Newest studies

Amyotrophic lateral sclerosis: a clinical review

55/100 ✓ Peer-reviewed Getting a diagnosis European journal of neurology

Key finding: To date, more than 20 genes have been associated with ALS.

• Other Dementias
• Genetics

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Older molecular brain age in severe mental illness

45/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: Psychiatric disorders are associated with accelerated aging and enhanced risk for neurodegenerative disorders. +4 more findings

• Genetics

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Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

41/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: Our findings identify CatD as the principal intracellular Aβ-degrading protease identified to date, one that regulates Aβ42/40 ratios via differential degradation of Aβ42 vs. Aβ40. +2 more findings

• Genetics
• Brain Biology

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Association between palliative care and healthcare outcomes among adults with terminal non-cancer illness: population based matched cohort study

74/100 ✓ Peer-reviewed End-of-life care BMJ (Clinical research ed.)

Key finding: These findings highlight the potential benefits of palliative care in some non-cancer illnesses. +4 more findings

• End-of-Life Care
• Care Services

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β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline

48/100 ✓ Peer-reviewed Digital health tools Communications biology

Key finding: Clinical trials focusing on therapeutic candidates that modify β-amyloid (Aβ) have repeatedly failed to treat Alzheimer's disease (AD), suggesting that Aβ may not be the optimal target for treating AD. +1 more finding

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Longitudinal ComBat: A method for harmonizing longitudinal multi-scanner imaging data

60/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: We propose a method for harmonizing longitudinal multi-scanner imaging data based on ComBat, a method originally developed for genomics and later adapted to cross-sectional neuroimaging data. +4 more findings

• Brain Scans

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World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

61/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach.

• Prevention

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Neurovascular Inflammaging in Health and Disease

39/100 ✓ Peer-reviewed Inflammation and the immune system Cells

Key finding: Similarly, in age-related diseases of the central nervous system (CNS), inflammasome activation is a prominent moment, in which cells of the neurovascular unit occupy a significant position.

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Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease

39/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: A properly balanced diet contains a substantial amount of LC as well as essential amino acids and microelements taking part in endogenous carnitine synthesis. +4 more findings

• Lifestyle

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Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer's disease

39/100 ✓ Peer-reviewed Genetics Neurobiology of aging

Key finding: Our prior work showed that Aβ transit across the blood-brain-barrier was reduced by apoE4, compared to other apoE isoforms, due to elevated lipoprotein receptor shedding in brain endothelia. +4 more findings

• Genetics

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Spermidine intake is associated with cortical thickness and hippocampal volume in older adults

38/100 ✓ Peer-reviewed Prevention trials NeuroImage

Key finding: Previous research has demonstrated beneficial impact of spermidine intake on memory functions in both animal models and humans, suggesting that spermidine may be a preventive approach to delay age-related cognitive decline and possibly even Alzheimer's disease (AD). +4 more findings

• Brain Scans

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One-Stop Shop: 18F-Flortaucipir PET Differentiates Amyloid-Positive and -Negative Forms of Neurodegenerative Diseases

46/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Pattern expression strengths predicted amyloid status with a sensitivity of 0.94 and a specificity of 0.83. +4 more findings

• Brain Scans

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Omega-3 fatty acids increase OXPHOS energy for immune therapy of Alzheimer disease patients

39/100 ✓ Peer-reviewed Prevention and risk FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Key finding: Long-term studies of immunity to pathogenic amyloid-β (Aβ) in LOAD are lacking. +4 more findings

• Treatments
• Early Stage
• Lifestyle

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Metformin preferentially provides neuroprotection following cardiac ischemia/reperfusion in non-diabetic rats

41/100 ✓ Peer-reviewed Drug development Biochimica et biophysica acta. Molecular basis of disease

Key finding: In conclusion, metformin given during ischemia preferentially provides neuroprotection against brain mitochondrial dysfunction, apoptosis, microglial activation, and dendritic spine loss in an AMPK-independent manner following cardiac I/R injury.

