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38/100

✓ Peer-reviewed alzhub usefulness score 38 out of 100. Risk factors

Topic: Amyloid, tau and blood-test diagnosis

Social determinants of health, such as neighborhood disadvantage, have been linked to an increased risk of clinical dementia syndrome; however, their association with neuropathologically confirmed Alzheimer's disease (AD) remains unknown. This is a critical gap because US neighborhood disadvantage is measureable, potentially modifiable and can be targeted specifically for research recruitment and intervention. The objective of this study was to employ geoanalytic techniques to investigate the association between neighborhood disadvantage and neuropathologically confirmed AD cases in two Alzheimer's Disease Research Center (ADRC) brain banks. The study included all brain bank participants with an available non-institutional address at the time of death (N=434; Figure 1). Addresses were geocoded, then linked to a corresponding Area Deprivation Index (ADI) state ranking, a validated measure of US neighborhood disadvantage which incorporates poverty, education, housing, and employment indicators. All neuropathological data were collected via NACC methodologies, using neuritic and diffuse plaque presence on neuropathological exam to determine AD. Results were analyzed utilizing basic frequencies and multinomial logistic regression, adjusting for age and sex, comparing those residing in the most disadvantaged 20% of neighborhoods to those in the least disadvantaged 80% of neighborhoods-- a standard approach for neighborhood disadvantage studies. There was no significant difference in mean age or proportion of male participants between those in the most disadvantaged 20% of neighborhoods to those in the least disadvantaged 80% of neighborhoods. However, significant differences were found in amyloid plaque burden, whereby the more disadvantaged group had a higher proportion of both neuritic and diffuse plaques. (Table 1) As compared to those from the least disadvantaged neighborhoods, participants from the most disadvantaged neighborhoods had higher adjusted odds of neuropathologically confirmed AD (Adjusted OR=5.24, [95% CI: 1.12, 20.09], p=0.034).

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APA 7th

Larson, J. L., Rissman, R. A., Vilen, L. H., Melah, K. E., Loosen, J. A., Salamat, S. M., et al. (2019). P2‐435: NEIGHBORHOOD DISADVANTAGE IS ASSOCIATED WITH NEUROPATHOLOGICALLY CONFIRMED ALZHEIMER'S DISEASE. Alzheimer s & Dementia. https://doi.org/10.1016/j.jalz.2019.06.2842

Vancouver

Larson JL, Rissman RA, Vilen LH, Melah KE, Loosen JA, Salamat SM, et al. P2‐435: NEIGHBORHOOD DISADVANTAGE IS ASSOCIATED WITH NEUROPATHOLOGICALLY CONFIRMED ALZHEIMER'S DISEASE. Alzheimer s & Dementia. 2019. doi:10.1016/j.jalz.2019.06.2842.

BibTeX

@article{larson2019-f458b5ba,
  author  = {Larson, Jamie L. and Rissman, Robert A. and Vilen, Leigha H. and Melah, Kelsey E. and Loosen, Julia A. and Salamat, Shahriar M. and Roy, Subhojit and Asthana, Sanjay and others},
  title   = {{P2‐435: NEIGHBORHOOD DISADVANTAGE IS ASSOCIATED WITH NEUROPATHOLOGICALLY CONFIRMED ALZHEIMER'S DISEASE}},
  journal = {Alzheimer s \& Dementia},
  year    = {2019},
  doi     = {10.1016/j.jalz.2019.06.2842},
  url     = {https://doi.org/10.1016/j.jalz.2019.06.2842}
}

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Key findings

Social determinants of health, such as neighborhood disadvantage, have been linked to an increased risk of clinical dementia syndrome; however, their association with neuropathologically confirmed Alzheimer's disease (AD) remains unknown.
Results were analyzed utilizing basic frequencies and multinomial logistic regression, adjusting for age and sex, comparing those residing in the most disadvantaged 20% of neighborhoods to those in the least disadvantaged 80% of neighborhoods-- a standard approach for neighborhood disadvantage studies.
There was no significant difference in mean age or proportion of male participants between those in the most disadvantaged 20% of neighborhoods to those in the least disadvantaged 80% of neighborhoods.
However, significant differences were found in amyloid plaque burden, whereby the more disadvantaged group had a higher proportion of both neuritic and diffuse plaques.
(Table 1) As compared to those from the least disadvantaged neighborhoods, participants from the most disadvantaged neighborhoods had higher adjusted odds of neuropathologically confirmed AD (Adjusted OR=5.24, [95% CI: 1.12, 20.09], p=0.034).

Why it matters

This study examined whether neighborhood disadvantage is linked to neuropathologically confirmed Alzheimer's disease in 434 brain bank participants. It used the Area Deprivation Index, a measure incorporating poverty, education, housing and employment indicators, to compare those in the most disadvantaged 20% of neighborhoods to those in the least disadvantaged 80%.

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Study details

Participants434
Effect sizeOR=5.24
Evidence strengthLow

How this study scored 38/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2019 — within 10 year(s) of the newest study here
Sample size	2 / 4	434 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.1 citations a year over 9 year(s) since 2019
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Amy Kind: h-index 47 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California San Diego: institution h-index 1,852 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	1 / 2	Not in PubMed, but has a DOI
Free to read	0 / 2	Behind a paywall — scores zero
Total	38 / 100	—

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