Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,151–12,175 of 27,380 studies, newest first · page 487 of 1096.
January 2020 9
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2020-01-01
Development of Algorithmic Dementia Ascertainment for Racial/Ethnic Disparities Research in the US Health and Retirement Study
42/100 ✓ Peer-reviewed Disparities Epidemiology (Cambridge, Mass.)
Key finding: We believe these algorithms will be of immense value to dementia researchers interested in racial/ethnic disparities. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-01
Stressful Life Events and Racial Disparities in Cognition Among Middle-Aged and Older Adults
49/100 ✓ Peer-reviewed Disparities Journal of Alzheimer's disease : JAD
Key finding: Greater lifetime stress predicted poorer later-life cognition, and, in a small sample of African Americans, faster declines in a key domain of episodic memory. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-01
Association of Subclinical Hearing Loss With Cognitive Performance
64/100 ✓ Peer-reviewed Disparities JAMA otolaryngology-- head & neck surgery
Key finding: Among 6451 individuals, the mean (SD) age was 59.4 (6.1) years, and 3841 (59.5%) were women. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-01
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease
50/100 ✓ Peer-reviewed Getting a diagnosis Current neuropharmacology
Key finding: Biomarkers, brain-imaging, and theranostics, along with artificial intelligence, are understood to be the future of the management of Alzheimer's.
Full summary, score breakdown and related studies → Original source
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2020-01-01
Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer's Disease, and Dementia: From FINGER to World-Wide FINGERS
56/100 ✓ Peer-reviewed Prevention and risk The journal of prevention of Alzheimer's disease
Key finding: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is the first large, long-term RCT to demonstrate that a multidomain lifestyle-based intervention ameliorating vascular and lifestyle-related risk factors can preserve cognitive functioning and reduce the risk of cognitive decline among older adults at increased risk of dementia.
Full summary, score breakdown and related studies → Original source
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2020-01-01
Danggui-Shaoyao-San for dementia: A PRISMA-compliant systematic review and meta-analysis
60/100 ✓ Peer-reviewed Treatments Medicine
Key finding: These estimates suggest that DSS provides clinically important reductions in symptoms of AD and VD and can be a promising anti-dementia drug candidate. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-01
Neurofilament Light Predicts Decline in Attention but Not Episodic Memory in Preclinical Alzheimer's Disease
45/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: These findings suggest that NfL can be used to monitor cognitive decline in aging and Alzheimer's disease and that an attentional control composite may be a better outcome for tracking general neurodegenerative effects on cognition. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-01
Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study
58/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD
Key finding: Accounting for educationalfactors, vascular factors, and Aβ burden diminished, but did not eliminate, racial differences in PACC5 performance longitudinally. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-01-01
Consideration of Sex Differences in the Measurement and Interpretation of Alzheimer Disease-Related Biofluid-Based Biomarkers
41/100 ✓ Peer-reviewed Biomarkers The journal of applied laboratory medicine
Key finding: The development of cerebrospinal fluid and blood-based biomarkers for Alzheimer disease (AD) and related disorders is rapidly progressing. +4 more findings
Full summary, score breakdown and related studies → Original source
December 2019 16
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2019-12-31
Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
41/100 ✓ Peer-reviewed Prevention trials Antioxidants (Basel, Switzerland)
Key finding: These foods are especially rich in polyphenols, being the most relevant in the MD hydroxytyrosol (HT) and their derivatives present in EVOO, which have demonstrated a wide array of biological activities. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-12-30
Objective subtle cognitive difficulties predict future amyloid accumulation and neurodegeneration
50/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: Relative to CN participants, Obj-SCD was associated with faster amyloid accumulation and selective vulnerability of entorhinal cortical thinning, whereas MCI was associated with faster entorhinal and hippocampal atrophy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-30
Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
38/100 ✓ Peer-reviewed Inflammation and the immune system Neuron
Key finding: We find that reduced GCase activity does not result in aggregation of α-synuclein.
