Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 25,226–25,250 of 27,380 studies, newest first · page 1010 of 1096.
March 2001 9
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2001-03-01
MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL
54/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: Temporal pole hyperintensity is a radiologic marker of CADASIL.
Full summary, score breakdown and related studies → Original source
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2001-03-01
Cognitive impairment in motor neuron disease with bulbar onset
35/100 ✓ Peer-reviewed Digital health tools Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
Key finding: This study adds further arguments for a cognitive impairment in MND/ALS. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-03-01
A randomized controlled trial of the effects of multi-sensory stimulation (MSS) for people with dementia
57/100 ✓ Peer-reviewed Digital health tools The British journal of clinical psychology
Key finding: Both MSS and Activity sessions appear to be effective and appropriate therapies for people with dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-03-01
Hormone replacement therapy and cognition: systematic review and meta-analysis
68/100 ✓ Peer-reviewed How common it is JAMA
Key finding: In women with menopausal symptoms, HRT may have specific cognitive effects, and future studies should target these effects. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-03-01
Risk of dementia in Parkinson's disease: a community-based, prospective study
57/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: Forty-three patients with PD were demented at follow-up evaluation, equivalent to an incidence rate of 95.3 per 1,000 person-years (95% CI, 68.2 to 122.0). +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-03-01
Physical activity and risk of cognitive impairment and dementia in elderly persons
64/100 ✓ Peer-reviewed Prevention and risk Archives of neurology
Key finding: Regular physical activity could represent an important and potent protective factor for cognitive decline and dementia in elderly persons. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-03-01
Response of patients with Alzheimer disease to rivastigmine treatment is predicted by the rate of disease progression
62/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: Rivastigmine administration during open-label extension therapy benefited patients who had progressed slowly and those who had progressed rapidly during initial double-blind placebo treatment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-03-01
Reproductive period and risk of dementia in postmenopausal women
61/100 ✓ Peer-reviewed Genetics JAMA
Key finding: During 21 046 person-years of follow-up (median follow-up, 6.3 years), 199 women developed dementia, including 159 who developed AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-03-01
Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice
56/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Cerebrospinal fluid tau and CSF-Abeta42 have so far been studied in research settings, under conditions providing data on the optimal performance.
Full summary, score breakdown and related studies → Original source
February 2001 16
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2001-02-15
β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis
40/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroscience
Key finding: Reactive microglia associated with the beta-amyloid plaques in Alzheimer's disease (AD) brains initiate a sequence of inflammatory events integral to the disease process. +2 more findings
Full summary, score breakdown and related studies → Original source
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2001-02-01
Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment
66/100 ✓ Peer-reviewed Long-term cohort studies Annals of neurology
Key finding: Individuals with mild cognitive impairment (63.5%; p < 0.0003) and mild or moderate Alzheimer's disease (46.06%; p < 0.0017) displayed significant losses of layer II entorhinal cortex neurons relative to those with no cognitive impairment but not relative to each other (p > 0.33). +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-02-01
Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana
71/100 ✓ Peer-reviewed Disparities JAMA
Key finding: This is the first report of incidence rate differences for dementia and AD in studies of 2 populations from nonindustrialized and industrialized countries using identical methods and the same group of investigators in both sites. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-02-01
High short-term mortality in hospitalized patients with advanced dementia: lack of benefit of tube feeding
47/100 ✓ Peer-reviewed End-of-life care Archives of internal medicine
Key finding: In this cohort of hospitalized patients with advanced dementia, risk of receiving a new feeding tube is high, associated with African American ethnicity, and prior residence in a nursing home, and has no measurable influence on survival. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-02-01
Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's disease
36/100 ✓ Peer-reviewed Treatments Biological psychiatry
Key finding: The allosterically potentiating ligand action, which is not necessarily associated with cholinesterase inhibition, has been demonstrated by whole-cell patch-clamp recordings to occur in natural murine and human neurons and in murine and human cell lines expressing various subtypes of neuronal nicotinic acetylcholine receptors.
Full summary, score breakdown and related studies → Original source
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2001-02-01
Proapoptotic effects of tau cleavage product generated by caspase-3
36/100 ✓ Peer-reviewed Drug development Neurobiology of disease
Key finding: Overexpression of DeltaTau in SK-N-BE2(C) cells significantly increased the incidence of cell death. +1 more finding
Full summary, score breakdown and related studies → Original source
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2001-02-01
Perspectives on care at the close of life. Serving patients who may die soon and their families: the role of hospice and other services
47/100 ✓ Peer-reviewed End-of-life care JAMA
Key finding: Function and symptoms for those living with serious chronic illness at the end of life generally follow 1 of 3 trajectories: (a) a short period of obvious decline at the end, which is typical of cancer; (b) long-term disability, with periodic exacerbations, and unpredictable timing of death, which characterizes dying with chronic organ system failures; or (c) self-care deficits and a slowly dwindling course to death, which usually results from frailty or dementia.
Full summary, score breakdown and related studies → Original source
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2001-02-01
Progression of dysarthria and dysphagia in postmortem-confirmed parkinsonian disorders
44/100 ✓ Peer-reviewed Clinical safety Archives of neurology
Key finding: Latency to onset of dysarthria and dysphagia clearly differentiated PD from the APDs, but did not help distinguish different APDs.
Full summary, score breakdown and related studies → Original source
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2001-02-01
Infection Control in Africa South of the Sahara
30/100 ✓ Peer-reviewed Health systems and care delivery Infection Control and Hospital Epidemiology
Full summary, score breakdown and related studies → Original source
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2001-02-01
Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study
49/100 ✓ Peer-reviewed Long-term cohort studies Atherosclerosis
Key finding: Apolipoprotein (apo) E is a constituent of lipoproteins with considerable variation due to cysteine-arginine exchanges. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-02-01
Semantic memory is impaired in both dementia with Lewy bodies and dementia of Alzheimer's type: a comparative neuropsychological study and literature review
41/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: Both DLB and DAT groups exhibited impaired performance across the range of tasks designed to assess semantic memory. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-02-01
The Mini-Cog: receiver operating characteristics with expert and naïve raters
46/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry
Key finding: As elderly populations grow, dementia detection in the community is increasingly needed. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-02-01
Perception, attention, and working memory are disproportionately impaired in dementia with Lewy bodies compared with Alzheimer's disease
46/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: Both patient groups performed equally poorly on tests of episodic and semantic memory with the exception of immediate and delayed story recall, which was worse in the AD group. +3 more findings
Full summary, score breakdown and related studies → Original source
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2001-02-01
Alzheimer dementia in Down's syndrome: the relevance of cognitive ability
35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of intellectual disability research : JIDR
Key finding: More years of education have been found to be associated with a lower rate of Alzheimer disease (AD) in individuals without intellectual disability. +4 more findings
Full summary, score breakdown and related studies → Original source
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2001-02-01
Cerebral amyloidosis, amyloid angiopathy, and their relationship to stroke and dementia
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of Alzheimer's disease : JAD
Key finding: It is a feature commonly associated with normal aging, Alzheimer disease (AD), Down syndrome (DS), and Sporadic Cerebral Amyloid Angiopathy.
Full summary, score breakdown and related studies → Original source
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2001-02-01
Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Naunyn-Schmiedeberg's archives of pharmacology
Key finding: In DS, no significant differences from control values could be observed in any of the brain regions. +3 more findings
Full summary, score breakdown and related studies → Original source
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