Newest studies

Boston Naming Test

10/100 ⚠ Report — not peer-reviewed Cognitive tests and assessment

Full summary, score breakdown and related studies → Original source

Treatment of Mania in Dementia With Electroconvulsive Therapy

28/100 ✓ Peer-reviewed How common it is Psychopharmacology Bulletin

Key finding: Because it is so highly associated with behavioral agitation, mania has a significant impact on patient management, and can often lead to the institutionalization of difficult patients. +2 more findings

• Treatments

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The Incidence of Vascular Dementia in Canada: A Comparison with Europe and East Asia

35/100 ✓ Peer-reviewed Risk factors Neuroepidemiology

Key finding: Vascular dementia (VaD) is the second commonest subtype of dementia after Alzheimer's disease (AD).

• Risk Factors
• Other Dementias

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The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease

41/100 ✓ Peer-reviewed Brain tissue and pathology Neuroscience

Key finding: Plaques with a spherical profile were defined as either diffuse, fibrillar or dense-cored using Thioflavin S staining or immunolabelling for beta-amyloid. +3 more findings

• Brain Biology

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Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)

63/100 ✓ Peer-reviewed Brain tissue and pathology Lancet (London, England)

Key finding: We have undertaken a large unselected, community-based neuropathology study in an elderly (70-103 years) UK population in relation to prospectively evaluated dementia status. +3 more findings

• Brain Biology

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Blood pressure and risk of dementia: results from the Rotterdam study and the Gothenburg H-70 Study

62/100 ✓ Peer-reviewed Long-term cohort studies Dementia and geriatric cognitive disorders

Key finding: The association between blood pressure and dementia is debated. +3 more findings

• Risk Factors

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Cortical change in Alzheimer's disease detected with a disease-specific population-based brain atlas

62/100 ✓ Peer-reviewed Cognitive tests and assessment Cerebral cortex (New York, N.Y. : 1991)

Key finding: New computational approaches were used to: (i) distinguish variations in gray matter distribution from variations in gyral patterns; (ii) encode these variations in a brain atlas (n = 46); (iii) create detailed maps localizing gray matter differences across groups. +3 more findings

• Brain Scans

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Codeposition of cystatin C with amyloid-beta protein in the brain of Alzheimer disease patients

43/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology

Key finding: No evidence of cerebral hemorrhage was observed in any of the brains studied. +3 more findings

• Brain Biology

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Tau filament formation in transgenic mice expressing P301L tau

47/100 ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry

Key finding: To determine whether P301L is associated with fibril formation in mice, we expressed the longest human tau isoform, human tau40, with this mutation in transgenic mice by using the neuron-specific mouse Thy1.2 promoter. +2 more findings

• Brain Biology
• Other Dementias

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Proteasomal function is impaired in substantia nigra in Parkinson's disease

47/100 ✓ Peer-reviewed Lewy body dementia Neuroscience letters

Key finding: The accumulation of alpha-synuclein, ubiquitin and other proteins in Lewy bodies in degenerating dopaminergic neurones in substantia nigra in idiopathic Parkinson's disease (PD) suggest that inhibition of normal/abnormal protein degradation may contribute to neuronal death. +1 more finding

• Other Dementias

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Neurodegenerative tauopathies

54/100 ✓ Peer-reviewed Lewy body dementia Annual review of neuroscience

Key finding: Nonetheless, different members of the same kindred often exhibit diverse FTDP-17 syndromes, which suggests that additional genetic or epigenetic factors influence the phenotypic manifestations of neurodegenerative tauopathies.

• Other Dementias
• Genetics
• Brain Biology

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Glial-neurotrophic mechanisms in Down syndrome

32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neural transmission. Supplementum

Key finding: The result is a small but slowly increasing deficit in activity-dependent support by glia cells which produces a gradually increasing abnormality of cortical and subcortical, perhaps especially cholinergic, function.

