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Association Between Relevant Co-Morbidities and Dementia With Atrial Fibrillation-A National Study
Per Wändell, Axel C Carlsson, Xinjun Li, Jan Sundquist, Kristina Sundquist. Archives of medical research, 2019-05-31
Topic: Drug trials: efficacy and safety
Totally 30,332 patients (5.6%) were diagnosed with dementia during the follow-up, with 14,097 men (4.9%) and 16,235 women (6.5%). After adjustments (HRs; 95% CI), hypertension was associated with lower risk of incident dementia (all types) in men (0.79; 0.76-0.82) and women (0.77; 0.74-0.79). Higher risk of dementia was seen in patients with stroke, diabetes, depression and anxiety. Lower risks of dementia were also seen in AF patients with concomitant coronary heart disease and congestive heart failure. The findings regarding incident dementia need to be interpreted with great caution, owing to possible "survival bias" or reversed causation. However, the lower associated risks of dementia associated with hypertension could possibly be explained by protective effects of certain antihypertensive drugs.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wändell, P., Carlsson, A. C., Li, X., Sundquist, J., & Sundquist, K. (2019). Association Between Relevant Co-Morbidities and Dementia With Atrial Fibrillation-A National Study. Archives of medical research. https://doi.org/10.1016/j.arcmed.2019.05.007
Vancouver
Wändell P, Carlsson AC, Li X, Sundquist J, Sundquist K. Association Between Relevant Co-Morbidities and Dementia With Atrial Fibrillation-A National Study. Archives of medical research. 2019. doi:10.1016/j.arcmed.2019.05.007. PMID: 31349951.
BibTeX
@article{wandell2019-31349951,
author = {Wändell, Per and Carlsson, Axel C and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina},
title = {{Association Between Relevant Co-Morbidities and Dementia With Atrial Fibrillation-A National Study}},
journal = {Archives of medical research},
year = {2019},
doi = {10.1016/j.arcmed.2019.05.007},
pmid = {31349951},
url = {https://doi.org/10.1016/j.arcmed.2019.05.007}
}
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Key findings
- Totally 30,332 patients (5.6%) were diagnosed with dementia during the follow-up, with 14,097 men (4.9%) and 16,235 women (6.5%).
- After adjustments (HRs; 95% CI), hypertension was associated with lower risk of incident dementia (all types) in men (0.79; 0.76-0.82) and women (0.77; 0.74-0.79).
- Higher risk of dementia was seen in patients with stroke, diabetes, depression and anxiety.
- Lower risks of dementia were also seen in AF patients with concomitant coronary heart disease and congestive heart failure.
- The findings regarding incident dementia need to be interpreted with great caution, owing to possible "survival bias" or reversed causation.
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Study details
- Participants537,513
- Effect size5.6%; 4.9%; 6.5%
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 31 of the 56 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of medical research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 4 / 4 | 537,513 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31349951) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 31 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 31 of the 56 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
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