Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 276–300 of 27,380 studies, newest first · page 12 of 1096.
October 2026 25
-
2026-10-05
Volumetric Integrity of Frontotemporal and Perisylvian Regions for Predicting Behavioral and Language Impairment in Behavioral FTD: A Structural MRI Study
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv
Key finding: In this bvFTD cohort, structural volumes of key frontotemporal and perisylvian regions did not predict behavioral or language impairments after correction for multiple comparisons. +2 more findings
Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-05
Substituent Effects on Electronic Properties and Acetylcholinesterase Inhibitory Potential of Donepezil Analogues: A DFT, Molecular Docking, and ADMET Study with Dynamics Validation of the Lead Candidate
16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square
Key finding: Moreover, the results of the ADME analysis indicated good oral absorption and blood-brain barrier penetration. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-05
Patterns of GLP-1 Receptor Agonist Initiation Compared With Other Glucose-Lowering and Anti-Obesity Therapies Among Older Adults
16/100 ⚠ Preprint — not yet peer-reviewed Drug development medRxiv
Key finding: We describe the demographic and clinical characteristics of new initiators of GLP-1RAs compared with initiators of alternative therapies, including sodium-glucose cotransporter-2 inhibitors (SGLT2i) and dipeptidyl peptidase-4 inhibitors (DPP-4i). +4 more findings
Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-05
The Somnogenesis System
16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging ScienceOpen Preprints
Key finding: Each hub carries an established, distinct function, and the evidence suggests these functions operate as a dependency chain rather than as independent, parallel contributions, consistent with the proposed existence of a genuine biological system rather than three regions coincidentally active at the same time. +4 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-05
White matter hyperintensities partly mediate genetically predicted blood pressure effects on vascular dementia
16/100 ⚠ Preprint — not yet peer-reviewed Genetics Research Square
Key finding: Genetically predicted BP raises WMH in European and Japanese ancestry. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-05
Large-scale cerebrospinal fluid proteomics identifies diagnostic biomarker candidates across the clinico-pathological continuum of frontotemporal lobar degeneration
16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers bioRxiv
Key finding: In neuropathological subtype contrasts, elevated matrix metalloproteinase MMP10 classified Pick’s disease (PiD) versus other subtypes with near-perfect accuracy across proteomic platforms. +2 more findings
Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-05
Cannabidiol for chronic neuroinflammation: clinical pharmacology and what an interpretable trial will require
16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Authorea Preprints
Key finding: Single-target anti-inflammatories often fail for distinct reasons: many never reach adequate CNS concentrations; those that do may engage only one of many potentially redundant pathways; and suppression can block resolution as well as injury. +4 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-05
Longitudinal Multimodal Retinal Imaging in Cognitively Normal Apolipoprotein E4 Carriers and Noncarriers
68/100 ✓ Peer-reviewed Brain scans and imaging Translational vision science & technology
Key finding: This study analyzed 871 eyes from 439 participants (230 APOE ε4 noncarriers and 209 carriers). +4 more findings
Full summary, score breakdown and related studies → Original source
-
2026-10-04
Genetically distinct neurodegenerative proteinopathies engage overlapping proteostasis components
16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv
Key finding: Nine proteins contributed disproportionately, and only autophagy’s removal significantly reduced similarity. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-04
APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction
16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions bioRxiv
Key finding: Cerebral amyloid angiopathy (CAA), characterized by cerebrovascular amyloid deposition, is strongly associated with Alzheimer’s disease, ischemic injury, and lobar hemorrhages. +3 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-04
DNA polymerase kappa supports repair-associated DNA synthesis and neuronal genome resilience
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv
Key finding: DNA polymerase kappa (POLK), a Y-family translesion synthesis polymerase, is highly expressed in neurons and undergoes an age-associated redistribution from the nucleus to the cytoplasm, suggesting that loss of nuclear POLK may compromise neuronal genome maintenance. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-04
Brain-wide Cerebrospinal Fluid Recirculation Collapse in Alzheimer’s Disease
16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers bioRxiv
Key finding: Collectively, our findings demonstrate that AD dismantles the entire CSF recirculation loop—from macroscopic ventral entry to terminal microvascular efflux—highlighting pericytic and neuronal lipidosis as fundamental drivers of brain fluid stagnation.
