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The use of zebrafish (Danio rerio) as biomedical models
Tsegay Teame, Zhen Zhang, Chao Ran, Hongling Zhang, Yalin Yang, Qianwen Ding, Minxu Xie, Chenchen Gao et al.. Animal Frontiers, 2019-06-25
Topic: Gut, metabolism and diet
Animal models provide consistency and validity of research results from in vitro studies or studies with rodents. As shown in Figure 1, the number of publications per year on zebrafish as a model for biomedical research has been significantly increasing in recent years. In the laboratory, to get reasonable research results, zebrafish should receive the appropriate type and level of dietary nutrients. Most of the time researchers use different commercial diets for zebrafish, but several commercial diets have undefined nutritional composition and may have an effect on experimental results (Gonzales and Law, 2013). In research studies, it is important to use a standard diet with adequate nutritional composition and known ingredients, which promote optimum growth and physiological status of the fish and to minimize the contribution of unintended nutritional effects on experimental results. The following diet formulas (Tables 1 and 2) were developed in our laboratory and give consistent experimental results with zebrafish. Disturbance of the normal process of converting food to energy in the cell results in different metabolic disorders. A report from World Health Organization indicated that, of the metabolism-related human diseases, cardiovascular disease is currently the most predominant fatal disease (Lozano et al., 2012). The between and type 2 diabetes was developed by et al. and that young zebrafish to mo developed than zebrafish with increasing of The concentration of homeostasis organs can be increased by zebrafish embryos in a et al. showed that of adult zebrafish in a for hr increase blood up to 400 The transgenic models of insulin established by et al. were skeletal muscle insulin by transgenic expression of a in skeletal In the model, insulin was of the insulin gene using CRISPR/Cas9 et al., 2015). These results that zebrafish are a suitable model to study human disease. et al. also developed a zebrafish model for by human insulin in zebrafish These studies of the type in research results of et al. showed that mutant zebrafish with a in insulin a and genes when fed a diet showed growth increased and fatty liver development, which are similar to the human disease. The changes showed by zebrafish fed a high level of are very similar with the shown in human and 2012). of a diet is also important for the study of et al., et al. lipid and metabolism using the zebrafish embryo metabolism stages and that of fatty the system was dependent on production in t
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APA 7th
Teame, T., Zhang, Z., Ran, C., Zhang, H., Yang, Y., Ding, Q., et al. (2019). The use of zebrafish (Danio rerio) as biomedical models. Animal Frontiers. https://doi.org/10.1093/af/vfz020
Vancouver
Teame T, Zhang Z, Ran C, Zhang H, Yang Y, Ding Q, et al. The use of zebrafish (Danio rerio) as biomedical models. Animal Frontiers. 2019. doi:10.1093/af/vfz020. PMID: 32002264.
BibTeX
@article{teame2019-32002264,
author = {Teame, Tsegay and Zhang, Zhen and Ran, Chao and Zhang, Hongling and Yang, Yalin and Ding, Qianwen and Xie, Minxu and Gao, Chenchen and others},
title = {{The use of zebrafish (Danio rerio) as biomedical models}},
journal = {Animal Frontiers},
year = {2019},
doi = {10.1093/af/vfz020},
pmid = {32002264},
url = {https://doi.org/10.1093/af/vfz020}
}
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Key findings
- Animal models provide consistency and validity of research results from in vitro studies or studies with rodents.
- As shown in Figure 1, the number of publications per year on zebrafish as a model for biomedical research has been significantly increasing in recent years.
- In the laboratory, to get reasonable research results, zebrafish should receive the appropriate type and level of dietary nutrients.
- Most of the time researchers use different commercial diets for zebrafish, but several commercial diets have undefined nutritional composition and may have an effect on experimental results (Gonzales and Law, 2013).
- In research studies, it is important to use a standard diet with adequate nutritional composition and known ingredients, which promote optimum growth and physiological status of the fish and to minimize the contribution of unintended nutritional effects on experimental results.
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 24 of the 58 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Animal Frontiers) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “zebrafish”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32002264) |
| Free to read | 2 / 2 | Free to read |
| Points | 24 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 24 of the 58 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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