Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,326–12,350 of 27,380 studies, newest first · page 494 of 1096.
November 2019 25
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2019-11-06
White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study
68/100 ✓ Peer-reviewed Biomarkers NeuroImage. Clinical
Key finding: Presence on T2-weighted images of white matter hyperintensities (WMH) has been previously shown to be more commonly associated with GRN mutations rather than other forms of FTD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-11-06
GIP has neuroprotective effects in Alzheimer and Parkinson's disease models
38/100 ✓ Peer-reviewed Drug development Peptides
Key finding: Recently, novel dual GLP-1/GIP receptor agonists have been developed. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-11-06
Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease
57/100 ✓ Peer-reviewed Genetics Acta neuropathologica communications
Key finding: Proteomic profiling of patient fluids may help identify novel therapeutic targets and biomarkers associated with AD pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-11-06
Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies
74/100 ✓ Peer-reviewed Prevention and risk The Lancet. Neurology
Key finding: Over a long period of observation, no evidence was found that a specific AHM drug class was more effective than others in lowering risk of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-11-05
Mid-life and late-life vascular risk factor burden and neuropathology in old age
39/100 ✓ Peer-reviewed Vascular contributions Annals of clinical and translational neurology
Key finding: The median time interval between FSRP and death was 33.4 years for mid-life FSRP and 4.4 years for final FSRP measurement before death. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-11-05
Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge
42/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in aging neuroscience
Key finding: Studies considering both age and sex remain limited, despite sex dimorphism of astrocytes and microglial cells is largely recognized. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-11-05
Lysosomal Dysfunction at the Centre of Parkinson's Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis
47/100 ✓ Peer-reviewed Caregiving Trends in neurosciences
Key finding: Parkinson's disease (PD) and frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS) are insidious and incurable neurodegenerative diseases that represent a significant burden to affected individuals, caregivers, and an ageing population.
Full summary, score breakdown and related studies → Original source
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2019-11-04
Bias-adjustment in neuroimaging-based brain age frameworks: A robust scheme
41/100 ✓ Peer-reviewed Digital health tools NeuroImage. Clinical
Key finding: The level of prediction error in the brain age estimation frameworks is associated with the authenticity of statistical inference on the basis of regression models. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-11-04
From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
45/100 ✓ Peer-reviewed Drug development Acta neuropathologica
Key finding: It has been shown that tau may be secreted in the interstitial fluid in an active manner as reflected by high and constant concentration of extracellular tau during Alzheimer's pathology. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-11-04
Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report
52/100 ✓ Peer-reviewed Genetics Nature medicine
Key finding: Our findings have implications for the role of APOE in the pathogenesis, treatment and prevention of Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2019-11-04
Effect of nutrition on neurodegenerative diseases. A systematic review
58/100 ✓ Peer-reviewed Prevention and risk Nutritional neuroscience
Key finding: The data showed that malnutrition and low body mass index (BMI) is correlated with the higher development of dementia and mortality. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-11-03
Aloe-emodin: A review of its pharmacology, toxicity, and pharmacokinetics
38/100 ✓ Peer-reviewed Disease mechanisms Phytotherapy research : PTR
Key finding: Emerging evidence suggests that aloe-emodin exhibits many pharmacological effects, including anticancer, antivirus, anti-inflammatory, antibacterial, antiparasitic, neuroprotective, and hepatoprotective activities. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-11-03
Factors Affecting Caregivers' Acceptance of the Use of Wearable Devices by Patients With Dementia: An Extension of the Unified Theory of Acceptance and Use of Technology Model
42/100 ✓ Peer-reviewed Digital health tools American journal of Alzheimer's disease and other dementias
Key finding: The results of the extended model show that social influence, effort expectancy, facilitating conditions, and behavioral intention (BI) all had P P value for RC and TA was greater than .05, hence were insignificant.
