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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,951–10,975 of 27,380 studies, newest first · page 439 of 1096.

November 2020 25

  1. 2020-11-20

    Kidney Function and Cognitive Decline in Older Adults: Examining the Role of Neurodegeneration

    ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society

    Key finding: Median (IQR) eGFR was 73(60-84) mL/min/1.73 m 2 . +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-11-19

    Targeting Tau to Treat Clinical Features of Huntington's Disease

    ✓ Peer-reviewed Drug development Frontiers in neurology

    Key finding: While motor deficits often confirm diagnosis, cognitive dysfunctions usually manifest early in the disease process and are consistently ranked among the leading factors that impact the patients' quality of life. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-11-18

    Is there a relationship between blood pressure values and dementia?

    ✓ Peer-reviewed Risk factors European heart journal supplements : journal of the European Society of Cardiology

    Key finding: The relationship between arterial hypertension and cognitive decline, two among the conditions with higher prevalence in the elderly population, has gained significant interest, in the scientific community, during the last few years, stemming from the numerous epidemiologic, experimental, and therapeutic evidences suggesting a non-casual correlation between the two conditions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2020-11-17

    Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease

    ✓ Peer-reviewed Disease mechanisms Cell reports. Medicine

    Key finding: A targeted metabolomic analysis of primary and secondary bile acids measured from post-mortem brain samples of 111 individuals supports these results. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-11-17

    The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices

    ✓ Peer-reviewed Prevention trials Brain sciences

    Key finding: This paper concludes that 1. glymphatic clearance plays a major role in Alzheimer's pathology; 2. the vast majority of waste clearance occurs during sleep; 3. dementias are associated with sleep disruption, alongside an age-related decline in AQP4 polarization; and 4. lifestyle choices such as sleep position, alcohol intake, exercise, omega-3 consumption, intermittent fasting and chronic stress all modulate glymphatic clearance.

    Full summary, score breakdown and related studies → Original source

  6. 2020-11-17

    Accelerated MRI-predicted brain ageing and its associations with cardiometabolic and brain disorders

    ✓ Peer-reviewed Long-term cohort studies Scientific reports

    Key finding: We developed a deep neural network model trained on brain MRI scans of healthy people to predict "healthy" brain age. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-11-17

    Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review

    ✓ Peer-reviewed Risk factors PloS one

    Key finding: Identified prognostic factors can help clinicians and policy makers in tailoring management strategies for patients with COVID-19 infectious disease while researchers can utilise our findings to develop multivariable prognostic models that could eventually facilitate decision-making and improve patient important outcomes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2020-11-16

    Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia

    ✓ Peer-reviewed Inflammation and the immune system International journal of molecular sciences

    Key finding: Several experimental studies have shown that noradrenaline modulates neuroinflammation, mainly by acting on microglia/astrocytes function.

    Full summary, score breakdown and related studies → Original source

  9. 2020-11-16

    Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment

    ✓ Peer-reviewed Risk factors Dementia and geriatric cognitive disorders extra

    Key finding: A difference between subjects with and without obesity and memory scores was shown by t tests. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2020-11-16

    A study protocol for a phase II randomised, double-blind, placebo-controlled trial of sodium selenate as a disease-modifying treatment for behavioural variant frontotemporal dementia

    ✓ Peer-reviewed Clinical trials BMJ open

    Key finding: Behavioural variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder often neuropathologically associated with the accumulation of abnormally hyperphosphorylated tau, for which there is currently no disease-modifying treatment. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2020-11-16

    Cerebrospinal Fluid Biomarkers for the Diagnosis and Classification of Alzheimer's Disease Spectrum

    ✓ Peer-reviewed Tau biomarkers Journal of Korean medical science

    Key finding: CSF Aβ42, total tau (t-tau) and phosphorylated tau (p-tau) significantly differed across the three groups. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-11-16

    Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

    ✓ Peer-reviewed Drug development Nature neuroscience

    Key finding: When pathogenic Aβ seeds begin to form, propagate and spread is not known, nor are they biochemically defined. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2020-11-16

    TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

    ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's research & therapy

    Key finding: TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer's disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial activation state. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2020-11-16

    Defining the Lowest Threshold for Amyloid-PET to Predict Future Cognitive Decline and Amyloid Accumulation

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: These optimized thresholds can help to inform future research and clinical trials targeting early Aβ. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2020-11-16

    Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Plasma NfL is superior to plasma t-tau for the diagnosis and prediction of clinical progression of FTLD-S and AD-S. Classification of evidence This study provides Class III evidence that plasma NfL has superior diagnostic and prognostic performance vs plasma t-tau in FTLD and AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2020-11-13

    KALRN: A central regulator of synaptic function and synaptopathies

    ✓ Peer-reviewed Disease mechanisms Gene

    Key finding: These data are correlated to genetic evidence of patient mutations within KALRN and animal models of Kalrn that together give insight into the manner in which this gene may be involved in neurodevelopment and the etiology of disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2020-11-13

    Alcohol consumption and sleep quality: a community-based study

    ✓ Peer-reviewed Risk factors Public health nutrition

    Key finding: We observed a dose-response association between higher alcohol consumption in 2006 and worse sleep quality in 2012 (Ptrend < 0·001), after adjusting for age, sex, socio-economic status, smoking status, physical activity, obesity, plasma lipid profiles, diabetes and hypertension. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2020-11-13

    Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease

    ✓ Peer-reviewed Genetics Cell

    Key finding: Unsupervised analyses indicate that PTMs occur in an ordered manner, leading to Tau aggregation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2020-11-12

    Racial/Ethnic Differences in Health-Related Quality of Life in Persons With and Without Dementia

    ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

    Key finding: Generally, Blacks and Latinos reported higher prevalence of poor HRQOL compared with whites. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2020-11-12

    The Role of ADF/Cofilin in Synaptic Physiology and Alzheimer's Disease

    ✓ Peer-reviewed Disease mechanisms Frontiers in cell and developmental biology

    Key finding: Accumulating evidence indicates that ADF/cofilin also play important roles in neuronal structure and function, including long-term potentiation and depression. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2020-11-12

    Which moral barriers and facilitators do physicians encounter in advance care planning conversations about the end of life of persons with dementia? A meta-review of systematic reviews and primary studies

    ✓ Peer-reviewed End-of-life care BMJ open

    Key finding: Importance and objective Conducting advance care planning (ACP) conversations with people with dementia and their relatives contributes to providing care according to their preferences.

    Full summary, score breakdown and related studies → Original source

  22. 2020-11-12

    Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development

    ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Genome-wide association studies have led to numerous genetic loci associated with Alzheimer's disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2020-11-12

    Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults

    ✓ Peer-reviewed Mild cognitive impairment The lancet. Healthy longevity

    Key finding: We used Cox proportional hazards models and logistic regressions to assess whether circadian disturbances predict an increased risk of incident Alzheimer's dementia and conversion of mild cognitive impairment to Alzheimer's dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-11-11

    Sixty-Day Outcomes Among Patients Hospitalized With COVID-19

    ✓ Peer-reviewed Risk factors Annals of Internal Medicine

    Key finding: Of 1648 patients with COVID-19 admitted to 38 hospitals, 398 (24.2%) died during hospitalization and 1250 (75.8%) survived. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2020-11-11

    Fluid Candidate Biomarkers for Alzheimer's Disease: A Precision Medicine Approach

    ✓ Peer-reviewed Biomarkers Journal of personalized medicine

    Key finding: The clinical role of plasma Aβ peptides should be better elucidated with further studies that also compare the accuracy of the different ultrasensitive techniques. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →