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Social inequalities in multimorbidity, frailty, disability, and transitions to mortality: a 24-year follow-up of the Whitehall II cohort study
Dugravot A, Fayosse A, Dumurgier J, Bouillon K, Rayana TB, Schnitzler A, Kivimaki M, Sabia S et al.. The Lancet. Public health, 2019-12-16
Topic: Risk, prevention and care in population studies
Multimorbidity (hazard ratio [HR] 4·12 [95% CI 3·41-4·98]), frailty (HR 2·38 [95% CI 1·93-2·93]), and disability (HR 1·73 [95% CI 1·34-2·22]) were associated with increased risk of mortality; these associations were not modified by socioeconomic status. In multistate models, occupation was the socioeconomic status indicator that was most strongly associated with inequalities in the transition from healthy state to multimorbidity (HR 1·54 [95% CI 1·37-1·73]), to frailty (HR 2·08 [95% CI 1·85-2·33]), and to disability (HR 1·44 [95% CI 1·18-1·74]).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Dugravot, A., Fayosse, A., Dumurgier, J., Bouillon, K., Rayana, T. B., Schnitzler, A., et al. (2020). Social inequalities in multimorbidity, frailty, disability, and transitions to mortality: a 24-year follow-up of the Whitehall II cohort study. The Lancet. Public health. https://doi.org/10.1016/s2468-2667(19)30226-9
Vancouver
Dugravot A, Fayosse A, Dumurgier J, Bouillon K, Rayana TB, Schnitzler A, et al. Social inequalities in multimorbidity, frailty, disability, and transitions to mortality: a 24-year follow-up of the Whitehall II cohort study. The Lancet. Public health. 2020. doi:10.1016/s2468-2667(19)30226-9. PMID: 31837974.
BibTeX
@article{dugravot2020-31837974,
author = {Dugravot, A. and Fayosse, A. and Dumurgier, J. and Bouillon, K. and Rayana, T. B. and Schnitzler, A. and Kivimaki, M. and Sabia, S. and others},
title = {{Social inequalities in multimorbidity, frailty, disability, and transitions to mortality: a 24-year follow-up of the Whitehall II cohort study}},
journal = {The Lancet. Public health},
year = {2020},
doi = {10.1016/s2468-2667(19)30226-9},
pmid = {31837974},
url = {https://doi.org/10.1016/s2468-2667(19)30226-9}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Multimorbidity (hazard ratio [HR] 4·12 [95% CI 3·41-4·98]), frailty (HR 2·38 [95% CI 1·93-2·93]), and disability (HR 1·73 [95% CI 1·34-2·22]) were associated with increased risk of mortality; these associations were not modified by socioeconomic status.
- In multistate models, occupation was the socioeconomic status indicator that was most strongly associated with inequalities in the transition from healthy state to multimorbidity (HR 1·54 [95% CI 1·37-1·73]), to frailty (HR 2·08 [95% CI 1·85-2·33]), and to disability (HR 1·44 [95% CI 1·18-1·74]).
Why it matters
This 24-year follow-up of the Whitehall II cohort found that multimorbidity, frailty, and disability were associated with increased risk of mortality, and that occupation was the socioeconomic indicator most strongly linked to transitions into these states. It concerns social inequalities in health transitions and mortality and provides no information on treating, curing, or preventing Alzheimer's disease.
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Study details
- Study designcohort study
- Participants308
- Evidence strengthModerate
How this study scored 70/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet. Public health) |
| Journal's citation record | 2 / 4 | The Lancet Public Health: journal h-index 155 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 308 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 326 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 40.8 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 5 / 6 | Cited 23.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 178 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Archana Singh‐Manoux: h-index 124 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 10 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31837974) |
| Free to read | 2 / 2 | Free to read |
| Total | 70 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/s2468-2667(19)30226-9
- PubMed: 31837974
- Original source →
- Free full text: The Lancet Public Health →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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