Full summary, score breakdown and related studies → Original source
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2019-11-02
Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application
38/100 ✓ Peer-reviewed Disease mechanisms Journal of controlled release : official journal of the Controlled Release Society
Key finding: As well, curcumin can be metabolized rapidly by intestinal tract which can also result in low oral bioavailability.
Full summary, score breakdown and related studies → Original source
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2019-11-01
Association between air pollution and risk of vascular dementia: A multipollutant analysis in Taiwan
63/100 ✓ Peer-reviewed Risk factors Environment international
Key finding: After potential confounders and other air pollutants were controlled for, high concentrations of coarse particulate matter (10 µm or less in diameter) and carbon monoxide (CO) were sporadically associated with higher OR of VaD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-11 month only
A contemporary review of obstructive sleep apnea
39/100 ✓ Peer-reviewed Risk factors Current opinion in pulmonary medicine
Key finding: Decreased sleep time in the elderly is a precipitating factor in amyloid retention. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-11 month only
Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial
75/100 ✓ Peer-reviewed Drug development The British journal of psychiatry : the journal of mental science
Key finding: Participants in the placebo group displayed cognitive and functional decline, whereas lithium-treated patients remained stable over 2 years. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-11 month only
Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders
55/100 ✓ Peer-reviewed Genetics Annals of translational medicine
Key finding: Two novel SNPs (rs465401 and rs460420), both near the ADAMTS1 gene on chromosome 21, showed genome-wide significant associations with CSF NFL. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-11 month only
Computerized cognitive performance assessments in the Brooklyn Cognitive Impairments in Health Disparities Pilot Study
50/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Cognigram was piloted in the Emergency Department, Family Medicine, and Geriatric Psychiatry clinics: 58 adults (23 men, 35 women), 67.9 ± 9.8 years (range 43-91), completed the Cognigram and 5-item liking survey. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-11-01
MicroRNAs as biomarkers of diabetic retinopathy and disease progression
41/100 ✓ Peer-reviewed Risk factors Neural regeneration research
Key finding: In addition, certain microRNAs in vitreous humor were dysregulated in proliferative diabetic retinopathy compared to controls.
Full summary, score breakdown and related studies → Original source
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2019-11-01
Antidiabetic medication and risk of dementia in patients with type 2 diabetes: a nested case-control study
60/100 ✓ Peer-reviewed Drug development European journal of endocrinology
Key finding: Use of metformin, DPP4 inhibitors, GLP1 analogs and SGLT2 inhibitors was associated with lower risk of dementia in patients with diabetes. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-11-01
Towards clinical utility of polygenic risk scores
38/100 ✓ Peer-reviewed Genetics Human molecular genetics
Key finding: In conclusion, it is becoming clear that PRS have value in disease risk prediction and there are multiple areas where this may have clinical utility.
Full summary, score breakdown and related studies → Original source
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2019-11-01
Plant-Based Dietary Patterns, Plant Foods, and Age-Related Cognitive Decline
45/100 ✓ Peer-reviewed Prevention trials Advances in nutrition (Bethesda, Md.)
Key finding: We also identify knowledge gaps and recommend future studies to identify whether plant-exclusive diets have an added cognitive advantage compared with plant-centered diets with fish and/or small amounts of animal foods.
Full summary, score breakdown and related studies → Original source
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2019-11-01
Stalling life expectancy and increased mortality in working ages deserve urgent attention
36/100 ✓ Peer-reviewed Risk factors The Lancet Public Health
Key finding: The effect of austerity and associated budgets are strong contenders,3Ruckert A Labonté R Health inequities in the age of austerity: the need for social protection policies. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-11-01
Association between fast-food outlet exposure and Body Mass Index in 124,286 Lifelines participants
39/100 ✓ Peer-reviewed Risk factors European Journal of Public Health
Key finding: Fast-food outlet exposure may be an important environmental determinant of BMI. +3 more findings
Full summary, score breakdown and related studies → Original source
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