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Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System

41/100 ✓ Peer-reviewed Vascular contributions Frontiers in molecular neuroscience

Key finding: Also, TrkB signaling, specifically the TrkB/PI3K/Akt (TrkB/phosphatidylinositol 3 kinase/protein kinase B) pathway promotes the activation and nuclear translocation of Nrf2, and thus, confers neuroprotection against OS. +4 more findings

• Brain Biology

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Decomposing Urban and Rural Disparities of Preventable ED Visits Among Patients With Alzheimer's Disease and Related Dementias: Evidence of the Availability of Health Care Resources

41/100 ✓ Peer-reviewed Risk factors The Journal of Rural Health

Key finding: Rural patients with ADRD had 1.23 higher adjusted odds (P < .001) of going to the ED for a preventable visit compared to urban counterparts. +4 more findings

• Health Equity

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Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project

53/100 ✓ Peer-reviewed Long-term cohort studies Biological psychiatry

Key finding: Thirty-three percent of LLD participants met ADNI criteria for mild cognitive impairment. +3 more findings

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Using machine learning to quantify structural MRI neurodegeneration patterns of Alzheimer's disease into dementia score: Independent validation on 8,834 images from ADNI, AIBL, OASIS, and MIRIAD databases

47/100 ✓ Peer-reviewed Digital health tools Human brain mapping

Key finding: Classification performance on stable versus progressive mild cognitive impairment (MCI) groups achieved an AUC of 0.81 for TTC of 6 months and 0.73 for TTC of up to 7 years, achieving state-of-the-art results.

• Brain Scans
• Digital Tools

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Japanese Clinical Practice Guideline for Diabetes 2019

71/100 ✓ Peer-reviewed Drug development Journal of Diabetes Investigation

Key finding: Of note, dramatic progress has been made in recent years in diabetes research and clinical practice, which includes approval of antidiabetic agents with novel mechanisms of action along with publication of clinical trial results with these drugs, and novel diagnostic and therapeutic devices, such as continuous glucose monitoring (CGM) and sensor augmented pumps (SAP). +4 more findings

• Clinical Trials
• Treatments
• Risk Factors

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Diesel Exhaust Extract Exposure Induces Neuronal Toxicity by Disrupting Autophagy

39/100 ✓ Peer-reviewed Risk factors Toxicological sciences : an official journal of the Society of Toxicology

Key finding: The vast majority of neurodegenerative disease cannot be attributed to genetic causes alone and as a result, there is significant interest in identifying environmental modifiers of disease risk. +2 more findings

• Treatments

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Early Cognitive Decline and its Impact on Spouse's Loneliness

50/100 ✓ Peer-reviewed Risk factors Research in human development

Key finding: Individual's loneliness was stable when their spouse's cognition remained normal, but increased with the spouse's TCIND. +3 more findings

• Lifestyle
• Caregiving

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Alzheimer's Disease in Patients with Obstructive Sleep Apnea Syndrome

39/100 ✓ Peer-reviewed Risk factors Tanaffos

Key finding: Serious OSAS and short sleep duration are associated with a high risk of developing dementia. +4 more findings

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Classification of Mild Cognitive Impairment from multi-domain features of resting-state EEG

39/100 ✓ Peer-reviewed Prevention trials Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Key finding: Firstly, we extracted the multi-domain (time, frequency and information theory) features from resting-state EEG signals before and after a cognitive task from 15 MCI groups and 15 age-matched healthy controls. +4 more findings

• Early Stage

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MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide

55/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

Key finding: Deep learning has emerged as a powerful approach to constructing imaging signatures of normal brain ageing as well as of various neuropathological processes associated with brain diseases. +4 more findings

• Brain Scans

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Recommended physical activity and all cause and cause specific mortality in US adults: prospective cohort study

69/100 ✓ Peer-reviewed Prevention trials BMJ (Clinical research ed.)

Key finding: Adults who engage in leisure time aerobic and muscle strengthening activities at levels recommended by the 2018 physical activity guidelines for Americans show greatly reduced risk of all cause and cause specific mortality. +2 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source