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-03
Stage-specific proteomic signatures of synaptopathy in Alzheimer’s disease
16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv
Key finding: These findings guided targeted investigation of candidate plasma markers linked to distinct synaptic processes in two independent proteomic datasets. +1 more finding
Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-02
Hypothalamic tau P301L pathology disrupts pair bonding in monogamous prairie voles
16/100 ⚠ Preprint — not yet peer-reviewed Caregiving bioRxiv
Key finding: In addition, healthy 18-month males paired with a hypothalamic tau-expressing female also showed reduced partner preference, suggesting that pathology exerts vicarious effects on partners. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-02
The Alzheimer’s Disease-associated gene CD2AP regulates permeability of endothelial cells and transendothelial migration of immune cells
16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions bioRxiv
Key finding: Variants at the CD2AP locus, which encodes a branched-actin regulator, are associated with late-onset Alzheimer’s disease (AD), and CD2AP-deficient mice show increased blood-brain barrier (BBB) permeability. +2 more findings
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-02
Alignment with sex-typical brain architecture: Links to mood pathology, sex hormones and transcriptomics of neurodegenerative conditions
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv
Key finding: We tested whether, across sexes, alignment with female-typical, rather than male-typical, patterns of neural functional connectivity (FC) would relate to a diagnosis (adolescent sample) or severity of symptoms (adult sample) associated with internalizing disorders, which tend to be more often diagnosed in females. +1 more finding
Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-02
Distinct Aβ40 and Aβ42 co-assembly pathways with free lipids: Experiment-driven MD study
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv
Key finding: MD results indicate that lipids alter the secondary structure more and interact more avidly with Aβ40 than with Aβ42. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-02
Repetitive RNA Is Present in Prion-Infected Mouse Brains
16/100 ⚠ Preprint — not yet peer-reviewed Drug development Preprints.org
Key finding: Using the software superSTR [5], for detecting repetitive elements in RNA-seq data, repeat expansions were found for the known pathogenic motifs, AGC and AAG, along with other motifs, AAAAC, AAAGG, AAGAG and AGAU, all statistically significant compared to controls, with the Mann-Whitney U-test adjusted for multiple testing. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-02
REM sleep EEG slowing signals basal forebrain integrity in older adults with subjective and mild cognitive impairment
16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging medRxiv
Key finding: Greater REM EEG slowing was associated with smaller NbM volume (all p < 0.05), whereas no significant associations were observed with Ch1–3 volume and non-REM EEG slowing (all p > 0.05). +2 more findings
Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-02
Integrating CSF and EV Proteomes Enhances Biomarker Discovery by Capturing Shared Variation Across Compartments
16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers bioRxiv
Key finding: Where subcompartment data, such as that from extracellular vesicles (EVs), are also measured, separate but parallel analyses of EVs and CSF can obscure their shared disease signal. +4 more findings
Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-02
Memory and Plasma pTau217 Refine Prognosis in Down Syndrome
47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Annals of neurology
Key finding: Individuals with Down syndrome (DS) are at high risk for Alzheimer's disease (AD), yet accessible tools for routine clinical screening of AD in individuals with DS remain limited. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2026-10-01
Evaluating Patient Representation Strategies for Early Prediction of Alzheimer’s Disease and Related Dementias from Longitudinal EHRs
16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment Research Square
Key finding: Count-based models achieved the strongest overall discrimination and calibration. +2 more findings
Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-01
Decoding Dementia from Sweat: A Proof-of-Concept Label-Free Raman Fingerprinting of EVs
16/100 ⚠ Preprint — not yet peer-reviewed Lewy body dementia medRxiv
Key finding: Distinct Raman spectral fingerprints were identified in sweat EVs from dementia patients compared with HC. +2 more findings
Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-01
PDE2A Modulation Attenuates Aβ-Induced Neuronal Injury and Associated Oxidative, Inflammatory, and Apoptotic Responses
16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Research Square
Key finding: Across cellular and animal Aβ injury models, BML-288 attenuated oxidative and inflammatory disturbances, modulated apoptosis-related protein expression, and improved cognitive outcomes. +1 more finding
Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
-
2026-10-01
An explainable multimodal framework for exploring depression-associated speech representations in Alzheimer’s disease
16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv
Key finding: By comparing these unsupervised representations to a depression-labelled source corpus, one cluster demonstrated mathematical proximity (measured via cosine similarity in a shared latent space) to the source depression centroid. +2 more findings
Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →