OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer Disease
LaMontagne PJ, Benzinger TL, Morris JC, Keefe S, Hornbeck R, Xiong C, Grant E, Hassenstab J et al.. medRxiv, 2019-12-15
Topic: Amyloid, tau and blood-test diagnosis
ABSTRACT OASIS-3 is a compilation of MRI and PET imaging and related clinical data for 1098 participants who were collected across several ongoing studies in the Washington University Knight Alzheimer Disease Research Center over the course of 15 years. Participants include 605 cognitively normal adults and 493 individuals at various stages of cognitive decline ranging in age from 42 to 95 years. The OASIS-3 dataset contains over 2000 MR sessions, including multiple structural and functional sequences.
Key findings
- Participants include 605 cognitively normal adults and 493 individuals at various stages of cognitive decline ranging in age from 42 to 95 years.
- The OASIS-3 dataset contains over 2000 MR sessions, including multiple structural and functional sequences.
- PET metabolic and amyloid imaging includes over 1500 raw imaging scans and the accompanying post-processed files from the PET Unified Pipeline (PUP) are also available in OASIS-3.
- OASIS-3 also contains post-processed imaging data such as volumetric segmentations and PET analyses.
Why it matters
OASIS-3 brings together MRI, PET and clinical data on 1,098 people aged 42 to 95 (605 cognitively normal, 493 at various stages of cognitive decline), collected over 15 years across several studies at Washington University's Knight Alzheimer Disease Research Center. It includes more than 2,000 MRI sessions, more than 1,500 amyloid and metabolic PET scans, and ready-processed measurements such as brain-volume segmentations. It is a shared research resource, not a test of any treatment, and on its own it does not show what causes or changes Alzheimer's.
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Study details
- Study designlongitudinal study
- Participants1,098
- Evidence strengthModerate
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 50 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on impact for its field and year, so that was left out: it earned 47 of the 94 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (medRxiv) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,098 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 791 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 87.9 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | 3 / 6 | Cited by 10 other studies in this library |
| Still being cited | 4 / 4 | Cited 411 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Daniel S. Marcus: h-index 45 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 47 / 94 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 47 of the 94 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — Unpaywall lists this copy as free to read: the link above (checked 10 Oct 2026).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
LaMontagne, P. J., Benzinger, T. L., Morris, J. C., Keefe, S., Hornbeck, R., Xiong, C., et al. (2019). OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer Disease. medRxiv. https://doi.org/10.1101/2019.12.13.19014902
Vancouver
LaMontagne PJ, Benzinger TL, Morris JC, Keefe S, Hornbeck R, Xiong C, et al. OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer Disease. medRxiv. 2019. doi:10.1101/2019.12.13.19014902.
BibTeX
@article{lamontagne2019-71309e0e,
author = {LaMontagne, P. J. and Benzinger, T. L. and Morris, J. C. and Keefe, S. and Hornbeck, R. and Xiong, C. and Grant, E. and Hassenstab, J. and others},
title = {{OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer Disease}},
journal = {medRxiv},
year = {2019},
doi = {10.1101/2019.12.13.19014902},
url = {https://doi.org/10.1101/2019.12.13.19014902}
}
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