Newest studies

The transition to retirement and dementia risk: An application of sequence analysis

16/100 ⚠ Preprint — not yet peer-reviewed Long-term cohort studies medRxiv

Key finding: Retirement timing alone showed limited association with later-life dementia risk, whereas sustained part-time employment and disability-related trajectories were more strongly associated with dementia risk. +4 more findings

• Risk Factors

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Spermine inhibits ferroptosis in vascular dementia rats by intervening Nrf2/SLC7A11/GPX4 expression in chondriosome

16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions Research Square

Key finding: Spermine exerts neuroprotective effects in VaD by inhibiting TRPM2-mediated oxidative stress and activating the Nrf2/SLC7A11/GPX4 pathway, thereby suppressing ferroptosis. +2 more findings

• Other Dementias
• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Carbonic anhydrase inhibition rescues heart function in the Tg2576 Alzheimer’s mouse model by ameliorating cardiac amyloid-β pathology and neurotrophic-signaling impairment

16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions bioRxiv

Key finding: We have recently shown that Aβ aggregates disrupt neuro-signaling and deplete neurotrophic factors (particularly BDNF) in the heart of AD mouse models and human subjects. +4 more findings

• Brain Biology
• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Navigating Life After Dementia Diagnosis: Questions, Challenges, and Support Needs Among Dementia Dyads

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: Dementia dyads experience substantial informational, emotional, and practical support needs in the early stages of MCI and AD/ADRD. +2 more findings

• Diagnosis
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Seasonally Normalized Vitamin D Status and Long-Term Mortality and Multisystem Disease Risk in the UK Biobank

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: Seasonally normalized 25(OH)D identifies a reproducible state of systemic vulnerability while reducing exposure misclassification caused by calendar timing of measurement. +4 more findings

• Risk Factors
• Lifestyle

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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MTHFR*677C>T produces distinct prodromal disease signatures in a mouse model of late-onset Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics Research Square

Key finding: These data further support the use of the LOAD2.Mthfr 677C>T mouse model to study aspects of ADRD such as cerebrovascular compromise. +1 more finding

• Genetics
• Brain Biology
• Early Stage

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Locus coeruleus intensity as a marker of early-stage Alzheimer’s disease: associations with plasma pTau 217 and memory

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv

Key finding: These findings support MRI-derived LC intensity as a marker of early AD-related processes and suggest that LC intensity may provide complementary information not captured by plasma pTau 217 alone. +3 more findings

• Biomarkers
• Brain Scans
• Early Stage

Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Cross-Tissue Inflammatory Convergence Supports a Putative Muscle–Brain Axis in Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment bioRxiv

Key finding: Aging muscle showed increased inflammatory, extracellular-matrix, and stromal communication programs. +2 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood–brain barrier disruption in Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions bioRxiv

Key finding: Analysis of human single-nucleus transcriptomic data further demonstrated that vascular expression of MFSD2A declined during transition from mild cognitive impairment to established AD. +1 more finding

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The Gut–Liver–Brain Axis in Neurodegeneration: Unraveling Metabolic–Immune Crosstalk from Peripheral Sensing to Central Vulnerability

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk Preprints.org

Key finding: However, increasing evidence indicates that systemic metabolic dysfunction, chronic inflammation, intestinal dysbiosis, hepatic abnormalities, and barrier impairment may substantially influence disease susceptibility and progression.

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Vibrotactile transcutaneous auricular vagus nerve stimulation (taVNS) during working memory: convergent electrophysiological evidence for cortical efficiency

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

Key finding: Our results converge on the conclusion that vtaVNS does not uniformly amplify cortical responses to external stimuli. +4 more findings

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The Somnogenesis System: A Proposed Biological System for Psychiatry

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Preprints.org

Key finding: Each hub carries an established, distinct function, and the evidence suggests these functions operate as a dependency chain rather than as independent, parallel contributions, consistent with the proposed existence of a genuine biological system rather than three regions coincidentally active at the same time. +4 more findings

• Other Dementias

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Plasma metabolomic profiling of frailty in older adults at risk of dementia

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: Frailty index was associated with carboxylic acids and derivatives, fatty acyls and organooxygen compounds across multiple clusters, and a large number of lipids were linked to frailty score, potentially implicating dysregulation of energy metabolism in the pathophysiology of frailty and forming a panel of predictive biomarkers of at risk patients. +2 more findings

• Biomarkers
• Risk Factors

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Neuroprotective Role of Vitamin D Against LPS-Induced Cognitive Deficits in Rats: Targeting Hippocampal PERK-ATF4-CHOP-Mediated ER Stress and Calcium Dyshomeostasis

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

Key finding: In conclusion, VitD exerted a multifaceted protective effect against LPS-induced cognitive dysfunction, suggesting VitD as a promising approach for mitigating AD-related cognitive decline, potentially involving attenuation of hippocampal neuroinflammation and ER stress, with modulation of the PERK-ATF4-CHOP pathway, and alleviation of Ca²⁺ dysregulation.

