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F4‐01‐05: RACIAL AND ETHNIC DIFFERENCES IN AMYLOID PET POSITIVITY IN THE IDEAS STUDY
Consuelo Hopkins Wilkins, Peggye Dilworth‐Anderson, Rachel A. Whitmer, Lucy Hanna, Constantine A. Gatsonis, Bruce E. Hillner, Barry Alan Siegel, María C. Carrillo et al.. Alzheimer s & Dementia, 2019-07-01
Topic: Amyloid, tau and blood-test diagnosis
Racial and ethnic differences in Alzheimer's disease (AD) and related dementias are well documented. Compared to Whites, Blacks/African Americans and Latinos/Hispanics have 50-100% higher rates of clinical AD, while Asians/Asian Americans have markedly lower rates. Progress toward better elucidating and addressing these disparities has been hampered by underrepresentation of minorities in clinical research, especially studies of neuroimaging, biomarkers and pharmacotherapies. Objective: The aim of this study was to compare rates of amyloid PET positivity and sociodemographic factors across racial and ethnic groups in a usual care setting. Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) was a pragmatic, single arm, multi-site study of Medicare beneficiaries with mild cognitive impairment (MCI) or dementia. Participants were required to meet Appropriate Use Criteria for amyloid PET imaging including: etiology of cognitive impairment was unknown, AD was a diagnostic consideration and knowledge of PET results was expected to change diagnosis and management. IDEAS enrolled participants at 595 U.S. sites between February 2016 and September 2017. For the analyses, racial/ethnic categories were based on data collected at enrollment sites. 10% of the 18,550 participants were racial/ethnic minorities including 639 Blacks/African Americans, 848 Latinos/Hispanics and 328 Asian/Asian Americans. Whites were more likely to have a positive amyloid PET (62.7% [95% CI 62-63%]) versus Blacks/African Americans (53.8% [50-58%]), Latinos/Hispanics (54.1% [51-57%]) and Asian/Asian Americans (45.1% [40-51%]). See table for results by diagnosis. Compared to Whites, all minority groups were more likely to: have been diagnosed with dementia (vs MCI) prior to PET scan; consent by proxy; have Medicare Advantage and have diabetes. Blacks/African Americans were more likely to have hypertension and live alone, while Latinos/Hispanics and Asian/Asian Americans were less likely to live alone.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wilkins, C. H., Dilworth‐Anderson, P., Whitmer, R. A., Hanna, L., Gatsonis, C. A., Hillner, B. E., et al. (2019). F4‐01‐05: RACIAL AND ETHNIC DIFFERENCES IN AMYLOID PET POSITIVITY IN THE IDEAS STUDY. Alzheimer s & Dementia. https://doi.org/10.1016/j.jalz.2019.06.4717
Vancouver
Wilkins CH, Dilworth‐Anderson P, Whitmer RA, Hanna L, Gatsonis CA, Hillner BE, et al. F4‐01‐05: RACIAL AND ETHNIC DIFFERENCES IN AMYLOID PET POSITIVITY IN THE IDEAS STUDY. Alzheimer s & Dementia. 2019. doi:10.1016/j.jalz.2019.06.4717.
BibTeX
@article{wilkins2019-107a9626,
author = {Wilkins, Consuelo Hopkins and Dilworth‐Anderson, Peggye and Whitmer, Rachel A. and Hanna, Lucy and Gatsonis, Constantine A. and Hillner, Bruce E. and Siegel, Barry Alan and Carrillo, María C. and others},
title = {{F4‐01‐05: RACIAL AND ETHNIC DIFFERENCES IN AMYLOID PET POSITIVITY IN THE IDEAS STUDY}},
journal = {Alzheimer s \& Dementia},
year = {2019},
doi = {10.1016/j.jalz.2019.06.4717},
url = {https://doi.org/10.1016/j.jalz.2019.06.4717}
}
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Key findings
- Compared to Whites, Blacks/African Americans and Latinos/Hispanics have 50-100% higher rates of clinical AD, while Asians/Asian Americans have markedly lower rates.
- Participants were required to meet Appropriate Use Criteria for amyloid PET imaging including: etiology of cognitive impairment was unknown, AD was a diagnostic consideration and knowledge of PET results was expected to change diagnosis and management.
- Whites were more likely to have a positive amyloid PET (62.7% [95% CI 62-63%]) versus Blacks/African Americans (53.8% [50-58%]), Latinos/Hispanics (54.1% [51-57%]) and Asian/Asian Americans (45.1% [40-51%]).
- Compared to Whites, all minority groups were more likely to: have been diagnosed with dementia (vs MCI) prior to PET scan; consent by proxy; have Medicare Advantage and have diabetes.
Why it matters
This study compared amyloid PET positivity across racial and ethnic groups and found that Whites were more likely to have a positive amyloid PET than other groups. It addresses differences in a diagnostic test result, not treating, curing, or preventing Alzheimer's disease.
Study details
- Participants18,550
- Effect size62.7%; 53.8%; 54.1%
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 4 / 4 | 18,550 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.1 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 1 / 6 | Cited 0.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Gil D. Rabinovici: h-index 116 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 9 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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