident cases of dementia implies that it can be a worthwhile tool to screen patients for trial recruitment and patient management.

    Full summary, score breakdown and related studies → Original source

  23. 2019-12-10

    Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort

    ✓ Peer-reviewed Digital health tools Molecular psychiatry

    Key finding: However, these findings are largely based on cross-sectional associations which can confuse age differences with cohort differences. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2019-12-10

    Dementia and caregiver burden: A three-year longitudinal study

    ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry

    Key finding: High levels of caregiver burden are present in a large proportion of caregivers of people with dementia and this increases over time for those without services. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2019-12-09

    A meta-analysis of the association between caregiver burden and the dependent's illness

    ✓ Peer-reviewed Caregiving Journal of women & aging

    Key finding: The caregiver burden is frequently used to refer to the physical and psychological problems that may arise from caring for a dependent relative. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →