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The Spatial-Temporal Ordering of Amyloid Pathology and Opportunities for PET Imaging
Fantoni E, Collij L, Lopes Alves I, Buckley C, Farrar G, AMYPAD consortium.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019-12-13
Topic: Amyloid, tau and blood-test diagnosis
Although clinical routine focuses on dichotomous and visual interpretation of amyloid PET, regional image assessment in research settings may yield additional opportunities. Understanding the regional-temporal evolution of amyloid pathology may enable earlier identification of subjects in the Alzheimer Disease pathologic continuum, as well as a finer-grained assessment of pathology beyond traditional dichotomous measures. This review summarizes current research in the detection of regional amyloid deposition patterns and its potential for staging amyloid pathology. Pathology studies, cross-sectional and longitudinal PET-only studies, and comparative PET and autopsy studies are included. Despite certain differences, cortical deposition generally precedes striatal pathology, and in PET-only studies, medial cortical regions are seen to accumulate amyloid earlier than lateral regions. Based on regional amyloid PET, multiple studies have developed and implemented models for staging amyloid pathology that could improve subject selection into secondary prevention trials and visual assessment in clinical routine.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Fantoni, E., Collij, L., Lopes Alves, I., Buckley, C., Farrar, G., & AMYPAD consortium. (2020). The Spatial-Temporal Ordering of Amyloid Pathology and Opportunities for PET Imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.119.235879
Vancouver
Fantoni E, Collij L, Lopes Alves I, Buckley C, Farrar G, AMYPAD consortium. The Spatial-Temporal Ordering of Amyloid Pathology and Opportunities for PET Imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2020. doi:10.2967/jnumed.119.235879. PMID: 31836683.
BibTeX
@article{fantoni2020-31836683,
author = {Fantoni, E. and Collij, L. and Lopes Alves, I. and Buckley, C. and Farrar, G. and {AMYPAD consortium}},
title = {{The Spatial-Temporal Ordering of Amyloid Pathology and Opportunities for PET Imaging}},
journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
year = {2020},
doi = {10.2967/jnumed.119.235879},
pmid = {31836683},
url = {https://doi.org/10.2967/jnumed.119.235879}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Understanding the regional-temporal evolution of amyloid pathology may enable earlier identification of subjects in the Alzheimer Disease pathologic continuum, as well as a finer-grained assessment of pathology beyond traditional dichotomous measures.
- This review summarizes current research in the detection of regional amyloid deposition patterns and its potential for staging amyloid pathology.
- Pathology studies, cross-sectional and longitudinal PET-only studies, and comparative PET and autopsy studies are included.
- Despite certain differences, cortical deposition generally precedes striatal pathology, and in PET-only studies, medial cortical regions are seen to accumulate amyloid earlier than lateral regions.
- Based on regional amyloid PET, multiple studies have developed and implemented models for staging amyloid pathology that could improve subject selection into secondary prevention trials and visual assessment in clinical routine.
Why it matters
This review summarizes research on regional patterns of amyloid deposition and models for staging amyloid pathology using PET. It discusses earlier identification and staging for research and trials, not a treatment, cure or prevention of Alzheimer's disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Study designcross-sectional
- Evidence strengthModerate
How this study scored 47/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine) |
| Journal's citation record | 2 / 4 | Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 62 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.8 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 5.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 2 / 4 | Cited 22 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Gill Farrar: h-index 30 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Vrije Universiteit Amsterdam: institution h-index 1,014 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31836683) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.2967/jnumed.119.235879
- PubMed: 31836683
- Original source →
- Free full text: jnm.snmjournals.org →
Full text: free to read — Unpaywall lists this copy as free to read: the link above (checked 10 Oct 2026).
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