• Down Syndrome

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Carbohydrate handling enzymes in fetal Down syndrome brain

28/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neural transmission. Supplementum

Key finding: We observed comparable levels of phosphoglycerate mutase, phosphoglycerate kinase 1; fructose-biphosphate aldolase A, fructose bisphosphate aldolase C; ribose-phosphate pyrophosphokinase 1; D-phosphoglycerate dehydrogenase, 6-phosphogluconolactonase; aflatoxin B1 aldehyde reductase 1, aldose reductase; inosine-5'-monophosphate dehydrogenase 2; galactokinase, in brain of fetal controls and DS. +1 more finding

• Down Syndrome

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The brain in Down syndrome

34/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neural transmission. Supplementum

Key finding: Down syndrome (trisomy 21) is a genetic disease with developmental brain abnormalities resulting in early mental retardation and precocious, age dependent Alzheimer-type neurodegeneration. +2 more findings

• Down Syndrome

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Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis

35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neural transmission. Supplementum

Key finding: Accumulating evidence indicates that enhanced apoptosis (programmed cell death) in Down syndrome (DS) may play a role in mental retardation and precocious neurodegeneration of the Alzheimer-type. +2 more findings

• Down Syndrome

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Down syndrome: progress in research

32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Mental retardation and developmental disabilities research reviews

Key finding: This review discusses the research published in the last five years on the behavioral, genetic, medical, and neuroscience aspects of Down syndrome. +1 more finding

• Down Syndrome

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Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome

40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of investigative medicine : the official publication of the American Federation for Clinical Research

Key finding: Increased SOD-1 levels in patients with DS may reflect the overexpression by the trisomic state, as a response to the oxidative stress, as has been proposed in DS by several authors.

• Down Syndrome

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Welding-related parkinsonism: clinical features, treatment, and pathophysiology

56/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Welders were exposed to a mean of 47,144 welding hours. +2 more findings

• Other Dementias

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HIV-associated neurologic disease incidence changes:: Multicenter AIDS Cohort Study, 1990-1998

61/100 ✓ Peer-reviewed How common it is Neurology

Key finding: This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990 to December 1998 in the Multicenter AIDS Cohort Study. +2 more findings

• Risk Factors

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Classification criteria for mild cognitive impairment: a population-based validation study

64/100 ✓ Peer-reviewed How common it is Neurology

Key finding: MCI criteria perform poorly when applied to a representative population sample.

• Early Stage

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Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study

59/100 ✓ Peer-reviewed How common it is Journal of neurology, neurosurgery, and psychiatry

Key finding: The prevalence and the degree of cerebral white matter lesions increased with age. +1 more finding

• Brain Scans

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Anticholinergic effects of medication in elderly patients

40/100 ✓ Peer-reviewed Caregiving The Journal of clinical psychiatry

Key finding: The toxicity is often the result of the cumulative anticholinergic burden of multiple prescription medications and metabolites rather than of a single compound.

• Side Effects
• Treatments

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Clinical validity of the 'mini-mental state' for Spanish speaking communities

55/100 ✓ Peer-reviewed Getting a diagnosis Neuropsychologia

Key finding: The test was administered to 450 subjects (253 control volunteers, 86 mild memory/cognitive impairment without dementia subjects - CIWD and 111 Alzheimer's Disease patients - AD). +4 more findings

• Diagnosis

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Stability of the preclinical episodic memory deficit in Alzheimer's disease

54/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology

Key finding: These results indicate that Alzheimer's disease is characterized by a long preclinical period during which episodic memory deficits are detectable. +1 more finding

• Early Stage
• Brain Biology

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Validation of the Delirium Rating Scale-revised-98: comparison with the delirium rating scale and the cognitive test for delirium

58/100 ✓ Peer-reviewed Getting a diagnosis The Journal of neuropsychiatry and clinical neurosciences

Key finding: Mean and median DRS-R-98 scores significantly (P<0.001) distinguished delirium from each other group.

• Diagnosis

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