• Lifestyle

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Forecasting Alzheimer’s disease progression using non-imaging clinical features and XGBoost

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: Machine learning (ML) methods have shown promise in modeling clinical trajectories associated with neurodegenerative disorders such as Alzheimer’s disease (AD). +2 more findings

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A Machine Learning-Based Framework for differential screening of Neurodegenerative Dementias using routine clinical data

16/100 ⚠ Preprint — not yet peer-reviewed Getting a diagnosis Research Square

Key finding: Symptom chronology emerged as a robust diagnostic discriminator, underscoring the clinical value of temporal disease trajectories. +2 more findings

• Diagnosis
• Other Dementias
• Digital Tools

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Perceived Barriers for Advance Care Planning Among People with Dementia and Family Caregivers: A Systematic Review of Qualitative Studies

16/100 ⚠ Preprint — not yet peer-reviewed End-of-life care Preprints.org

Key finding: Two analytical themes were identified: (1) challenges in preserving the person's voice throughout the dementia trajectory, reflecting a shift toward caregiver-mediated decision-making, assumptions about capacity, and delayed ACP initiation; and (2) challenges in maintaining continuity of expressed values and preferences over time, reflecting uncertainty about future care needs and the limitations of one-time ACP conversations. +4 more findings

• Caregiving
• End-of-Life Care

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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TLR7-mediated autoimmunity targets Robo3 to drive astrogliosis in frontotemporal dementia

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Research Square

Key finding: Together, these results offer critical insights into how TLR7-mediated autoimmune dysfunction targets Robo3 to drive neuroinflammation and neurodegeneration in FTD.

• Brain Biology
• Other Dementias

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Human multiscale transcriptomics identifies the NLRP3 inflammasome as a convergent druggable target in Alzheimer’s disease: validation with dimethyl itaconate in 5xFAD mice

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology Research Square

Key finding: Meta-analysis revealed significant upregulation of inflammasome-related genes, including GSDMD (log₂FC = 0.72; pooled p = 5.4 × 10 -5 ), PYCARD , and CASP1 ; GSDMD expression was highest at Braak stage VI, consistent with progressive engagement of the pyroptotic effector arm in advanced AD. +3 more findings

• Brain Biology

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Brain region- and solubility-dependent proteomic signatures of neurofibrillary tangle pathology in Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology medRxiv

Key finding: A total of 5,573 protein groups were identified, including 452 differentially expressed proteins (DEPs), 183 bidirectional expression proteins (BEPs), and 693 differentially soluble proteins (DSPs) associated with NFT pathology. +1 more finding

• Brain Biology

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Generalizing Amyloid β Pathology from Postmortem Human Brains with Vision Foundation Models for Lesion Quantification

16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions medRxiv

Key finding: The ViTamyloid classifier achieved strong feature-separation metrics, yielding area under the receiver operating characteristic curve (AUROC) and precision-recall curve (AUPRC) values of 0.994/0.958 for CCP, 0.989/0.945 for CGP, 0.992/0.977 for CAA Type 1, and 0.997/0.978 for CAA Type 2. +3 more findings

• Brain Biology

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Triple-Omics Analysis Unveiled the Neuroprotective Mechanisms of Akkermansia muciniphila in an Environmental Exposure-Linked Mouse Model of Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: These findings identify restoration of hippocampal transcript fate and splice-isoform selection as a mechanism potentially underlying A. muciniphila -mediated protection against Cd neurotoxicity, and establish post-transcriptional RNA regulation as a gut-brain target for mitigating environmentally driven neurotoxicity. +2 more findings

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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PFKFB3 inhibition restores β-cell responsiveness to acetylcholine in a 3xTg-AD pancreatic tissue-slice model

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors bioRxiv

Key finding: Compared to wild-type controls, β-cells showed weaker glucose-stimulated and acetylcholine-potentiated Ca 2+ activity, accompanied by increased nuclear PFKFB3 positivity in insulin-defined islet-cell populations, used here as a PFKFB3-associated stress-state marker.

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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A Multiethnic Analysis of DNA Methylation Reveals Links Between Alzheimer’s Disease and Metabolic Comorbidities

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: The two sites associated with interactions between AD and a metabolic condition could explain the influence that those conditions have on the risk for AD and are prime candidates for future study. +2 more findings

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Analytical performance of a delayed-centrifugation blood collection tube for remote blood biomarker assessment

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: The NULISA assay demonstrated excellent technical reproducibility (intra- and inter-plate coefficients of variation [CVs] <10%). +3 more findings

• Biomarkers

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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