Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,201–15,225 of 27,380 studies, newest first · page 609 of 1096.
March 2017 25
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2017-03-28
Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study
64/100 ✓ Peer-reviewed Genetics PLoS medicine
Key finding: Secondary analysis suggested that this effect may be driven primarily by individuals who are negative for the established AD genetic risk factor, apolipoprotein E (APOE) ɛ4. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-28
Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C Study: A longitudinal, population-based prospective cohort study
67/100 ✓ Peer-reviewed Genetics PLoS medicine
Key finding: Fasting lipid fractions (triglycerides [TGs], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC]) were studied as continuous variables, and results are reported per SD increase of each lipid fraction. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-27
Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial
59/100 ✓ Peer-reviewed Prevention trials The Lancet Neurology
Key finding: There were no significant differences in 3-year cognitive decline between any of the three intervention groups and the placebo group. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-27
Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease
48/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging
Key finding: Particularly, Aβ plaque-associated microglia take on an "activated" morphology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-27
Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment
57/100 ✓ Peer-reviewed Mild cognitive impairment Biological psychiatry
Key finding: Plasma BACE1 activity is significantly increased in MCI converters and patients with probable AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-24
Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD
53/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: Ninety-five individuals from the Wisconsin Registry for Alzheimer's Prevention were included in these cross-sectional analyses. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-23
Aberrant iPSC-derived human astrocytes in Alzheimer's disease
41/100 ✓ Peer-reviewed Biomarkers Cell Death and Disease
Key finding: However, induced astrocytes derived from both SAD and FAD patients exhibit a pronounced pathological phenotype, with a significantly less complex morphological appearance, overall atrophic profiles and abnormal localisation of key functional astroglial markers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-03-23
NPTX2 and cognitive dysfunction in Alzheimer's Disease
45/100 ✓ Peer-reviewed Hippocampus size on brain scans eLife
Key finding: In a mouse model of AD amyloidosis, Nptx2 -/- results in reduced GluA4 expression, disrupted rhythmicity, and increased pyramidal neuron excitability. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-03-23
Patient Self-Defined Goals: Essentials of Person-Centered Care for Serious Illness
50/100 ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care
Key finding: Sixteen percent of the goals were complex and reflected a mix of medical and nonmedical domains, "multiple" goals. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-23
A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model
45/100 ✓ Peer-reviewed Biomarkers Behavioural brain research
Key finding: Since type 2 diabetes (T2DM) has been identified as a risk factor for AD, the incretins glucagon-like peptide 1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP), promising antidiabetic agents for the treatment of type 2 diabetes, have been tested in models of neurodegenerative disease including AD and achieved good results. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-22
Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition
57/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy
Key finding: MPP-Aβ might be one of the potential blood biomarkers for the prediction of PiB-PET positivity in the brain. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-03-22
Outcomes after diagnosis of mild cognitive impairment in a large autopsy series
56/100 ✓ Peer-reviewed Disease mechanisms Annals of neurology
Key finding: MCI diagnosis usually was associated with comorbid neuropathologies; less than one-quarter of MCI cases showed "pure" AD at autopsy.
Full summary, score breakdown and related studies → Original source
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2017-03-22
Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis
48/100 ✓ Peer-reviewed Inflammation and the immune system Journal of the neurological sciences
Key finding: Several genetic, environmental, and physiological factors, including inflammations and metabolic influences, are involved in the progression of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-22
Intracranial atherosclerosis and dementia: The Atherosclerosis Risk in Communities (ARIC) Study
59/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from the population-based Atherosclerosis Risk in Communities Study by a sampling strategy that allowed weighting back to the cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-22
Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials
65/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: These studies fundamentally deepen our understanding of AD progression and its underlying genetic basis, which in turn informs and improves clinical trial design. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-03-22
Metabolic network failures in Alzheimer's disease: A biochemical road map
56/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Metabolomics identified key disease-related metabolic changes and disease-progression-related changes.
Full summary, score breakdown and related studies → Original source
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2017-03-22
The prognosis of dementia with Lewy bodies
52/100 ✓ Peer-reviewed Caregiving The Lancet. Neurology
Key finding: Dementia with Lewy bodies is the second most common form of neurodegenerative dementia, yet scarce evidence is available about its prognosis and natural history, which are crucial to inform clinical practice and research. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-21
Feasibility of in vivo 18F-florbetaben PET/MR imaging of human carotid amyloid-β
39/100 ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging
Key finding: 18F-Florbetaben uptake was clearly visualized in the carotid arteries. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-21
Observed Hearing Loss and Incident Dementia in a Multiethnic Cohort
64/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society
Key finding: OHL was associated with greater risk of incident dementia in a multiethnic cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-21
On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows
35/100 ✓ Peer-reviewed Risk factors Genetic epidemiology
Key finding: Compared to existing analysis approaches for WGS data, that define the tested regions either by sliding or consecutive windows of fixed sizes along variants, a meaningful grouping of nearby variants into consecutive regions has the advantage that, compared to sliding window approaches, the number of tested regions is likely to be smaller. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-03-21
The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
45/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation
Key finding: Triggering receptor expressed on myeloid cells 2 (TREM2) and apolipoprotein E (APOE) are genetically linked to Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-21
Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study
76/100 ✓ Peer-reviewed Prevention and risk PLoS medicine
Key finding: We also determined the extent to which sex, educational attainment, and apolipoprotein E ε4 allele (APOE*4) carrier status were associated with decline. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-03-21
Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: A cross-sectional study
58/100 ✓ Peer-reviewed Prevention and risk PLoS medicine
Key finding: Cross-sectional associations support the view that enhancing cognitive reserve may benefit cognition, and maintenance of cognitive health may be supported by a healthy and active lifestyle, in later life. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-21
APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts
63/100 ✓ Peer-reviewed Genetics PLoS medicine
Key finding: Overall, cumulative incidence was uniformly higher in NACC than in the population-based cohorts. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-21
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
56/100 ✓ Peer-reviewed Genetics PLoS medicine
Key finding: Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. +4 more findings
Full summary, score breakdown and related studies → Original source
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