Full summary, score breakdown and related studies → Original source
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2019-12-30
White matter hyperintensities and CSF Alzheimer disease biomarkers in preclinical Alzheimer disease
65/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: These results suggest that WMH primarily affect the risk of progression when CSF measures of neurodegeneration or neuronal injury (as reflected by t-tau) are low. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-29
Beneficial effect of computer-based multidomain cognitive training in patients with mild cognitive impairment
66/100 ✓ Peer-reviewed Prevention trials Applied neuropsychology. Adult
Key finding: Analysis of the baseline versus endpoint performance of each group demonstrated that in the control group delayed memory and executive function had deteriorated over the observation period of 15 weeks, while improvement was observed in the training group's performance on delayed memory, word recognition, Boston Naming Test (BNT), Clock Drawing Test (CDT), Semantic Fluency (SF), Trail Making Test-A (TMT-A) and Trail Making Test-B (TMT-B). +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-12-28
Multi-modal latent space inducing ensemble SVM classifier for early dementia diagnosis with neuroimaging data
47/100 ✓ Peer-reviewed Long-term cohort studies Medical image analysis
Key finding: However, there are at least four common issues associated with the existing fusion methods. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-28
Prevalence of sarcopenia as a comorbid disease: A systematic review and meta-analysis
65/100 ✓ Peer-reviewed Risk factors Experimental gerontology
Key finding: Sarcopenia is highly prevalent in individuals with CVD, dementia, diabetes mellitus and respiratory disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-12-28
Unsupervised machine learning for the discovery of latent disease clusters and patient subgroups using electronic health records
43/100 ✓ Peer-reviewed Digital health tools Journal of biomedical informatics
Key finding: The experimental results show that the proposed PDM could effectively identify distinguished disease clusters based on the latent patterns hidden in the EHR data by alleviating the impact of age and sex, and that LDA could stratify patients into differentiable subgroups with larger p-values than PDM. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-12-28
Differentiating dementia disease subtypes with gait analysis: feasibility of wearable sensors?
51/100 ✓ Peer-reviewed Digital health tools Gait & posture
Key finding: This study found that a wearable device can be used to differentiate dementia disease subtypes. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-27
Modified Glutamatergic Postsynapse in Neurodegenerative Disorders
41/100 ✓ Peer-reviewed Disease mechanisms Neuroscience
Key finding: The postsynaptic density (PSD) is a complex subcellular domain important for postsynaptic signaling, function, and plasticity. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-27
Hospice Utilization in the United States: A Prospective Cohort Study Comparing Cancer and Noncancer Deaths
67/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: Extrapolating results to the US population, we estimate that annually nearly a million individuals who are likely eligible for hospice die without its services. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-27
Diagnostic accuracy of the Montreal Cognitive Assessment (MoCA) for cognitive screening in old age psychiatry: Determining cutoff scores in clinical practice. Avoiding spectrum bias caused by healthy controls
65/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry
Key finding: The Montreal Cognitive Assessment (MoCA) is an increasingly used screening tool for cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-26
Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts
38/100 ✓ Peer-reviewed Risk factors Free radical biology & medicine
Key finding: Traffic-related air pollution particulate matter (TRAP-PM) is associated with increased risk of Alzheimer Disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-12-26
Diabetes as a risk factor for Alzheimer's disease in the Middle East and its shared pathological mediators
41/100 ✓ Peer-reviewed Disease mechanisms Saudi journal of biological sciences
Key finding: A growing body of research indicates that AD is linked to diabetes mellitus (DM) and suggests that impaired insulin signaling acts as a crucial risk factor in determining the progression of this devastating disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-26
Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis
68/100 ✓ Peer-reviewed Prevention and risk Journal of neurology, neurosurgery, and psychiatry
Key finding: Sleep management might serve as a promising target for dementia prevention. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-12-26
A Phase I Study to Assess the Effect of Speed of Injection on Pain, Tolerability, and Pharmacokinetics After High-volume Subcutaneous Administration of Gantenerumab in Healthy Volunteers
57/100 ✓ Peer-reviewed Treatments Clinical therapeutics
Key finding: Our study compared the pain associated with 5- and 15-s subcutaneous injections of gantenerumab and evaluated the tolerability and pharmacokinetic properties of subcutaneous gantenerumab. +3 more findings
Full summary, score breakdown and related studies → Original source
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