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Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner
Jaitin DA, Adlung L, Thaiss CA, Weiner A, Li B, Descamps H, Lundgren P, Bleriot C et al.. Cell, 2019-06-27
Topic: Brain proteins, microglia and lab models
Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the molecular regulators that drive adipose tissue immune cell remodeling during obesity remain largely unknown. Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity. We describe a novel and conserved Trem2 + lipid-associated macrophage (LAM) subset and identify markers, spatial localization, origin, and functional pathways associated with these cells.
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APA 7th
Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., et al. (2019). Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner. Cell. https://doi.org/10.1016/j.cell.2019.05.054
Vancouver
Jaitin DA, Adlung L, Thaiss CA, Weiner A, Li B, Descamps H, et al. Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner. Cell. 2019. doi:10.1016/j.cell.2019.05.054. PMID: 31257031.
BibTeX
@article{jaitin2019-31257031,
author = {Jaitin, D. A. and Adlung, L. and Thaiss, C. A. and Weiner, A. and Li, B. and Descamps, H. and Lundgren, P. and Bleriot, C. and others},
title = {{Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner}},
journal = {Cell},
year = {2019},
doi = {10.1016/j.cell.2019.05.054},
pmid = {31257031},
url = {https://doi.org/10.1016/j.cell.2019.05.054}
}
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Key findings
- Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity.
- We describe a novel and conserved Trem2 + lipid-associated macrophage (LAM) subset and identify markers, spatial localization, origin, and functional pathways associated with these cells.
- Genetic ablation of Trem2 in mice globally inhibits the downstream molecular LAM program, leading to adipocyte hypertrophy as well as systemic hypercholesterolemia, body fat accumulation, and glucose intolerance.
- These findings identify Trem2 signaling as a major pathway by which macrophages respond to loss of tissue-level lipid homeostasis, highlighting Trem2 as a key sensor of metabolic pathologies across multiple tissues and a potential therapeutic target in metabolic diseases.
Why it matters
This study describes a Trem2+ lipid-associated macrophage subset in fat tissue of mice and humans during obesity. It concerns metabolic disease and does not test any treatment, cure or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 61/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cell) |
| Journal's citation record | 4 / 4 | Cell: journal h-index 1,220 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,358 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 150.9 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 6 / 6 | Cited 73.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 49 other studies in this library |
| Still being cited | 4 / 4 | Cited 692 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Ido Amit: h-index 114 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 10 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31257031) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 61 / 100 | — |
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