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Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I et al.. Brain : a journal of neurology, 2019-06-01
Topic: Brain proteins, microglia and lab models
LATE-NC is a common TDP-43 proteinopathy, associated with an amnestic dementia syndrome that mimicked Alzheimer's-type dementia in retrospective autopsy studies. In community-based autopsy cohorts, ∼25% of brains had sufficient burden of LATE-NC to be associated with discernible cognitive impairment. Neuroimaging studies demonstrated that subjects with LATE-NC also had atrophy in the medial temporal lobes, frontal cortex, and other brain regions. The discovery of these genetic risk variants indicate that LATE shares pathogenetic mechanisms with both frontotemporal lobar degeneration and Alzheimer's disease, but also suggests disease-specific underlying mechanisms.
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APA 7th
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., et al. (2019). Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain : a journal of neurology. https://doi.org/10.1093/brain/awz099
Vancouver
Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, et al. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain : a journal of neurology. 2019. doi:10.1093/brain/awz099. PMID: 31039256.
BibTeX
@article{nelson2019-31039256,
author = {Nelson, P. T. and Dickson, D. W. and Trojanowski, J. Q. and Jack, C. R. and Boyle, P. A. and Arfanakis, K. and Rademakers, R. and Alafuzoff, I. and others},
title = {{Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report}},
journal = {Brain : a journal of neurology},
year = {2019},
doi = {10.1093/brain/awz099},
pmid = {31039256},
url = {https://doi.org/10.1093/brain/awz099}
}
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Key findings
- LATE-NC is a common TDP-43 proteinopathy, associated with an amnestic dementia syndrome that mimicked Alzheimer's-type dementia in retrospective autopsy studies.
- In community-based autopsy cohorts, ∼25% of brains had sufficient burden of LATE-NC to be associated with discernible cognitive impairment.
- Neuroimaging studies demonstrated that subjects with LATE-NC also had atrophy in the medial temporal lobes, frontal cortex, and other brain regions.
- The discovery of these genetic risk variants indicate that LATE shares pathogenetic mechanisms with both frontotemporal lobar degeneration and Alzheimer's disease, but also suggests disease-specific underlying mechanisms.
Why it matters
This report describes LATE-NC, a common TDP-43 proteinopathy that can mimic Alzheimer's-type dementia and was found in about 25% of brains in community-based autopsy cohorts. It shares some genetic risk factors with both frontotemporal lobar degeneration and Alzheimer's disease, but also has disease-specific mechanisms.
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Study details
- Evidence strengthLow
How this study scored 67/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,547 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 171.9 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 6 / 6 | Cited 96.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 5 / 6 | Cited by 119 other studies in this library |
| Still being cited | 4 / 4 | Cited 647 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Julie A. Schneider: h-index 151 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | University of Washington: institution h-index 3,540 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 23 institution(s) in 6 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31039256) |
| Free to read | 2 / 2 | Free to read |
| Total | 67 / 100 | — |
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